A5089125041- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Cardiovascular Health and Disease Prevention
- Neurological Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Diet and metabolism studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Atomic and Subatomic Physics Research
- Nutritional Studies and Diet
- Health, Environment, Cognitive Aging
- Mindfulness and Compassion Interventions
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Ultrasound and Hyperthermia Applications
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Traumatic Brain Injury Research
- Pain Management and Placebo Effect
- Lanthanide and Transition Metal Complexes
- Ultrasound Imaging and Elastography
- Pain Mechanisms and Treatments
University of California Davis Medical Center
2025
University of California, Davis
2020-2024
Wake Forest University
2014-2023
University of California, San Diego
2008-2022
Research Institute of Radiology
2019
Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences
2014-2016
Children's National
2016
George Washington University
2016
Atrium Health Wake Forest Baptist
2014
University of Wisconsin–Madison
2005-2008
Mindfulness meditation reduces pain in experimental and clinical settings. However, it remains unknown whether mindfulness engages pain-relieving mechanisms other than those associated with the placebo effect (e.g., conditioning, psychosocial context, beliefs). To determine analgesic of are different from placebo, we randomly assigned 75 healthy, human volunteers to 4 d following: (1) meditation, (2) (3) sham or (4) book-listening control intervention. We assessed intervention efficacy using...
Long acting insulin detemir administered intranasally for three weeks enhanced memory adults with Alzheimer's disease dementia (AD) or amnestic mild cognitive impairment (MCI). The investigation of longer-term administration is necessary to determine whether benefits persist, they are similar provided by regular insulin, and either form therapy affects AD biomarkers.The present study aimed four months treatment intranasal improves cognition, daily functioning, biomarkers MCI AD.This...
The aim of this study was to determine whether the cumulative effects head impacts from a season high school football produce magnetic resonance imaging (MRI) measureable changes in brain absence clinically diagnosed concussion. Players local team were instrumented with Head Impact Telemetry System (HITS™) during all practices and games. All players received pre- postseason MRI, including diffusion tensor (DTI). Immediate Post-Concussion Assessment Cognitive Testing (ImPACT) also conducted....
Purpose To examine the effects of subconcussive impacts resulting from a single season youth (age range, 8–13 years) football on changes in specific white matter (WM) tracts as detected with diffusion-tensor imaging absence clinically diagnosed concussions. Materials and Methods Head impact data were recorded by using Impact Telemetry system quantified combined-probability risk-weighted cumulative exposure (RWECP). Twenty-five male participants evaluated for seasonal fractional anisotropy...
Mid-life dietary patterns are associated with Alzheimer's disease (AD) risk, although few controlled trials have been conducted.Eighty-seven participants (age range: 45 to 65) normal cognition (NC, n = 56) or mild cognitive impairment (MCI, 31) received isocaloric diets high low in saturated fat, glycemic index, and sodium (Western-like/West-diet vs. Mediterranean-like/Med-diet) for 4 weeks. Diet effects on cerebrospinal fluid (CSF) biomarkers, cognition, cerebral perfusion were assessed...
Pseudocontinuous arterial spin labeling (PCASL) has been demonstrated to provide the sensitivity of continuous method while overcoming many limitations that method. Because specification phases in radiofrequency pulse train PCASL defines tag and control conditions flowing blood, its tagging efficiency is sensitive factors, such as off-resonance fields, induce phase mismatches between pulses spins. As a result, quantitative estimation cerebral blood flow with can exhibit significant amount...
The purpose of this study was to determine whether the effects cumulative head impacts during a season high school football produce changes in diffusional kurtosis imaging (DKI) metrics absence clinically diagnosed concussion. Subjects were recruited from team and outfitted with Head Impact Telemetry System (HITS) all practices games. Biomechanical impact exposure calculated, including: total impacts, summed acceleration, Risk Weighted Cumulative Exposure (RWE). Twenty-four players completed...
Abstract Interindividual differences in pain sensitivity vary as a function of interactions between sensory, cognitive–affective, and dispositional factors. Trait mindfulness, characterized the innate capacity to nonreactively sustain attention present moment, is psychological construct that associated with lower clinical outcomes. Yet, neural mechanisms supporting mindfulness are unknown. In an exploratory data analysis obtained during study comparing placebo analgesia, we sought determine...
Vascular risk factors (e.g., obesity and hypertension) are associated with cerebral small vessel disease, Alzheimer's disease (AD) pathology, dementia. Reduced perfusion may reflect the impaired ability of blood vessels to regulate flow in reaction varying circumstances such as hypercapnia (increased end-tidal partial pressures CO
For millenniums, mindfulness was believed to diminish pain by reducing the influence of self-appraisals noxious sensations. Today, meditation is a highly popular and effective therapy that engage multiple, nonplacebo-related mechanisms attenuate pain. Recent evidence suggests meditation-induced relief associated with engagement unique cortico-thalamo-cortical nociceptive filtering mechanisms. However, functional neural connections supporting meditation-based analgesia remain unknown. This...
Abstract Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact late‐life brain health. Methods We examined baseline VRFs, and cognitive testing neuroimaging measures (β‐amyloid [Aβ] PET, MRI) in a diverse longitudinal cohort (N = 159; 50% African‐American, White) from Wake Forest's Multi‐Ethnic Study of Atherosclerosis Core. Results African‐Americans exhibited greater Cardiovascular Risk Factors, Aging, Incidence Dementia (CAIDE), Framingham stroke...
Abstract A method is presented for high‐resolution 3D imaging of the whole lung using inhaled hyperpolarized (HP) He‐3 MR with multiple half‐echo radial trajectories that can accelerate through undersampling. trajectory be used to reduce level artifact undersampled projection reconstruction (PR) by increasing amount data acquired per unit time HP imaging. The point spread functions (PSFs) breath‐held MRI were evaluated simulations predict effects T 2 * and gas diffusion on image quality....
Abstract The adiabatic inversion of blood in pseudocontinuous arterial spin labeling (PCASL) is highly sensitive to off‐resonance effects and gradient imperfections this sensitivity can lead tagging efficiency loss unpredictable variations cerebral flow estimates. This caused by a phase tracking error between the RF pulses flowing spins. article introduces new method, referred as Optimized PCASL (OptPCASL), that minimizes applying an additional compensation term in‐plane gradients pulse...
Abstract Glioblastoma (GBM) is the most common primary malignant astrocytoma characterized by extensive invasion, angiogenesis, hypoxia, and micrometastasis. Despite relatively leaky nature of GBM blood vessels, effective delivery antitumor therapeutics has been a major challenge due to complications caused blood–brain barrier (BBB) highly torturous newly formed tumor vasculature (blood barrier-BTB). External beam radiotherapy was previously shown be an means permeabilizing central nervous...
Arterial spin labeling (ASL) is an MRI perfusion imaging method from which quantitative cerebral blood flow (CBF) can be calculated. We present a multi-TI ASL (multi-TI integrated ASL) in variable post-labeling delays and TRs are used to improve the estimation of arterial transit time (ATT) CBF while shortening scan by 41% compared conventional methods. Variable bolus widths allow for T1 M0 raw data. Multi-TI pseudo-continuous images were collected at 7 TI times ranging 100-4300 ms....
Assessing emotional dynamics in the brain offers insight into fundamental neural and psychological mechanisms underlying emotion. One such dynamic is inertia-the influence of one's state at one time point on a subsequent point. Emotion inertia reflects rigidity poor emotion regulation as evidenced by its relationship to depression neuroticism. In this study, we assessed changes cerebral blood flow (CBF) from before after an task used these predict stress, positive negative daily life events....
Despite accruing evidence showing that positive emotions facilitate stress recovery, the neural basis for this effect remains unclear. To identify underlying mechanism, we compared recovery people reflecting on a stressor while in emotional context with neutral context. While blood-oxygen-level dependent data were being collected, participants (N = 43) performed stressful anagram task, which was followed by period during they reflected watching or video. Participants also reported and...
Abstract Pain and depressive mood commonly exhibit a comorbid relationship. Yet, the brain mechanisms that moderate relationship between dysphoric pain remain unknown. An exploratory analysis of functional magnetic resonance imaging, behavioral, psychophysical data was collected from previous study in 76 healthy, nondepressed, pain-free individuals. Participants completed Beck Depression Inventory-II (BDI), measure negative mood/depressive symptomology, provided intensity unpleasantness...
Abstract INTRODUCTION The EXERT study (Exercise in Adults with Mild Memory Problems) was a Phase 3, multicenter, randomized controlled trial that examined effects of exercise on cognition and other measures brain health sedentary older adults amnestic mild cognitive impairment (MCI). METHODS Participants were to moderate‐high intensity aerobic training (AX) or low‐intensity stretching/balance/range motion (SBR) for 18 months. Exercise supervised the first 12 Assessments administered at...
A new method for correction of MRI motion artifacts induced by corrupted k-space data, acquired multiple receiver coils such as phased arrays, is presented. In our approach, a projections onto convex sets (POCS)-based reconstruction sensitivity encoded data (POCSENSE) employed to identify samples. After the erroneous are discarded from dataset, artifact-free images restored remaining using coil profiles. The error detection and restoration based on informational redundancy phased-array may...