A5010628627- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Organoboron and organosilicon chemistry
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Machine Learning in Materials Science
- Catalytic Processes in Materials Science
- Computational Drug Discovery Methods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Metabolomics and Mass Spectrometry Studies
- Asymmetric Synthesis and Catalysis
- Fluorine in Organic Chemistry
- Synthetic Organic Chemistry Methods
Princeton University
2013-2018
Princeton Public Schools
2016
University of Delaware
2012
A bright outlook for carbon coupling In contemporary organic chemistry, it is straightforward to forge bonds between unsaturated carbons (i.e., already engaged in double bonds) using cross-coupling catalysis. The protocol runs into some trouble, however, if one or both starting centers are saturated (purely single-bonded). Tellis et al. and Zuo independently found that combining a second, light-activated catalyst with nickel could achieve selective of reagents (see the Perspective by...
A guide for catalyst choice in the forest Chemists often discover reactions by applying catalysts to a series of simple compounds. Tweaking those tolerate more structural complexity pharmaceutical research is time-consuming. Ahneman et al. report that machine learning can help. Using high-throughput data set, they trained random algorithm predict which specific palladium would best isoxazoles (cyclic structures with an N–O bond) during C–N bond formation. The predictions also helped analysis...
Through fine-tuning of reagent and base structure, sulfonyl fluorides can efficiently fluorinate diverse classes alcohols. We show that machine learning map the intricate reaction landscape enable accurate prediction high-yielding conditions for untested substrates.
We describe the functionalization of α-amino C-H bonds with aryl halides using a combination nickel and photoredox catalysis. This direct C-H, C-X coupling uses inexpensive readily available starting materials to generate benzylic amines, an important class bioactive molecules. Mechanistically, this method features arylation radicals mediated by catalyst. reactivity is demonstrated for range N-aryl orthogonal scope existing activation methodologies. also report reactions several complex...
Installing silicon is easy! A high-yielding protocol for the palladium-catalyzed silylation of terminal alkenes reported. This method allows facile conversion styrenes to E-β-silyl by using iodotrimethylsilane (TMSI) or chlorotrimethylsilane/lithium iodide (see scheme). Terminal allyl silanes with good E/Z ratios are also readily accessed from α-olefins.
Quinolinium ions are engaged in an asymmetric, Ni-catalyzed Suzuki cross-coupling to yield 2-aryl- and 2-heteroaryl-1,2-dihydroquinolines. Key the development of this method is use a Ni(II) precatalyst that activates without need for strong reductants or high temperatures. The Ni–iminium activation mode demonstrated as exceptionally mild pathway generate enantioenriched products from racemic starting materials.
So leicht ist Silylieren! Eine palladiumkatalysierte Silylierung endständiger Alkene mit Silylhalogeniden wird beschrieben. Styrole werden durch Einwirkung von Iodtrimethylsilan (TMSI) in E-β-Silylstyrole umgewandelt (siehe Schema), und auch endständige Allylsilane sind guten E/Z-Verhältnissen aus α-Olefinen erhältlich.
Abstract The new presented combination of photoredox catalysis and nickel provides an alternative cross coupling procedure.
Abstract The use of BPP is the key for title synthesis.