A5090920321- Semiconductor materials and devices
- Advancements in Semiconductor Devices and Circuit Design
- Complement system in diseases
- Perovskite Materials and Applications
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Ferroelectric and Negative Capacitance Devices
- Adenosine and Purinergic Signaling
- Advanced MEMS and NEMS Technologies
- Immune Cell Function and Interaction
- Quantum Dots Synthesis And Properties
- Copper Interconnects and Reliability
- Force Microscopy Techniques and Applications
- Adhesion, Friction, and Surface Interactions
- Nanowire Synthesis and Applications
- Low-power high-performance VLSI design
- Conducting polymers and applications
- VLSI and Analog Circuit Testing
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced Surface Polishing Techniques
- Electrical Contact Performance and Analysis
- Microwave Dielectric Ceramics Synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Erythrocyte Function and Pathophysiology
- Pancreatitis Pathology and Treatment
National Yunlin University of Science and Technology
2023-2024
China Medical University
2014-2024
China Medical University Hospital
2014-2024
National Yang Ming Chiao Tung University
2023
University of California, Los Angeles
2021
Xilinx (United States)
2015-2021
University of California, Berkeley
2012-2015
National Chiayi University
2011
Chang Bing Show Chwan Memorial Hospital
2009
University of Illinois Urbana-Champaign
2009
Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased elimination half-life, allowing an extended dosing interval two to eight weeks. Here we evaluate the efficacy and safety of ravulizumab in adults atypical hemolytic uremic syndrome presenting thrombotic microangiopathy. In this global, phase 3, single arm study complement inhibitor-naïve (18 years older) who fulfilled diagnostic criteria for syndrome, enrolled patients received through 26-week initial...
Background and objectives Patients with CKD can benefit from an increase in physical activity. Walking is one of the most common exercises patients CKD; however, association walking outcomes not clear. This study investigated overall mortality RRT stages 3–5. Design, setting, participants, & measurements All 3–5 program China Medical University Hospital June 2003 to May 2013 were enrolled. The risks analyzed using competing-risks regressions. Results A total 6363 (average age, 70 years)...
IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare, complex, multisystem disease of dysregulated complement activity, characterized by progressive thrombotic microangiopathy (TMA), acute kidney injury, and multiorgan dysfunction, which often progresses to chronic disease. Results from the prospective clinical trial ravulizumab (NCT02949128) reveal rapid resolution TMA in patients with aHUS, sustained efficacy safety 26-week initial evaluation period.MethodsThe aim this analysis...
2-Hydroxy-2-methylpropiophenone (HMPP) and pentaerythritol triacrylate (PETA) are introduced into the perovskite layer via an antisolvent to enhance photovoltaic performance of solar cells (PSCs) fabricated in a moisture atmosphere. Interestingly, free radicals created from decomposition HMPP PETA by irradiating UV light can effectively patch pinholes regrow crystal enlarge grain size. interact with Pb atoms its lone pairs electrons forms framework over situ polymerization, resulting low...
A age- and sex-matched case-control radiographic study.To identify the predisposing factors of degenerative spondylolisthesis (DS).None radiologic methods for predicting development DS are very reliable or readily accessible. The commonly used computed tomography magnetic resonance imaging.Data were gathered retrospectively on middle-aged women with lumbar spondylolisthesis.The most common slipped vertebra was L4 (63.64%) second L5 (13.64%). Most parameters, including disc height, body angle...
Three-dimensional (3-D) nano-electro-mechanical (NEM) switches (relays) are proposed to reduce the die area and power consumption of digital logic memory circuits.
We synthesized core–shell upconversion nanoparticles (UCNPs) with a composition of LiYF4:Yb0.2/Er0.02/Ho0.02/Tm0.02@LiYF4:Yb0.2 and incorporated them into the photoanodes dye-sensitized solar cells (DSSCs) fabricated through low-temperature process. The as-prepared hydrophobic UCNPs displayed good protection ability to prevent ingress electrolyte but caused cracking in mesoporous layers. To resolve this issue, we modified by performing ligand exchange using 4-aminobenzoic acid (4ABA),...
Previous study on association between pro-inflammatory cytokines and mortality in PD population is limited. We aimed to investigate here.Total 50 patients who underwent incident were enrolled this study. measured the titers of Interleukin-18(IL-18), Interleukin-6 (IL-6), Interleukin-1ß (IL-1ß). Study outcomes all-cause mortality, cardiovascular-related infection-caused mortality. Cox-regression model was used.In 7 year prospective study, IL-18 ≥ 804.3pg/ml, IL-6 3.92 pg/ml, IL-1ß 0.86pg/ml,...
We introduce a compact model for the temperature distribution in cylindrical nanowire (NW) phase-change memory (PCM) cells both transient (nanoseconds) and steady-state time scales. The takes advantage of symmetry cell to efficiently calculate dependence on geometry material/interface properties. results are compared with data from literature finite-element simulations, showing improved computation speed by two orders magnitude. Programming current sensitivity dimensions material properties...
This paper describes the micro-architectural and circuit design techniques for building complex VLSI circuits with micro-electromechanical (MEM) relays presents experimental results to demonstrate viability of this technology. By tailoring micro-architecture relay device characteristics, performance relay-based multiplier is improved by an order magnitude over any known static CMOS style implementation, ~4x pass-gate equivalent implementations. A 16-bit shown offer ~10x lower energy per...
Micro-electro-mechanical relays are of interest for low-power digital integrated circuits, due to their ideally zero OFF-state leakage current. The first relay-based circuits utilized tungsten (W) as the contacting material because its excellent resistance physical wear. However, W oxidizes easily so that contact increases an unacceptably high level over device operating lifetime. Ruthenium (Ru) is a promising alternative electrode it forms electrically conductive native oxide. In this work,...
The effect of the body bias voltage on logic relay performance is investigated. switching hysteresis voltage, which sets a lower limit for operating experimentally found to decrease with increasing due reduced surface adhesive force. It demonstrated that energy can be by biasing, at tradeoff increased mechanical turn-ON delay. Simulations nanoscale designs indicate biasing used mitigate manufacturing challenges, while enabling ultralow-voltage (sub-100 mV) operation relatively fast speed.
An analytical model is developed to assess the switching energy of a nanomechanical switch. Alternative switch designs are proposed leverage spring-restoring force counterbalance surface adhesion force, reducing depth potential well created by contact and thereby overcoming limit.
Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening thrombotic microangiopathy. Definitive biomarkers for disease diagnosis and activity remain elusive, making the exploration of molecular markers paramount. We conducted single-cell sequencing on peripheral blood mononuclear cells from 13 aHUS patients, 3 unaffected family members 4 healthy controls. identified 32 distinct subpopulations encompassing 5 B-cell types, 16 T- natural killer (NK) cell 7 monocyte other types....
Multi-functional digital logic circuits, each utilizing only two relays, are demonstrated for the first time. This work can be extended to relay designs comprising greater than input electrodes and/or sets of source/drain electrodes, more compact realization zero-leakage ICs in future.
Since mechanical switches (relays) have zero off-state leakage and perfectly abrupt ON/OFF switching behavior, in principle they can be operated with a very small voltage swing overcome the energy efficiency limit of CMOS technology. This paper discusses recent developments to address remaining technical challenges for fully realizing promise ultra-low-power computing.
The energy efficiency of CMOS technology is fundamentally limited by transistor off-state leakage (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OFF</sub> ). Mechanical switches have zero I and therefore could be advantageous for ultra-low-power digital logic applications. This paper discusses recent advancements in relay switch current challenges which must addressed to realize its promise.
A compact microelectromechanical (MEM) switch design and associated family of logic gates, memory cells, other basic very-large-scale integration (VLSI) digital circuit sub blocks are proposed to ensure zero crowbar current in addition leakage while minimizing mechanical delay. The methodology introduced this paper also provides for lower device count hence operating power consumption. prototype the MEM is demonstrated.