A5036694123- Vector-borne infectious diseases
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Insect Resistance and Genetics
- Insect and Pesticide Research
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Viral Infections and Vectors
- Helminth infection and control
- Vector-Borne Animal Diseases
- Parasitic Infections and Diagnostics
- Insect Pest Control Strategies
- Insect symbiosis and bacterial influences
- Antimicrobial Peptides and Activities
- Coccidia and coccidiosis research
- Heat shock proteins research
- Redox biology and oxidative stress
- Malaria Research and Control
- Parasitic Diseases Research and Treatment
- Viral gastroenteritis research and epidemiology
- Parasitic infections in humans and animals
- Glutathione Transferases and Polymorphisms
- Toxin Mechanisms and Immunotoxins
- Insect and Arachnid Ecology and Behavior
- Dengue and Mosquito Control Research
Kitasato University
2016-2025
National Institute of Animal Health
2008-2024
National Agriculture and Food Research Organization
2007-2024
Bangladesh Agricultural University
2015
The University of Tokyo
2009-2014
Agricultural Research Organization
2004-2010
Ministry of Agriculture, Forestry and Fisheries
2001-2007
Kagoshima University
2007
Obihiro University of Agriculture and Veterinary Medicine
2007
Jiangsu Institute of Parasitic Diseases
2005
Acaricide failure has been on the rise in western and central cattle corridor of Uganda. In this study, we identified tick species associated with acaricide determined their susceptibility to various molecules used for control Uganda.In cross sectional samples were collected level from 54 purposively selected farms (from 17 districts) that mostly had a history failure. Larval packet test was screen 31 populations 30 at discriminating dose (DD) 2 × DD five panels commercial belonging...
ABSTRACT Antimicrobial peptides are major components of host innate immunity, a well-conserved, evolutionarily ancient defensive mechanism. Infectious disease-bearing vector ticks thought to possess specific defense molecules against the transmitted pathogens that have been acquired during their evolution. We found in tick Haemaphysalis longicornis novel parasiticidal peptide named longicin may evolved from common ancestral resembling spider and scorpion toxins. H. is primary for Babesia sp....
Vector ticks possess a unique system that enables them to digest large amounts of host blood and transmit various animal human pathogens, suggesting the existence evolutionally acquired proteolytic mechanisms. We report here molecular reverse genetic characterization multifunctional cysteine protease, longipain, from babesial parasite vector tick Haemaphysalis longicornis. Longipain shares structural similarity with papain-family proteases obtained invertebrates vertebrates. Endogenous...
Haemaphysalis longicornis is a tick of importance to health, as it serves vector several pathogens, including Theileria orientalis, Babesia ovata, Rickettsia japonica and the severe fever with thrombocytopenia syndrome virus (SFTSV). Presently, major method control for this use chemical acaricides. The glutathione S-transferase (GST) system one mechanism through which metabolizes these Two GSTs from H. (HlGST HlGST2) have been previously identified. Enzyme kinetic studies were performed...
Ticks are obligate hematophagous parasites that have successfully developed counteractive means against their hosts' immune and hemostatic mechanisms, but ability to cope with potentially toxic molecules in the blood remains unclear. Iron is important various physiological processes can be living cells when excess. We previously reported hard tick Haemaphysalis longicornis has an intracellular (HlFER1) a secretory (HlFER2) ferritin, both crucial successful feeding reproduction. Ferritin gene...
Previous studies indicated that inorganic pyrophosphatase of Ascaris suum (AsPPase) plays an important role in larval survival the host. Here we describe a precise for AsPPase molting and development also potential recombinant (rAsPPase) protective immunity to A. infection. Using reverse transcriptase PCR analysis, found disruption gene function by RNA interference resulted suppression mRNA levels. caused inhibition third-stage larvae (31%) native protein expression, as demonstrated 56%...
Malaria transmission-blocking vaccines based on antigens expressed in sexual stages of the parasites are considered one promising strategy for malaria control. To investigate feasibility developing noninvasive mucosal against Plasmodium falciparum, intranasal immunization experiments with Pichia pastoris-expressed recombinant Pfs25 proteins were conducted. Mice intranasally immunized presence a potent adjuvant cholera toxin induced robust systemic as well antibodies. All mouse immunoglobulin...
Tick control is an essential aspect of controlling the spread tick-borne diseases affecting humans and animals, but it presently faces several challenges. Development anti-tick vaccine aimed at designing cost-effective environmentally friendly protection against ticks as alternative to use chemical acaricides. A single from tick midgut protein Bm86 currently available for field applications, its efficacy limited only some species. Identification candidate antigens that can affect multiple...
Ticks are notorious hematophagous ectoparasites and vectors of many deadly pathogens. As an effective vector, ticks must break the strong barrier provided by skin their host during feeding, saliva contains a complex mixture bioactive molecules that paralyze defenses. The receptor for advanced glycation end products (RAGE) mediates immune cell activation at inflammatory sites is constitutively highly expressed in skin. Here, we demonstrate longistatin secreted with tick Haemaphysalis...
Ticks are obligate hematophagous parasites important economically and to health. consume large amounts of blood for their survival reproduction; however, iron in could lead oxidative stress. use several molecules such as glutathione S-transferases (GSTs), ferritins, peroxiredoxins cope with This study aimed identify characterize the GSTs hard tick Haemaphysalis longicornis order determine if they have a role coping Genes encoding H. were isolated from midgut CDNA library. been cloned...
Ticks feed exclusively on blood to obtain their nutrients, but the gene products that mediate digestion processes in ticks remain unknown. We report molecular characterization and possible function of a serine carboxypeptidase (HlSCP1) identified midgut hard tick Haemaphysalis longicornis . HlSCP1 consists 473 amino acids with peptidase S10 family domain shows structural similarity carboxypeptidases reported from other arthropods, yeasts, plants mammals. Endogenous is strongly expressed...
Fish-borne liver and intestinal flukes are helminth pathogens that have a negative impact on public health worldwide. We herein investigated the status of infection by metacercariae (MC) fish-borne trematodes (FBTs) in randomly selected freshwater wild fishes. Five species fishes were collected digested artificially using digestion fluid to recover MC. All fish species, namely, ticto barb (Puntius ticto) (14/16, 87.5%), banded gourami (Colisa fasciata) (8/12, 66.7%), garfish (Xenentodon...