A5005991368- Neurotransmitter Receptor Influence on Behavior
- Catalytic Processes in Materials Science
- Electrocatalysts for Energy Conversion
- Catalysis and Hydrodesulfurization Studies
- Electrochemical Analysis and Applications
- Advanced Chemical Physics Studies
- Catalysis and Oxidation Reactions
- Molecular Junctions and Nanostructures
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Metal and Thin Film Mechanics
- Diet and metabolism studies
- Advanced Chemical Sensor Technologies
- Optical Coatings and Gratings
- Advanced Photocatalysis Techniques
- Ginseng Biological Effects and Applications
- nanoparticles nucleation surface interactions
- Delphi Technique in Research
- Transcranial Magnetic Stimulation Studies
- Neurogenesis and neuroplasticity mechanisms
- Electronic and Structural Properties of Oxides
- Diamond and Carbon-based Materials Research
- Hearing, Cochlea, Tinnitus, Genetics
- Zebrafish Biomedical Research Applications
Center for Excellence in Brain Science and Intelligence Technology
2023-2025
Chinese Academy of Sciences
1997-2025
Beijing University of Chemical Technology
2025
Qufu Normal University
2025
Advanced Research Institute
2025
Shanghai Mental Health Center
2023
Shanghai Jiao Tong University
2023
Shanghai Center for Brain Science and Brain-Inspired Technology
2023
Kunming Institute of Zoology
2016-2018
University of Chinese Academy of Sciences
2014-2016
A recently established link between formaldehyde, a methanol metabolite, and Alzheimer's disease (AD) pathology has provided new impetus to investigate the chronic effects of exposure. This paper expands this investigation non-human primate, rhesus macaque, through feeding young male monkeys with 3% ad libitum. Variable Spatial Delay Response Tasks found that led persistent memory decline in lasted 6 months beyond regimen. change coincided increases tau protein phosphorylation at residues...
Although methanol toxicity is well known for acute neurological sequelae leading to blindness or death, there a new impetus investigate the chronic effects of exposure. These include recently established link between formaldehyde, metabolite, and Alzheimer's disease (AD) pathology. In present study, mice were fed with revisit toxicity, especially as it pertains AD progression. Three groups (n = 9) given either water control solution (concentrations 2% 3.8%) over 6-week period. The...
Background: Formaldehyde (FA) has been implicated in Alzheimer’s disease (AD) pathology as an age-related factor and a protein cross-linker known to aggregate Amyloid-Beta (Aβ) tau vitro. Higher levels of FA have also found patients with greater cognitive impairment AD patient brains. Objective: To directly evaluate the effect chronically elevated on primate brain respect pathological markers. Method: Young rhesus macaques (5-8 yrs, without related mutations) were given chronic...
Abstract Background Substance use disorders (SUD) refer to a group of chronic relapsing disease the brain, which is manifested by forced procuring drugs or stimulants, losing control when limiting drug intake and producing persistent negative emotional status, disappears stimulants are obtained again. SUD model specific animal behavior model, could reflect neurobiology, psychology, etiology, clinical therapeutics characteristics, at least simulate one some aspects SUD. However, great species...
This work offers a potential pathway to upcycle Ni-containing wastewater into valuable electrocatalyst.
Mg2Si-based compounds are cost-effective and environmentally friendly thermoelectric materials. However, the current Mg2(Si,Sn) solid solutions still suffer from low figure of merit zT (or energy conversion efficiency), especially averaged value (zTavg < 1.0). In this study, we synthesize Mg2(Si0.3Sn0.7)1–xSbx (x = 0, 0.5, 0.75, 1, 1.5%) through combination high-pressure, high-temperature (HPHT) synthesis spark plasma sintering (SPS). The high-pressure instrument effectively inhibits...
Here, we examine whether neurons differentiated from transplanted stem cells can integrate into the host neural network and function in awake animals, a goal of cell therapy brain. We have developed technique which small "hole" is created inferior colliculus (IC) rhesus monkeys, then are situ to allow for investigation their integration auditory network. found that some mature formed synaptic input/output connections with neurons. In addition, c-Fos expression increased significantly after...
Many studies have reported that methanol toxicity to primates is mainly associated with its metabolites, formaldehyde (FA) and formic acid. While metabolism toxicology been best studied in peripheral organs, little study has focused on the brain no experimental evidence demonstrates transformation of into FA primate brain. In this study, three rhesus macaques were given a single intracerebroventricular injection investigate whether metabolic process occurs nonhuman Levels cerebrospinal fluid...
Background Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there lack research with longitudinal design on changes plasma BDNF levels active METH-dependent individuals. Aims The aim the study was investigate during self-administration monkeys. Methods This measured three male rhesus monkeys continuous exposure four control without exposure. Changes were then assessed...
Relapse to drug use is a major clinical challenge in the treatment of addictive disorders, including psychostimulant and may be exacerbated by reduced sensitivity natural, non-drug reward. Given relatively limited set outcomes, short withdrawal time rodent studies, we conducted more detailed assessment response natural rewards methamphetamine (METH) naive versus exposed monkeys during long-term abstinence.
Summary The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs abuse. Here, we tested whether caudal part multisensory posterior insula ( PI ) stores somatosensory‐associated rewarding memories. Using Sprague Dawley rats as subjects, first established a morphine‐induced conditioned place preference CPP paradigm, mainly based on somatic cues. Secondly, electrolytic lesion portion was carried out before and after establishment ,...
Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric that affects ∼2%-3% of the population globally. Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding disorder. In large rhesus monkey colonies, we found 10 monkeys spontaneously exhibiting persistent sequential motor (SMBs) individual-specific sequences were repetitive, time-consuming stable over prolonged periods. Genetic analysis revealed severely damaging mutations genes...
Chronic methamphetamine (METH) use, a prevalent psychostimulant, is known to impair attention, yet the cellular mechanisms driving these deficits remain poorly understood. Here, we employed rat model of repeated passive METH injections and evaluated attentional performance using 5-choice serial reaction time task (5-CSRTT). Using single-nucleus RNA sequencing, immunofluorescence in situ hybridization, characterized response neurons reticulotegmental nucleus (RtTg) exposure. Our results...
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