A5100764542- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Dental Health and Care Utilization
- Angiogenesis and VEGF in Cancer
- Hepatitis B Virus Studies
- Iron Metabolism and Disorders
- Lymphoma Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Oral health in cancer treatment
- Oral microbiology and periodontitis research
- Ferroptosis and cancer prognosis
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Brain Metastases and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Cancer Mechanisms and Therapy
- Parasitic infections in humans and animals
Korea University
2015-2025
Korea University Medical Center
2010-2024
CHA Bundang Medical Center
2024
CHA University
2024
Ewha Womans University
2024
Ansan University
2023
Weatherford College
2019
Sungkyunkwan University
2016
Samsung Medical Center
2016
Sejong General Hospital
2009
<h3>Importance</h3> Diagnostic low-dose ionizing radiation has great medical benefits; however, its increasing use raised concerns about possible cancer risks. <h3>Objective</h3> To examine the risk of after diagnostic exposure. <h3>Design, Setting, and Participants</h3> This population-based cohort study included youths aged 0 to 19 years at baseline from South Korean National Health Insurance System claim records January 1, 2006, December 31, 2015. Exposure was classified as any that...
Atezolizumab plus bevacizumab (ATE+BEV) therapy has become the recommended first-line for patients with unresectable hepatocellular carcinoma (HCC) because of favorable treatment responses. However, there is a lack data on sequential regimens after ATE+BEV failure. We aimed to investigate clinical outcomes advanced HCC who received subsequent systemic disease progression ATE+BEV. This multicenter, retrospective study included started second-line sorafenib or lenvatinib progressed between...
Objectives: PD-1/PD-L1 and CTLA-4 have been investigated are thought to play an important role in tumor evasion. This study aimed investigate expression patterns of immune-related molecules, their clinical impacts malignant salivary gland tumors. Patients methods: We performed immunohistochemical staining for PD-L1, PD-L2, CTLA-4, PD-1, CD8 + tumor-infiltrating lymphocytes 70 Protein was assessed by H-score multiplying the intensity percentage cells with positive staining. Results: The...
Abstract Breast cancer is the most common among women worldwide, and it a main cause of death in women. As with breast cancer, metabolic components are important risk factors for development nonalcoholic fatty liver disease (NAFLD). In this retrospective cohort study, we aimed to determine prevalence NAFLD patients impact on prognosis cancer. Patients were enrolled study from January 2007 June 2017. Hepatic steatosis was evaluated through non-enhanced computed tomography scan by measuring...
Abstract Background: The efficacy of treating colorectal cancer (CRC) liver metastases is hindered by significant tumor heterogeneity, both within and between tumors. This diversity stems from varied cell populations complex interactions in the microenvironment, necessitating a deeper understanding spatial organization cellular communication patterns. Methods: We examined 23 formalin-fixed paraffin-embedded tissue samples 11 patients, comprising primary lesions matched metastasis (6 with...
This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive for VTE were also investigated.A total 216 diagnosed who received gemcitabine-based chemotherapy at our institution retrospectively evaluated.VTE occurred 51 (23.6%) during treatment and did not affect survival. However, beginning showed poor prognosis compared chemotherapy: all (hazard ratio [HR] 1.897, p =...
Background/Aims Patients with pancreatic cancer (PC) generally have poor clinical outcomes. Early determination of their prognosis is crucial for developing a therapeutic strategy. Recently, various inflammatory markers been validated as prognostic indicators many cancers, including PC. However, few studies evaluated these together. Thus, the purpose this study was to comprehensively evaluate value in patients advanced PC treated gemcitabine-based chemotherapy first line regimen. Methods...
Poor dental health is correlated with an increased risk of cancer. Using a nationwide population cohort database, we investigated which cancer highly associated poor and indicator mostly influences risk.This study was conducted using the National Health Checkups (NHC) Insurance System (NHIS) database in Korea. NHC Korea includes examinations. We retrieved subjects who underwent between 2002 2003 their medical information NHIS followed until December 31,2015.Data for 200,170 participated were...
Anti-programmed death 1 (PD-1) monotherapy triggers various responses by each organ. In advanced hepatocellular carcinoma (HCC), while extrahepatic lesions demonstrate objective response rates (ORR) of 20%-40%, only 10% intrahepatic respond. Although first-line atezolizumab/bevacizumab has shown survival benefits in HCC, organ-specific remain unexplored. Therefore, we aimed to assess patients with HCC receiving atezolizumab/bevacizumab.
Introduction Dupilumab is the first biological treatment for atopic dermatitis (AD). Dupilumab-associated ocular surface disease (DAOSD) one of most commonly reported side effects in patients with AD during dupilumab treatment. This study aimed to identify risk factors DAOSD a real-world setting and construct risk-scoring system predicting risk. Methods A retrospective analysis was conducted dupilumab-treated adult between April 2019 September 2023 at Yeouido St. Mary’s Hospital Korea....
The impacts of pulmonary function in patients with metastatic non-small cell lung cancer (NSCLC) and extended disease stage small (SCLC-ED) treated palliative chemotherapy remain to still be determined.Results spirometry performed 449 either IV NSCLC (n=313) or SCLC-ED (n=136) at diagnosis were reviewed retrospectively. Overall survival (OS) was estimated using the Kaplan-Meier method compared via a log-rank test. Multivariate analysis Cox proportional hazards regression model.The presence...
Head and neck cancer (HNCA) survivors have a high risk of developing cardiovascular disease (CVD) or stroke because sharing factors disease. Therefore, we investigated the CVD occurrence among HNCA in Korea based on Health Insurance Review Assessment (HIRA) Service claims database.
Anemia is a major risk factor that contributes to mortality in patients with chronic kidney disease. There controversy over the optimal hemoglobin (Hb) target these patients. This study investigated association between Hb level and cohort of hemodialysis (HD) Korea.This was multicenter prospective observational maintenance HD performed for 5 years western Seoul, Korea. Three hundred sixty-two participants were enrolled. Laboratory values accessed every 6 months. Repeated measures laboratory...
There are few radiogenomic studies to correlate ultrasound features of breast cancer with genomic changes. We investigated whether vascular phenotypes associated gene profiles for predicting angiogenesis and prognosis. prospectively correlated quantitative qualitative microvascular (vascular index, vessel morphology, distribution, penetrating vessel) contrast-enhanced (time-intensity curve parameters enhancement pattern) characteristics in 31 cancers. DNA obtained from tumors normal tissues...
Visceral larva migrans (VLM) syndrome is a clinical manifestation of systemic organ involvement by Toxocara species. VLM with the bladder and liver rare finding. A 62-year-old woman presented diffuse wall thickening multiple masses peripheral eosinophilia urinary symptoms. We considered malignancy or eosinophilic cystitis through manifestations imaging findings. However, no suspicious malignant lesions were observed on cystoscopy mass biopsy revealed presence necrotizing granuloma without...
<b><i>Background:</i></b> The efficacy of second-line chemotherapy (CT2) after the failure first-line (CT1) for advanced biliary tract cancer (BTC) has not been established. We investigated favorable prognostic factors CT2 to determine which patients could be expected benefit from CT2. <b><i>Methods:</i></b> From a total 168 who were treated with at our institution between January 2003 and December 2012, we retrospectively reviewed 50 received...
Wernicke's encephalopathy is caused by thiamine deficiency, and characterized acute mental confusion, ataxia, ophthalmoplegia. It also a rare neurologic complication of hematopoietic stem cell transplantation (HSCT). However, because its incidence, can easily be overlooked in HSCT patients, few misleading steps the early stage disease may result permanent disability or even mortality. We recently encountered case patient who underwent allogeneic HSCT. Based on our own experience previously...
Primary pericardial malignant mesothelioma (PPM) is a very rare malignancy, with an incidence of less than 0.002% and represents 5% all mesotheliomas. The cause uncertain that differ from pleural which associated asbestos exposure. This malignancy terribly aggressive has poor prognosis six months overall survival. We present case 71-year-old woman who was diagnosed cardiac tamponade caused by PPM received chemotherapy pemetrexed cisplatin for months. During two years she alive without...
It is largely unknown whether genetic susceptibility contributes to tumor immune infiltration in common cancers. We systematically investigated the association between polygenic risk scores (PRSs) and First, we constructed a PRS for cancers using variants identified previous genome-wide studies. Then, analyzed 139 traits predicted by studies examining gene expression data tissues from The Cancer Genome Atlas (TCGA). applied regression analyses evaluate associations each cancer overall...