A5009660278- RNA modifications and cancer
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Pain Management and Placebo Effect
- Epigenetics and DNA Methylation
- Infectious Diseases and Tuberculosis
- Cardiac and Coronary Surgery Techniques
- Cancer Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Music Therapy and Health
- RNA Research and Splicing
- Aortic Thrombus and Embolism
- Tracheal and airway disorders
- Genetic factors in colorectal cancer
- Head and Neck Surgical Oncology
Zhujiang Hospital
2018-2025
Southern Medical University
2012-2025
The long non-coding RNA (lncRNA) HOX transcript antisense (HOTAIR) serves as a powerful predictor of tumor progression and overall survival in patients. Our previous studies showed that HOTAIR modulated HOXA1 DNA methylation by reducing DNMT1 DNMT3b expression drug-resistant small cell lung cancer (SCLC). Moreover, H3 lysine 27 trimethylation (H3K27me3) is catalyzed enhancer zeste homolog 2 (EZH2) plays critical role SCLC chemoresistance. However, it not completely clear whether H3K27me3...
Small cell lung cancer (SCLC) is a devastating and aggressive neuroendocrine carcinoma characterized by high cellular proliferation early metastatic spread. Numerous studies have demonstrated that long noncoding RNAs (lncRNAs) can regulate tumor generation development, including in SCLC. The current study aimed to assess the effect of lncRNA, KCNQ1OT1, on proliferation, apoptosis, chemoresistance SCLC potential underlying molecular mechanism.Matched chemo-resistant sensitive cells were...
Abstract Objective This study aimed to evaluate the effects of graded motor imagery (GMI) on fear movement, pain, and rehabilitation in patients with kinesiophobia after video‐assisted thoracoscopic surgery (VATS) for lung cancer. Methods Fifty‐eight participants VATS were randomly assigned into two groups: one receiving usual care (the control group) other plus GMI group). The was delivered three stages: left/right limb identification, imagery, mirror therapy by researchers every afternoon...
ABSTRACT Cisplatin (DDP) resistance in non‐small cell lung cancer (NSCLC) is a common cause of treatment failure and significant contributor to increased mortality. To tackle this issue, the integration traditional Chinese medicine with chemotherapy has been proposed as promising approach. The potential synergistic effect combining polyphyllin VII (PPVII) DDP overcoming NSCLC cells not thoroughly investigated yet. In study, H1299 were exposed gradient concentrations PPVII determine their 50%...
Lung adenocarcinoma (LUAD) is the most common malignant cancer in humans and because of low long-term survival rates, exploration molecular mechanisms underlying its progression, as well novel prognostic predictors, urgently needed. B3GNT3, a type II transmembrane protein located Golgi apparatus, essential for forming extended core 1 oligosaccharides reportedly involved transformation.The Cancer Genome Atlas (TCGA) GSE68465 were used to analyze expression B3GNT3 LUAD normal tissues overall...
A preoperative understanding of the thoracic anatomy patients with quadrivial pattern branching right upper lobe is key to successful surgery. We analyzed division bronchus using three-dimensional (3D) computed tomography (CT) angiography and bronchography.A total 212 consecutive adult who had undergone CT scans before surgery at Zhujiang Hospital Southern Medical University from August 2020 2021 was used for retrospective study. The 3D-CT images were taken Mimics software. Radiology...
Postoperative adjuvant therapy for esophageal squamous cell carcinoma (ESCC) primarily includes chemotherapy and chemoradiotherapy. The survival benefits of postoperative R0-resected ESCC remain controversial. Immunotherapy is being gradually applied perioperatively cancer, but the efficacy immunotherapy in unclear. This study aimed to evaluate effectiveness cancer. Toward this goal, we explored differences between combined with alone.
Small cell lung cancer (SCLC) is characterized by poor differentiation, high malignancy and rapid growth fast, short double time, early extensive metastatic malignancy. In clinical, chemotherapy the main treatment method, while resistance to multiple drugs in six nine months has been a major clinical challenge SCLC treatment. Therefore, It important value building aninimal model which similar patients with SCLC. Animal of xenotransplantation (PDX) from small can well retain characteristics...
Non-small cell lung cancer (NSCLC) has the highest mortality rate in world, but currently there is no effective method of dynamic monitoring. Gene mutation an important factor tumorigenesis and can be detected using high-throughput sequencing technology. This study aimed to analyze driving genes tumor NSCLC patients by whole exon sequencing, compare subclones at different time points.We collected 87 cases tissues, para-cancer peripheral blood samples for detecting cell-free DNAs (cfDNAs)...
Background: Esophageal cancer leads to the majority of deaths in world. Surgery, radiotherapy and chemotherapy are main treatment methods, but due its high recurrence metastasis rate, overall prognosis is poor. Poly(A)-specific ribonuclease (PARN) a multifunctional enzyme molecule, which involved occurrence development tumors. This study explores relationship between PARN proliferation, esophageal cancer. Methods: The tissues adjacent normal were collected from 91 patients with after...