A5088377096- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- HIV Research and Treatment
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Mesenchymal stem cell research
- T-cell and Retrovirus Studies
- CRISPR and Genetic Engineering
- SARS-CoV-2 and COVID-19 Research
- Vector-Borne Animal Diseases
- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Viral Infectious Diseases and Gene Expression in Insects
- MicroRNA in disease regulation
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- CAR-T cell therapy research
- Virology and Viral Diseases
- Nanoparticle-Based Drug Delivery
- Cytomegalovirus and herpesvirus research
Pasteur Institute of Iran
2016-2025
Tehran University of Medical Sciences
2023
Biotechnology Research Center
2017
Tarbiat Modares University
2014
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2013
Institut Pasteur de Madagascar
2013
Institut Pasteur
2013
Arak University of Medical Sciences
2012
Shahid Sadoughi University of Medical Sciences and Health Services
2012
Institute of Virology of the Slovak Academy of Sciences
2009
Engineered nanoparticles are increasingly being considered for use as biosensors, imaging agents and drug delivery vehicles. Their versatility in design applications make them an attractive proposition new biological biomedical approaches. Despite the remarkable speed of development nanoscience, relatively little is known about interaction nanoscale objects with living systems. In a fluid, proteins associate nanoparticles, amount presentation on their surface could lead to different vivo...
Overexpression of DNA methyltransferase 1 (DNMT-1) is observed mostly in pancreatic cancer and it can cause tumor suppressor genes silencing this disease. Recent studies suggest that abnormal expressions microRNAs (miRs) are involved pathogenesis different types human cancers including cancer. In study we aimed to investigate the effect miR-148b -152 on reverting tumorigenic phenotype cell lines. order whether regulation DNMT-1, luciferase reporter assay was used confirmed DNMT-1 mRNA could...
Low-density lipoprotein receptor-related protein 6 (LRP6) is an important therapeutic target for diseases such as osteoporosis, Alzheimer, cancer, and neurodegenerative disease. Computational methods ligand-based structure-based virtual screening have been introduced extremely efficient accurate tool finding new drug targets candidates. In this study, we aimed to screen the National Cancer Institute (NCI) Diversity Set II parts of ZINC database by identify potential safe compounds that can...
Human T-lymphotropic virus type 1 (HTLV-I) is an important global health problem in the world mainly endemic areas of HTLV-I infection. It was previously reported that Mashhad, northeastern Iran, a new region HTLV-I. The aim this study to examine prevalence and phylogenetic analysis Sabzevar, located southeast Mashhad. In cross-sectional 1445 individuals were selected by multistage cluster sampling. Serum samples screened for anti-HTLV-I antibody using enzyme-linked immunosorbent assay...
Background As a potent CD8+ T cell activator, peptide vaccine has found its way in development against intracellular infections and cancer, but not leishmaniasis. The first step toward is epitope mapping of different proteins according to the most frequent HLA types population. Methods Findings Six Leishmania (L.) major-related candidate antigens (CPB,CPC,LmsTI-1,TSA,LeIF LPG-3) were screened for potential activating 9-mer epitopes presented by HLA-A*0201 (the HLA-A allele). Online software...
Abstract Objectives In this study, ritonavir was entrapped into solid lipid nanoparticles (SLNs) employing two production methods. The prepared SLNs were characterized and antiretroviral activity investigated for more efficient formulation. Methods Ritonavir-loaded produced by solvent emulsification evaporation (SE) double emulsion methods (DE), the effects of Tween80 poloxamer188 as external phase surfactant compared. Prepared in terms size, surface charge, entrapment efficiency (EE),...
It is observed that upregulation of DNMT3B enzyme in some cancers, including colon cancer, could lead to silencing tumor suppressor genes. MiR-339 and miR-766 have been predicted target 3′UTR gene. Luciferase reporter assay validated individual co-transfection miR-339 into the HEK293T cell reduced luciferase activity 26% ± 0.41%, 43% 0.42 64% 0.52%, respectively, compared control (P < 0.05). Furthermore, transduction expressing viruses cancer lines (SW480 HCT116) decreased expression (1.5,...
Abstract Super‐paramagnetic iron oxide nanoparticles (SPIONs) are recognized as powerful biocompatible materials for use in various biomedical applications, such drug delivery, magnetic‐resonance imaging, cell/protein separation, hyperthermia and transfection. This study investigates the impact of high concentrations SPIONs on cytotoxicity cell‐cycle effects. The interactions surface‐saturated (via with cell medium) bare those coated poly(vinyl alcohol) (PVA) adhesive mouse fibroblast cells...
The therapeutic potential of bone marrow mesenchymal stem cells (MSCs) in kidney failure has been examined some studies. However, recent findings indicate that after transplantation, these home to kidneys at very low levels. Interaction stromal derived factor-1 (SDF-1) with its receptor, CXCR4, is pivotal importance migration and homing. Recently, CXCR7 also recognized as another SDF-1 receptor interacts CXCR4 modulates functions. In this study, were separately simultaneously overexpressed...
Currently, natural products have been shown to present interesting biological and pharmacological activities are used as chemotherapeutic agents. Plants historically in treating cancer recognized for their ability produce secondary metabolites. Juglans regia L. (Juglandaceae) has medicinal applications treat a wide range of diseases such cancer.The current study was designed evaluate the antiproliferative activity total extract well several fractions from leaves J. regia.The phenolics,...
Homocysteine is a sulfur-containing amino acid which formed (mainly in the liver) during metabolism of methionine. Prior studies indicated important role hyperhomocysteinemia pathogenesis and progression alcoholic liver disease, steatosis cirrhosis. One most mechanisms by homocysteine promote development hepatic injury oxidative stress. Transcription factor Nrf2-mediated antioxidant response, represents critical cellular defense mechanism that serves to maintain intracellular redox...
Abstract Islet transplantation has been hampered by loss of function due to poor revascularization. We hypothesize that co-transplantation islets with human embryonic stem cell-derived mesenchymal stromal cells conditionally overexpress VEGF (hESC-MSC:VEGF) may augment islet revascularization and reduce the minimal mass required reverse diabetes in mice. HESC-MSCs were transduced recombinant lentiviruses allowed conditional (Dox-regulated) overexpression VEGF. HESC-MSC:VEGF characterized...
The toxicity of available drugs for treatment leishmaniasis, coupled with emerging drug resistance, make it urgent to find new therapies. Antimicrobial peptides (AMPs) have a strong broad-spectrum antimicrobial activity distinctive modes action and are considered as promising therapeutic agents. defensins, members the large family AMPs, immunomodulatory molecules important components innate immune system. Human neutrophil peptide-1 (HNP-1), which is produced by neutrophils, one most potent...