A5015453801- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Surgical site infection prevention
- Appendicitis Diagnosis and Management
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal disorders and treatments
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
Keio University
2021-2025
Japanese Foundation For Cancer Research
2025
University of Tsukuba
2024
Dokkyo Medical University
2024
Weatherford College
2024
Keio University Hospital
2023-2024
Mito Red Cross Hospital
2021
Neoadjuvant therapy is recommended for treating resectable pancreatic ductal adenocarcinoma (PDAC); however, its appropriate use in patients with PDAC remains debatable. This study aimed to identify independent poor prognostic factors and evaluate the clinical significance of neoadjuvant PDAC. We retrospectively reviewed consecutive diagnosed at our institute between January 2003 December 2022. analyzed time diagnosis who underwent upfront surgery using Cox proportional hazards model overall...
Alterations in KRAS, CDKN2A (p16), TP53, and SMAD4 genes have been major drivers of pancreatic carcinogenesis. The clinical course patients with cancer relation to these driver alterations has not fully characterised large populations. We hypothesised that carcinomas different combinations KRAS mutation aberrant expression CDKN2A, p53, might show distinctive recurrence patterns post-operative survival outcomes. To test this hypothesis, we utilised a multi-institutional cohort 1,146 resected...
The efficacy of next‑generation sequencing (NGS) tumor‑derived DNA from intraoperative peritoneal washing fluid (IPWF) patients with pancreatic ductal adenocarcinoma (PDAC) who intend to undergo curative resection remains unclear. aim the present study was evaluate whether genomic mutations in IPWF samples PDAC could be detected using NGS. A total 12 such were included this study. Cytology (CY) assessed and NGS performed determine these patient samples. 2 (16.7%) had a CY(+) status 1 (8.3%)...
Positive peritoneal washing cytology is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC); however, its sensitivity relatively low. This study evaluated the performance peptide nucleic acid (PNA)-directed PCR clamping as a molecular-based for sensitive detection KRAS mutation PDAC. Intraoperative fluid (IPWF) obtained from PDAC who underwent surgery was analyzed. PNA-directed performed on DNA extracted IPWF. Among 54 enrolled, threshold cycle (Ct)...
Organ/space surgical site infection (SSI) is a significant clinical problem. The postdiagnosis course of organ/space SSIs and the impact its early diagnosis on outcomes are yet to be clarified. Thus, we aimed investigate association between timing outcome SSI.This retrospective, single-center cohort study evaluated patients who underwent elective gastrointestinal or hepatopancreatobiliary surgery 2016 2020. Clinical were compared group (ie, SSI diagnosed until postoperative day [POD] 4)...
Some intraductal papillary mucinous neoplasms (IPMNs) have malignant potential and can become pancreatic cancer. The mechanism behind the progression of IPMN remains unknown. We aimed to identify risk factors interactions between backgrounds for IPMN.We retrospectively enrolled 980 patients cancer or suspected (sIPMN) who underwent endoscopic ultrasound retrograde cholangiopancreatography. classified them into cancer, high-risk sIPMN, low-risk investigated sIPMN.Smoking habits (odds ratio...
Abstract Background The clinical importance of positive peritoneal cytology results in patients with pancreatic ductal adenocarcinomas remains controversial. We evaluated the prognosis these and predictive preoperative risk factors for results. Methods retrospectively reviewed who underwent curative-intent surgery at our institution between May 2010 June 2020. Preoperative were identified using logistic regression analysis. A scoring model was constructed total number significant independent...
<title>Abstract</title> Background/Objectives: This study aimed to evaluate the safety, efficacy, and long-term outcomes of S-1-based neoadjuvant chemoradiotherapy (NACRT) in patients with resectable or borderline-resectable pancreatic ductal adenocarcinoma (PDAC). Methods retrospective included PDAC who underwent NACRT at our institute between 2010 2017. Results Forty were study, including 15 (37.5%) 25 (62.5%) PDAC. The completion resection rates 85.0% (n = 34) 67.5% 27), respectively....
This study aimed to evaluate the safety, efficacy, and long-term outcomes of S-1-based neoadjuvant chemoradiotherapy (NACRT) in patients with resectable or borderline-resectable pancreatic ductal adenocarcinoma (PDAC). retrospective included PDAC who underwent NACRT at our institute between 2010 2017. Forty were study, including 15 (37.5%) 25 (62.5%) PDAC. The completion resection rates 85.0% (n = 34) 67.5% 27), respectively. Several grade 3 adverse events observed, leukopenia (25.0%),...
Abstract Purpose: The postoperative mortality rate of distal pancreatectomy is lower than that pancreaticoduodenectomy, although persistent complications may occur after pancreatectomy. Fluid collection (FC) frequently observed pancreatectomy; however, FC occasionally progress to intra-abdominal abscess (PIAA), which requires conservative or progressive interventional treatment. This study aimed compare the status between patients with without PIAA, identify predictive factors for PIAA and...
Background: Alterations in KRAS, CDKN2A (p16), TP53, and SMAD4 genes have been major drivers of pancreatic carcinogenesis. The clinical course patients with cancer relation to the four gene alterations has not fully characterised large populations.Methods: In a multi-institutional cohort 1,146 resected cancer, we conducted droplet digital polymerase chain reaction for KRAS mutations immunohistochemistry analyses CDKN2A, expressions. We examined recurrence patterns survival times according...
症例は80歳代女性．１年前より食道裂孔ヘルニアおよび胃粘膜下腫瘍を認めていたが，症状がなく手術希望もなかったため，近医で経過観察としていた．今回貧血を主訴に当院を紹介受診した．上部消化管内視鏡検査と上部消化管造影検査では，混合型食道裂孔ヘルニアおよび体部前壁にdelleを伴った４cm大で胃内突出型の粘膜下腫瘍を認めた．胸腹部CTでは，胃穹窿部と前庭部が縦隔内に嵌入しており，さらに胃の内腔に突出するlow density massを認めた．貧血の原因は腫瘍からの出血であると判断し，腹腔鏡下胃局所切除術およびメッシュを用いた食道裂孔ヘルニア根治術を施行した．病理組織学的検査にて腫瘍径は40mmで，紡錘形腫瘍細胞が増生しており，免疫組織染色にてKITおよびCD34陽性，核分裂像400倍10視野合計１個未満であり，超低リスクGISTと診断した．今回，腹腔鏡下で同時に根治術を実施したので，若干の文献的考察を加えて報告する．