A5079443873- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Organ Transplantation Techniques and Outcomes
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Gastrointestinal Tumor Research and Treatment
- Photonic and Optical Devices
- Diet and metabolism studies
- Occupational exposure and asthma
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
Keio University
2008-2025
Keio University Hospital
2023-2025
Kansai Medical University
2024
Heidelberg University
2018-2022
Centre for Research in Engineering Surface Technology
2022
Center for Responsible Travel
2022
Groupe d'Analyse et de Théorie Economique Lyon St Etienne
2022
Centre de Recherche en Économie et Statistique
2022
Kyoto University
2012-2022
Saga University
2004-2021
The angiotensin II (AII) antagonistic action of azilsartan (AZL) [2-ethoxy-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1<i>H</i>-benzimidazole-7-carboxylic acid] was investigated in radioligand binding and function studies. AZL inhibited the specific <sup>125</sup>I-Sar<sup>1</sup>-Ile<sup>8</sup>-AII to human type 1 receptors with an IC<sub>50</sub> 2.6 nM. inhibitory effect persisted after washout free compound (IC<sub>50</sub> value 7.4 nM). Olmesartan,...
Abstract Given possible involvement of the central and peripheral angiotensin system in pain processing, we conducted clinical preclinical studies to test whether pharmacological inhibition would prevent diabetic neuropathy (DPN) accompanying type 2 diabetes mellitus (T2DM). In study, nociceptive sensitivity was determined leptin-deficient ob / mice, a T2DM model. A retrospective cohort study conducted, using medical records patients receiving antihypertensives at three hospitals for nearly...
Neoadjuvant therapy is recommended for treating resectable pancreatic ductal adenocarcinoma (PDAC); however, its appropriate use in patients with PDAC remains debatable. This study aimed to identify independent poor prognostic factors and evaluate the clinical significance of neoadjuvant PDAC. We retrospectively reviewed consecutive diagnosed at our institute between January 2003 December 2022. analyzed time diagnosis who underwent upfront surgery using Cox proportional hazards model overall...
The aim of the present study is to clarify characteristics multivisceral resection and discuss strategies for improving overall outcome locally advanced colorectal cancer.The included 323 patients who electively underwent curative surgery pT3-pT4 carcinoma without distant metastasis. We evaluated short-term long-term relative that standard operation by means multivariate analysis prognostic factors.Of patients, 53 (16.4 percent) received because adhesion other organs. Multivisceral was...
The symposium "New criteria of resectability for pancreatic cancer" was held during the 33nd meeting Japanese Society Hepato-Biliary-Pancreatic Surgery (JSHBPS) in 2021 to discuss potential modifications that could be made current classification. focused on setting foundation developing a new prognosis-based classification is based tumor biology and response neoadjuvant treatment (NAT). included selected experts from Western Eastern high-volume centers who have discussed their concept status...
We report an all-dielectric electro-optic (EO) polymer/TiO2 multilayer slot waveguide modulator with low optical insertion loss for high-speed operations. The EO polymer is sandwiched between thin TiO2 films to improve mode confinement in the polymer. structure increased and layers reduced electrode distance Au electrodes without introducing from metal electrodes. half-wave voltage of was 6.5 V a 5-mm-long at wavelength 1550 nm. length product 3.25 V·cm.
<title>Abstract</title> Background Chemotherapeutic advances have increased opportunities for conversion surgery (CS) of unresectable locally advanced (UR-LA) pancreatic cancer (PC). However, the optimal indications CS remain unclear. We aimed to identify predictive factors prognosis in UR-LA PC, and evaluate indication using these including sarcopenia. Methods In this retrospective study, we reviewed consecutive patients with PC who had received chemo(radio)therapy as an initial treatment...
Hepatopancreatoduodenectomy (HPD) is one of the most challenging surgeries for perihilar cholangiocarcinoma. Postoperative pancreatic fistula (POPF) a critical and fatal complication. The safety efficacy pancreaticogastrostomy (PG) HPD compared to pancreaticojejunostomy (PJ) remain unclear. In this study, we aimed investigate compare short-term outcomes PG PJ in terms POPF rate. Two groups patients (PG group vs. group) were retrospectively between January 2013 2024. reconstruction method was...
Hepatocyte transplantation (HCT) is a potential bridging therapy or an alternative to liver transplantation. Conventionally, single-cell hepatocytes are injected via the portal vein. This strategy, however, has yet overcome poor cell engraftment and function. Therefore, we developed orthotopic HCT method using liver-derived extracellular matrix (L-ECM) gel. PXB cells (flesh mature human hepatocytes) were dispersed into hydrogel solution in vitro, gel was immediately gelated 37°C incubators...
Turkey rhinotracheitis (TRT) virus was first isolated from a commercial broiler chicken with swollen head syndrome (SHS) in Japan. At the same time, Newcastle disease (NDV), infectious bronchitis (IBV), avian reovirus (ARV), Escherichia coli (E.coli), Morganella morganii, and Proteus mirabilis were also chicken. The presence of antibodies to TRT confirmed sera 34-day-old chickens flock SHS, however undetectable 17-day-old chickens. In this investigation, we pneumovirus infection Japan, other...