A5111540099- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Viral-associated cancers and disorders
- HIV/AIDS Impact and Responses
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Pharmaceutical studies and practices
- Lymphoma Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Pharmaceutical Practices and Patient Outcomes
- Cervical Cancer and HPV Research
- Innovations in Medical Education
- Parvovirus B19 Infection Studies
- Pharmacological Effects and Toxicity Studies
- Pneumonia and Respiratory Infections
- Cytomegalovirus and herpesvirus research
- Global Health Workforce Issues
- Chronic Lymphocytic Leukemia Research
Jos University Teaching Hospital
2016-2025
University of Jos
2015-2024
Spectrum Health
2019-2023
Corewell Health Blodgett Hospital
2019-2023
AIDS Prevention Initiative in Nigeria
2009-2021
University College Hospital, Ibadan
2014
University of Ibadan
2014
Kenya Medical Research Institute
2013
Ahmadu Bello University
2013
National Veterinary Research Institute
2013
Background Individuals living with HIV/AIDS in sub-Saharan Africa generally take more than 90% of prescribed doses antiretroviral therapy (ART). This number exceeds the levels adherence observed North America and dispels early scale-up concerns that would be inadequate settings extreme poverty. paper offers an explanation theoretical model ART success based on results ethnographic study three African countries. Methods Findings Determinants for HIV-infected persons were examined research...
Background The rollout of antiretroviral therapy in sub-Saharan Africa has brought lifesaving treatment to millions HIV-infected individuals. Treatment is lifelong, however, and continue benefit, patients must remain care. Despite this, systematic investigations retention have repeatedly documented high rates loss follow-up from HIV programs. This paper introduces an explanation for missed clinic visits subsequent disengagement among enrolled care programs Africa. Methods Findings...
Viral load (VL) quantification is considered essential for determining antiretroviral treatment (ART) success in resource-rich countries. However, it not widely available resource-limited settings where the burden of human immunodeficiency virus infection greatest. In absence VL monitoring, switches to second-line ART are based on World Health Organization (WHO) clinical or immunologic failure criteria.We assessed performance CD4 cell criteria predict virologic outcomes a large program...
First identified in 1947 Uganda, Zika virus (ZIKV) has remained largely unstudied until the recent outbreak Latin America. This study aimed to measure prevalence of ZIKV febrile patients Senegal and Nigeria samples collected from 1992 2016. The seroprevalence was 6.2% based on immunoglobulin M negative for dengue reactivity. envelope amplified 4 samples. Phylogenetic analysis showed that ZIKVs belonged African lineage, grouping with either Nigerian or MR766 sublineages. provides evidence...
To determine the efficacy of patient-selected treatment partners on virologic and adherence outcomes during first-line antiretroviral therapy.Randomized controlled trial. SETTING AND ANALYTICAL APPROACH: Between June 2006 December 2007, 499 HIV-infected adults in Jos, Nigeria, were randomized to standard care (SOC) or partner-assisted therapy (TPA). Each patient was followed for 48 weeks. Virologic outcomes, drug pick-up, CD4 cell counts, mortality are reported.At week 24, undetectable viral...
Background Adverse Drug Reactions (ADRs) are a major clinical and public health problem world-wide. The prompt reporting of suspected ADRs to regulatory authorities activate drug safety surveillance regulation appears be the most pragmatic measure for addressing problem. This paper evaluated pharmacovigilance (PV) training model that was designed improve in programs treating Human Immunodeficiency Virus (HIV), Tuberculosis (TB) Malaria. Methods A Structured Pharmacovigilance Training...
Adverse drug reactions (ADRs) associated with antiretroviral therapy (ART) can rapidly reverse the gains of ART resulting in poor health outcomes. We need an improved understanding specific ART-related ADRs that influence virologic outcomes.To investigate frequency clinical and assess their effect on failure patients ART.We described prevalence major ADRs, association between a clinic cohort HIV-1 infected Nigerians aged ≥18 years, firstline June 2004 February 2012. Multivariable logistic...
Introduction Adherence to antiretroviral therapy (ART) and retention in treatment programs are required for successful virologic suppression outcomes. As the number of adolescents living with HIV continues increase globally, more information about adherence patterns during through transition from child- adult-centered care is needed ensure provision a high level inform development targeted interventions improve patient outcomes this vulnerable population. In analysis, we sought describe...
Youth living with HIV (YLH) are disproportionately impacted by poor outcomes along the entire care continuum. In a 2020–2022 pilot study, iCARE Nigeria, successfully tested combination intervention incorporating mobile health technology and peer navigation to: 1) improve testing linkage to for young men, especially men who have sex (YMSM) 2) medication adherence treatment YLH. The was scaled up 5 sites in 3 Nigerian cities. Implementation research used understand site perspectives on...
Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a chief cause of death in sub-Saharan Africa. In this study, the clinical characteristics and predictors mortality among hospitalized HIV infected adult Nigerians are reported.The records 354 patients were reviewed for demographic characteristics. Predictors using logistic regression retrospective study also reviewed.A total 109 (30.8%) males 245 (69.2%) females participated study. The mean age all participants...
We describe the prevalence and risk factors for advanced liver fibrosis (≥9.3 kPa) using transient elastography in human immunodeficiency virus (HIV)-monoinfected HIV/HBV (hepatitis B virus)-coinfected, antiretroviral naive adults Nigeria.HBV coinfection HBV DNA levels significantly increased of HIV patients, respectively.
ABSTRACT Tuberculosis (TB) is the most common opportunistic infection in human immunodeficiency virus (HIV)-infected patients and emergence of drug-resistant tuberculosis (DR-TB) a growing problem resource-limited settings. Adequate infrastructure for testing drug sensitivity sufficient evidence first-line resistance are currently unavailable Nigeria. We collected sputum samples from HIV-infected enrolled Harvard PEPFAR/APIN Plus program over 12 months at two PEPFAR antiretroviral therapy...
Background. Decentralization of care and treatment for HIV infection in Africa makes services available local health facilities. has been associated with improved retention comparable or superior outcomes, but patient experiences are not well understood. Methods. We conducted a qualitative study decentralized Plateau State, north central Nigeria. Five sites the State Initiative were purposefully selected. Ninety-three patients 16 providers at these participated individual interviews focus...
Xpert MTB/Rif (Xpert) is described as a game changer in tuberculosis (TB) control. We evaluated the impact of on diagnosis, time to treatment, and treatment outcome among patients with HIV associated TB Nigeria. Adults being for pulmonary (PTB) were consecutively enrolled into study cohort. At baseline, expectorated sputa examined using smear microscopy Mycobacterium (MTB) acid fast bacilli, respectively. Patients diagnosed followed-up until 6 months post diagnosis. was defined sputum...
Nigeria adopted dolutegravir (DTG) as part of first line (1L) antiretroviral therapy (ART) in 2017. However, there is limited documented experience using DTG sub-Saharan Africa. Our study assessed acceptability from the patient’s perspective well treatment outcomes at 3 high-volume facilities Nigeria. This a mixed method prospective cohort with 12 months follow-up between July 2017 and January 2019. Patients who had intolerance or contraindications to non-nucleoside reverse-transcriptase...
Research productivity in Sub-Saharan Africa has the potential to affect teaching, student quality, faculty career development, and translational country-relevant research as it developed countries. Nigeria is most populous country Africa, with an academic infrastructure that includes 129 universities 45 medical schools; however, despite size, unacceptably poor health status indicators. To further develop Nigeria, development topics were identified within six Nigerian of nine institutions...
Objective: Since 2010, Nigeria has adopted World Health Organization (WHO) ‘Option B’ which requires administration of triple antiretroviral prophylaxis or treatment (ART) to all HIVinfected pregnant women. We studied the transmission outcomes HIV-exposed children up 18 months age. Design: This was a retrospective, observational study HIV-infected women and their exposed infants who accessed prevention mother child (PMTCT) services at Jos University Teaching Hospital, Jos, North-central...
Adverse drug reactions associated with efavirenz (EFV) therapy are poorly described beyond the first year of treatment. We aimed to describe incidence and predictors EFV-related adverse (ADRs) in a cohort adult Nigerian HIV-infected patients on antiretroviral (ART).This retrospective study utilized clinical data HIV-1 infected adults (aged ≥15 years), commenced containing-regimen between January 2004 December 2011. The time-dependent occurrence events as defined by World Health Organization...
Differentiated care refers collectively to flexible service models designed meet the differing needs of HIV-infected persons in resource-scarce settings. Decentralization is one such model. Retention a key indicator for monitoring success HIV treatment and programs. We used multiple measures compare retention cohort patients receiving at "hub" (central) "spoke" (decentralized) sites large public program north central Nigeria.This retrospective study utilized longitudinal data representing...
This study examines the use of various direct observation therapy-HAART treatment support modalities in Jos, Nigeria. A 12-month observational enrolling 175 antiretroviral naïve patients into four arms (highly active therapy); daily observed therapy (DOT), twice weekly (TWOT), (WOT) and self-administered (SAT), examined community using family members. Treatment outcomes were much better treatment-supported groups compared with control self-therapy group. CD4 cell increases 218/microL...
The World Health Organization (WHO) recommends periodic surveillance of transmitted drug resistance (TDR) in communities which antiretroviral therapy (ART) has been scaled-up for greater than 3 years. We conducted a survey TDR mutations among newly detected HIV-infected (ARV)-naive pregnant women. From May 2010 to March 2012, 38 ARV-naive women were recruited three hospitals Jos, Plateau state, north central Nigeria. Eligible subjects using modified version the binomial sequential sampling...
Our objective was to determine tuberculosis (TB) incidence and evaluate TB risk in adults after one or more years of use combination antiretroviral therapy (cART) through a retrospective cohort study Jos, Nigeria. We studied HIV-infected treated with ART for at least 1 year. Based on immunologic virologic responses ART, patients were categorized into four groups: CD4 T cell count ≥350 cells/mm3 HIV-1 RNA level ≤400 copies/ml (group 1), >400 2), <350 3), 4). Time incident the groups analyzed...
For patients on antiretroviral therapy (ART), treatment interruptions can impact patient outcomes and result in the accumulation of drug resistance mutations leading to virologic failure. There are minimal published data an ART stock shortage development (DRMs). In this report, we evaluate from enrolled Government Nigeria National Program that were receiving at time a national late 2003. We conducted cross-sectional evaluation samples collected between December 2004 August 2005 failure...
Objectives: The study sought to determine the prevalence and risk factors associated with Hepatitis B surface antigenemia (HBsAg) positivity among pregnant women in Jos, Nigeria. Methodology: This was a cross-sectional carried out population five healthcare facilities between November 1, 2017 April 30, 2018. Informed consent obtained, data on sociodemographic for hepatitis virus (HBV) infection were collected. viral assessed using vitro HBsAg diagnostic rapid kit (Acon Laboratories, USA)....