A5039672854- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Infant Health and Development
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Fractal and DNA sequence analysis
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Hemophilia Treatment and Research
- Neural Networks and Applications
- Blood Coagulation and Thrombosis Mechanisms
- Evolutionary Psychology and Human Behavior
- Olfactory and Sensory Function Studies
- Neonatal Respiratory Health Research
- Protease and Inhibitor Mechanisms
- Receptor Mechanisms and Signaling
Icahn School of Medicine at Mount Sinai
2008-2025
Albany Medical Center Hospital
2021-2023
Allen Institute for Brain Science
2017-2021
Child Health and Development Institute
2021
Scripps Research Institute
2006
Maternal care, including by non-biological parents, is important for offspring survival1-8. Oxytocin1,2,9-15, which released the hypothalamic paraventricular nucleus (PVN), a critical maternal hormone. In mice, oxytocin enables neuroplasticity in auditory cortex recognition of pup distress15. However, it unclear how initial parental experience promotes signalling and cortical plasticity reliable care. Here we continuously monitored behaviour female virgin mice co-housed with an experienced...
Animals respond to changing contingencies maximize reward. The orbitofrontal cortex (OFC) is important for flexible responding when established change, but the underlying cognitive mechanisms are debated. We tested rats with sham or OFC lesions in radial maze tasks that varied frequency of contingency changes and measured both perseverative non-perseverative errors. When were changed rarely, learned quickly performed better than lesions. Rats made fewer errors, rarely entering non-rewarded...
Memory can inform goal-directed behavior by linking current opportunities to past outcomes. The orbitofrontal cortex (OFC) may guide value-based responses integrating the history of stimulus–reward associations into expected outcomes, representations predicted hedonic value and quality. Alternatively, OFC rapidly compute flexible “online” reward predictions associating stimuli with latest outcome. neurons develop predictive codes when rats learn associate arbitrary but extent which coding...
ABSTRACT Newborns of many mammalian species are partial poikilotherms and require adult thermoregulatory care for survival. In mice, pup survival in cold cool ambient temperature depends on the ability caregivers to huddle pups bring them into a high-quality nest. It is therefore essential that mice adjust parental as function changes temperature. Here, we investigated how mouse maternal adapts range temperatures, from warm. We show affect several individual co-parenting behaviors both dams...
Abstract Maternal care is profoundly important for mammalian survival, and non-biological parents can express it after experience with infants. One critical molecular signal maternal behavior oxytocin, a hormone centrally released by hypothalamic paraventricular nucleus (PVN). Oxytocin enables plasticity within the auditory cortex, necessary step responding to infant vocalizations. To determine how this change occurs during natural experience, we continuously monitored homecage of female...
Adapting flexibly to changing circumstances is guided by memory of past choices, their outcomes in similar circumstances, and a method for choosing among potential actions. The hippocampus (HPC) needed remember episodes, the prefrontal cortex (PFC) helps guide retrieval. Single-unit activity HPC PFC correlates with such cognitive functions. Previous work recorded CA1 mPFC as male rats performed spatial reversal task plus maze that requires both structures, found reactivate representations...
<h2>Summary</h2> Episodic memory requires the hippocampus and prefrontal cortex to guide decisions by representing events in spatial, temporal, personal contexts. Both brain regions have been described cognitive theories that represent context as locations maps or spaces. We query whether ensemble spiking these spatial structures rats performed tasks. From each ensemble, we construct a state-space with point defined coordinated of single pairs units 125-ms bins investigate how discriminate...
Populations of hippocampal and cortical neurons respond reliably to important behavioral variables. In any task, only a few single cells each population indicating region exhibits sparse coding. This coding constrains the set possible sequential inter-spike interval (ISI) patterns can form, suggesting that CA1 mPFC neural activity may be organized into repeated, persistent temporal signals. We simultaneously recorded unit in medial prefrontal cortex (mPFC) ensembles as rats performed spatial...
Abstract Memory helps us adapt to changing circumstances but needs guidance retrieve relevant episodes. Episodic memory requires the hippocampus, prefrontal cortex (PFC) guides retrieval, how their representations interact is unclear. Using state-space analysis of neuronal spiking, we found CA1 and PFC activity within between rats formed similar, low-dimensional, region-specific “shapes” representing different tasks tested in same maze. Task shapes were organized by behaviorally salient...
Memory helps us adapt to changing circumstances but needs guidance retrieve relevant episodes. Episodic memory requires the hippocampus, prefrontal cortex (PFC) guides retrieval, how their representations interact is unclear. We found CA1 and PFC activity within between rats formed similar, low-dimensional, region-specific “shapes” representing different tasks tested in same maze. Task shapes were organized by behaviorally salient variables including time maze location. predicted when both...
To adapt to changing circumstances, we often recall similar situations and the consequences of past choices. Memory for recent events requires hippocampus (HPC); using memory a new circumstance can require orbitofrontal cortex (OFC). Spatial learning is impaired by HPC but not OFC dysfunction. Rather, an unfamiliar reversal well-established contingency dysfunction, suggesting that spatial path reward both structures their interactions. investigate possible interactions, simultaneously...