A5085171837- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Ear and Head Tumors
- Sinusitis and nasal conditions
- Facial Nerve Paralysis Treatment and Research
- Otitis Media and Relapsing Polychondritis
- Virology and Viral Diseases
- Hearing, Cochlea, Tinnitus, Genetics
- Tracheal and airway disorders
- Ocular Diseases and Behçet’s Syndrome
- Adrenal and Paraganglionic Tumors
- Infectious Diseases and Mycology
- Nasal Surgery and Airway Studies
- Herpesvirus Infections and Treatments
- Cell Adhesion Molecules Research
- Head and Neck Surgical Oncology
- Soft tissue tumors and treatment
- Oropharyngeal Anatomy and Pathologies
- Vascular Anomalies and Treatments
- Infectious Diseases and Tuberculosis
- Bone Metabolism and Diseases
- Musculoskeletal synovial abnormalities and treatments
- Ocular Surface and Contact Lens
- Cancer-related molecular mechanisms research
- Hearing Loss and Rehabilitation
Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház
2013-2024
University of Miskolc
2014-2019
University of Debrecen
2005-2014
European Union
2012
Abstract Objectives Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with generalized localized bone loss. We conducted a comprehensive study using imaging (dual-energy X-ray absorptiometry, DXA) laboratory biomarkers in order to determine health the effects of anti-tumor necrosis factor (TNF) biologics RA AS. Patients methods Thirty-six 17 AS patients undergoing 1-year etanercept (ETN) or certolizumab-pegol (CZP) therapy were studied. Bone density was assessed...
Microbial biofilms have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). Although are characterized by an extremely high resistance against chemical and physical agents, low-frequency ultrasound (LFU) treatment has suspected to be efficient safe method for biofilm disruption.Basic science experimental study.A total 10 patients CRSwNP undergoing endoscopic sinus surgery were analyzed. Two series identical polyps (n = 20) processed hematoxylin-eosin...
Abstract Hypothesis: Otosclerosis is a bone remodeling disorder of the otic capsule causing conductive and sensorineural hearing loss. Persistent measles virus infection temporal with increased tumor necrosis factor (TNF)‐alpha decreased osteoprotegerin mRNA expression supposed to be main etiologic in otosclerosis. Background: Determinants reactive inflammation were studied The presence was shown otosclerotic patients by reverse transcriptase‐polymerase chain reaction (RT‐PCR) amplification...
Objective To estimate the correlations between high-resolution computed tomography (HRCT) scans, preoperative audiometric findings and histopathologic results in stapes ankylosis. Study Design Retrospective case review. Setting Tertiary referral center. Patients A total of 57 patients with ankylosis, who underwent unilateral stapedectomies were analyzed. Interventions Diagnostic therapeutic. Main Outcome Measures Preoperative HRCT examinations performed all cases. Findings categorized...
The cause of otosclerosis is still unknown. Persistent measles virus infection the otic capsule supposed to be one etiologic factors in otosclerosis. Chronic viral antigen expression on surface infected cells can induce a secondary autoimmune reaction against capsule.In past 15 years, some reports proposed possible role presence was shown otosclerotic patients by reverse-transcriptase polymerase chain amplification RNA, detecting proteins immunohistochemistry and antimeasles immunoglobulin G...
Otosclerotic bone is supposed to show unique CD46 expression pattern because otosclerosis an organ-specific disease with viral etiology.Otosclerosis a complex remodeling disorder of the human otic capsule, which associated persisting measles virus infection. The general cellular receptor CD46, has 14-known splicing isoforms.Nucleic acid was extracted from ankylotic stapes footplates (N = 99) removed during stapedectomies. Consecutive histological, specific immunohistologic analysis, and...
Objective . Adenoid hypertrophy is a common condition in childhood, which may be associated with recurring acute otitis media (RAOM), effusion (OME), and obstructive sleep apnea syndrome (OSAS). These different clinical characteristics have some overlap; however, they might explained by distinct immunologic infectious profiles result various histopathologic findings of adenoid specimens. Methods A total 59 children undergoing adenoidectomy were studied. Three series identical specimens...
Otosclerosis is a frequent cause of hearing impairment characterized by abnormal resorption and deposition bone in the human otic capsule. It disease complex etiopathogenesis that caused both environmental genetic factors. The goal this study to replicate association for genes were previously reported be associated with otosclerosis. However, study, patients used which presence otosclerotic foci was confirmed histologic investigation, contrast previous studies, did not use...
Abstract Background The Src family tyrosine kinases (SFK) are cellular regulatory proteins that influence cell adhesion, proliferation, invasion and survival during tumor development. Elevated activity of was associated with increased proliferation invasivity in human papillomavirus (HPV)-associated malignancies; therefore, transduced foreskin keratinocytes (HFK) were used to investigate whether SFK activation is a downstream effect papillomaviral oncoproteins. Activation ubiquitously...
Otosclerosis is a disease of unknown etiology causing conductive or sensorineural hearing loss. Persistent measles virus infection the otic capsule considered to be one etiologic factors in otosclerosis.Determinants and reactive inflammation were studied otosclerosis. The presence was shown otosclerotic patients by reverse-transcription polymerase chain reaction (RT-PCR) amplification viral RNA. No report available, however, on types features paracrine cytokines otosclerosis.Nucleic acid...
Persistent measles virus infection of the otic capsule is presumed to be one etiologic factors in otosclerosis. The viral pathogenesis otosclerosis could established only by correlative analysis: histologic examination stapes footplates and reverse-transcriptase polymerase chain reaction amplification RNA. At present, analysis removed appropriate method distinguishing otosclerotic nonotosclerotic fixations.The presence was shown patients RNA detecting proteins immunohistochemistry.Nucleic...
This study is the first to establish that bone morphogenetic protein 5 (BMP5) plays a role in pathogenesis of otosclerosis. These results confirm elevated expression levels BMPs, members transforming growth factor (TGF)-β superfamily, contribute pathologically increased turnover early, active stages otosclerosis.Otosclerosis complex remodeling disorder otic capsule, which might be characterized by different types BMPs. TGF-β and BMP are both superfamily play critical resorption new...
Abstract Hypothesis: Persistent measles virus infection of the otic capsule is suggested to be an etiologic factor in otosclerosis. Otosclerosis a disease complex unknown etiology causing progressive conductive and/or sensorineural hearing loss (HL). Background: Diagnostic methods otosclerosis are sensitive ossicular chain fixation with low specificity for otosclerotic stapes ankylosis. Methods: Nucleic acid was extracted from footplates clinically patients (N = 213). Measles nucleoprotein...
Different diseases without exact histopathologic classification can cause stapes ankylosis.Otosclerosis is a complex bone remodeling disorder of the otic capsule due to persisting measles virus infection and consecutive inflammatory reaction. In fact, clinical demographic features otosclerosis have reference ankylosis. practice, ankylosis are incorrect synonyms.Nonotosclerotic footplates (n = 284) removed during stapedectomy were analyzed histologically. Otosclerosis was excluded histologic...
Abstract Objectives/Hypothesis: Biofilms might play a potential role in the pathogenesis and high recurrence rate of chronic rhinosinusitis with nasal polyposis (CRSwNP). Biofilm persistence has been thought to correlate epithelial damage, subepithelial inflammatory cell infiltration, tumor necrosis factor‐α receptor (TNFR) expression CRSwNP. Study Design: Case‐control experimental study. Methods: A total 36 patients CRSwNP undergoing endoscopic sinus surgery were analyzed. The negative...