A5002871057- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Bone fractures and treatments
- Scoliosis diagnosis and treatment
- Innovations in Medical Education
- Connective tissue disorders research
- Wnt/β-catenin signaling in development and cancer
- Hip disorders and treatments
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Electromagnetic Simulation and Numerical Methods
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Tumors and Oncological Cases
- Bone health and treatments
- Cancer and Skin Lesions
- Surgical Simulation and Training
- Muscle Physiology and Disorders
- Diversity and Career in Medicine
- Spinal Fractures and Fixation Techniques
- Neurogenetic and Muscular Disorders Research
Duke University
2016-2025
Duke University Hospital
2014-2025
Duke Medical Center
2015-2025
Media Working Group
2024
Hospital for Sick Children
2011-2023
University of Toronto
2012-2023
Duke University Health System
2018-2023
Orthopedic One
2023
First Affiliated Hospital of Xi'an Jiaotong University
2022
Institute of Cell Biology
2021
Despite significant interest in developing quantum dots (QDs) for biomedical applications, many researchers are convinced that QDs will never be used treating patients because of their potential toxicity. The perception toxic is rooted two assumptions. Cadmium-containing can kill cells culture. Many then assume to cells, they must humans. In addition, classify as a homogeneous group materials. Therefore, if CdSe harmful, extrapolate this result all QDs. Though unsubstantiated, these...
Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve repair would substantially patient outcome. The signaling pathways regulating bone are beginning be unraveled, they provide clues into pharmacologic management. beta-catenin pathway, which activates T cell factor (TCF)-dependent transcription, has emerged as a key regulator in embryonic skeletogenesis, positively osteoblasts. However, its role is...
ABSTRACT Macrophages are activated in inflammation and during early phases of repair processes. Interestingly, they also present bone development, but their function this process is unclear. Here, we explore the macrophages growth, using transgenic mice to constitutively or conditionally deplete macrophages. Depletion led skeletal growth retardation progressive osteoporosis. By 3 months age, macrophage-deficient displayed a 25% reduction mineral density 70% number trabecular compared control...
Background: Pain is one of the most common and distressing symptoms reported by adolescents with cancer. Despite advancements in pain assessment management research, due to cancer and/or its treatments continues be poorly managed. Our research group has developed a native iPhone application (app) called Squad tackle problem managed adolescent group. The app functions as an electronic diary unique ability collect data on intensity, duration, location, impact adolescent's life (ie,...
Integrin-mediated force application induces a conformational change in latent TGF-β1 that leads to the release of active form growth factor from extracellular matrix (ECM). Mechanical activation is currently understood as an acute process depends on contractile cells. However, we show ECM remodeling, preceding step, mechanically primes akin loading mechanical spring. Cell-based assays and unique strain devices were used produce cell-derived controlled organization prestrain. Mechanically...
A significant challenge to delivering therapeutic doses of nanoparticles targeted disease sites is the fact that most become trapped in liver. Liver-resident macrophages, or Kupffer cells, are key cells hepatic sequestration nanoparticles. However, precise role macrophage phenotype plays nanoparticle uptake unknown. Here, we show human modulates hard uptake. Using gold nanoparticles, examined by monocyte-derived macrophages had been driven a "regulatory" M2 an "inflammatory" M1 and found...
Abstract The capacity for tissues to repair and regenerate diminishes with age. We sought determine the age-dependent contribution of native mesenchymal cells circulating factors on in vivo bone repair. Here we show that exposure youthful circulation by heterochronic parabiosis reverses aged fracture phenotype diminished osteoblastic differentiation old animals. This rejuvenation effect is recapitulated engraftment young haematopoietic into During rejuvenation, β-catenin signalling, a...
Fibroproliferative processes are a group of disorders in which there is excessive proliferation spindle (mesenchymal fibroblast-like) cells. They range from hypertrophic scars to neoplasms such as aggressive fibromatosis. Cells these share cytologic similarity with fibroblasts present during the proliferative phase wound healing, suggesting that they represent prolonged wounding response. A critical role for β-catenin mesenchymal cells fibroproliferative suggested by its high rate somatic...
Scoliosis is a spinal deformity consisting of lateral curvature and rotation the vertebrae. The causes scoliosis vary are classified broadly as congenital, neuromuscular, syndrome-related, idiopathic due to secondary reasons. majority cases encountered by general practitioner will be idiopathic. natural history relates etiology age at presentation, usually dictates treatment. However, it patient's history, physical examination radiographs that critical in initial evaluation scoliosis,...
Abstract Although many cancers are maintained by tumor-initiating cells, this has not been shown for mesenchymal tumors, in part due to the lack of unique surface markers that identify progenitors. An alternative technique isolate stem-like cells is side population (SP) based on efflux Hoechst 33342 dye. We examined 29 tumors ranging from benign high-grade sarcomas and identified SP all but six samples. There was a positive correlation between percentage grade tumor. preferentially formed...