A5048053783- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Muscle and Compartmental Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Hemophilia Treatment and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- SARS-CoV-2 and COVID-19 Research
Maastricht University Medical Centre
2022-2025
Maastricht University
2021-2025
Background: Coronavirus Disease 2019 (COVID-19) patients often present with thromboembolic events. In COVID-19 patients, routine hemostatic assays cannot correctly identify at risk for Viscoelastic testing rotational thromboelastometry (ROTEM) might improve the characterization of COVID-19-associated coagulopathy. Objective: To unravel underlying coagulopathy and fibrinolysis over time as measured by serial assessment heparin-independent (FIBTEM EXTEM) illustrating (tissue plasminogen...
IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection is associated with a clear prothrombotic phenotype. Although the exact pathophysiological mechanisms are not yet fully understood, thrombosis clearly highly important in prognosis and outcome of COVID-19. As such, there need for diagnostic analysis quantification coagulation potential these patients, both at diagnosis follow-up. Global assays like thrombin generation (TG) rotational thromboelastometry (ROTEM)...
Thrombotic complications are common in Coronavirus disease 2019 (COVID-19) patients, with pulmonary embolism (PE) being the most frequent. Randomised trials have provided inconclusive results on optimal dosage of thromboprophylaxis critically ill COVID-19 patients. We utilized data from multicentre CAPACITY-COVID patient registry to assess effect differential application Low Molecular Weight Heparin (LMWH) dose protocols PE and in-hospital mortality risk An instrumental variable analysis was...
COVID-19 associated coagulopathy (CAC) is with an increase in thromboembolic events. Current guidelines recommend prophylactic heparins the management of CAC. However, efficacy this strategy intensive care population remains uncertain. We aimed to measure thrombin generation (TG) assess CAC unit (ICU) patients receiving thromboprophylaxis low molecular weight heparin (LMWH) or unfractionated (UFH). In addition, we performed statistical modeling link TG parameters patient characteristics and...
Background Hemophilia A (HA) is characterized by decreased or absent factor VIII (FVIII) activity. Current FVIII assays are based on clotting time and thus only provide information about the initiation of coagulation. In contrast, thrombin generation (TGAs) can be used to measure full coagulation spectrum initiation, propagation, termination that whole course inhibition. However, commercially available TG kits lack sensitivity for measurements hemophilia plasma within lower ranges, which...