A5021875895- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Microencapsulation and Drying Processes
- Protein purification and stability
- Advancements in Transdermal Drug Delivery
- Research on Leishmaniasis Studies
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Wound Healing and Treatments
- Advanced biosensing and bioanalysis techniques
- Sperm and Testicular Function
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- Magnetic Properties and Synthesis of Ferrites
- Insect and Pesticide Research
- Reproductive Biology and Fertility
- Nanoparticle-Based Drug Delivery
- Pesticide Exposure and Toxicity
- Anesthesia and Pain Management
- biodegradable polymer synthesis and properties
- Oral health in cancer treatment
- Characterization and Applications of Magnetic Nanoparticles
- Olfactory and Sensory Function Studies
- Inflammatory mediators and NSAID effects
Shahid Sadoughi University of Medical Sciences and Health Services
2016-2025
Pharmaceutical Sciences Research Center
2022-2023
Tehran University of Medical Sciences
2012-2015
University of Tehran
2013
Abstract Background Oral mucositis (OM) is one of the main problems in almost all patients undergoing head and neck radiotherapy (RT). Owning to antioxidant anti-inflammatory properties curcumin, effect both oral topical formulations curcumin was assessed on radiation-induced OM (ROM) this study. Methods The safety efficacy mouthwash 0.1% (w/v) curcumin-nanocapsule were evaluated ameliorating severity pain/burning associated with during RT. current randomized, placebo-controlled trial...
Radiation-induced dermatitis, a common radiotherapy (RT) complication, affects 95% of breast cancer patients, with 10% experiencing severe reactions. Despite advancements, radiation dermatitis remains challenge, disrupting treatment schedules and compromising patients' quality life. Exploring herbal compounds, particularly Curcumin, has shown promise in addressing radiation-induced its non-toxic anti-inflammatory properties offering the potential for clinical trials to prevent these This...
Dry powder formulations are extensively used to improve the stability of antibodies. Spray drying is one important methods for protein drying. This study investigated effects trehalose, hydroxypropyl beta cyclodextrin (HPBCD) and (BCD) on particle properties spray-dried IgG.D-optimal design was employed both experimental analysis optimization variables. The size aerodynamic behavior particles were determined using laser light scattering glass twin impinger, respectively. In addition,...
Purpose: Recurrent aphthous stomatitis (RAS) is the most common painful ulcerative disease of oral mucosa happening in ~20% people. Aimed to develop Myrtus communis L. (Myrtle) containing patches, we applied box-behnken design evaluate effect polymers such as Polyvinyl pyrrolidone (PVP), Gelatin, Methylcellulose (MC) and Pectin. Methods: The patches properties tensile strength, folding endurance, swelling index, thickness, mucoadhesive strength pattern myrtle release were evaluated dependent...
Wound healing is crucial for maintaining healthy skin and preventing complications. Topical administration a preferred method delivering therapeutic medicines at the surgery site, as it simple, affordable, does not result in systemic harm or antibiotic resistance. Moxifloxacin (MXF), broad-spectrum with anti-inflammatory effects, seems to be effective against bacteria accelerates wound healing. This study aims determine effect of topical MXF on after laparoscopy. double-blind clinical trial...
Abstract This study aimed to develop atorvastatin‐loaded emulgel and nano‐emulgel dosage forms investigate their efficiency on surgical wound healing reducing post‐operative pain. double‐blind randomized clinical trial was conducted in a ward of tertiary care hospital affiliated with university medical sciences. The eligible patients were adults aged 18 years or older who undergoing laparotomy. participants 1:1:1 ratio one three following groups 1% ( n = 20), placebo 20) twice day for 14...
Abstract Liposome, as a drug delivery vehicle, entraps drugs, releases them sustainably, and modifies release patterns. This entrapment has diminished exposure of the to eye medium, which could minimize adverse effects. In this investigation, 18 formulations in 3 key categories (liposome, gel lipogel) cromolyn sodium (CS) were prepared evaluated water‐soluble drug. Then, liposome (L 1 ‐L 6 ) developed using thin‐film hydration method. The macroscopic microscopic assessments comprised...
Background: The aim of this study was to prepare and characterize cefixime nanosuspensions in order enhance the dissolution rate solubility drug. Methods: Nanosuspensions were prepared using sonoprecipitation method effects surfactant type, solid content, sonication power input interval acid addition on yield particle size investigated. Results: Particle optimal nanosuspension formulation 266±10 nm 35±2%, respectively. Scanning electron microscopy (SEM) results showed a nearly spherical...
Background: Although the stabilizing effects of cyclodextrins (CDs) on liquid protein formulations have been proven, there is no comprehensive data evaluation their lyophilized antibody powders. In this study, influence two CD derivatives namely beta-cyclodextrin (βCD) and hydroxypropyl (HPβCD) was compared with trehalose mannitol regarding molecular thermodynamic stability IgG as well its biological activity. Methods: Sugars were separately added to solutions lyophilization process...