A5060286246- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Sarcoma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Family Support in Illness
- Acute Myeloid Leukemia Research
- Neuroblastoma Research and Treatments
- Cardiac tumors and thrombi
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Renal and related cancers
- BRCA gene mutations in cancer
- Lymphoma Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Management of metastatic bone disease
- Neutropenia and Cancer Infections
- DNA Repair Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Pediatric Pain Management Techniques
- Immunodeficiency and Autoimmune Disorders
- Vascular Tumors and Angiosarcomas
- Tumors and Oncological Cases
- Medical Imaging and Pathology Studies
- Congenital Diaphragmatic Hernia Studies
Lund University
2014-2025
Skåne University Hospital
2016-2025
Getinge (Sweden)
2022
Plasma Controls (United States)
2015
Kristianstad University
2011
Klinikum Stuttgart
2008
Uniwersytecki Szpital Dziecięcy
2008
Olgahospital
2008
Katharinenhospital
2008
Goethe University Frankfurt
2008
To explore the effect of high-dose ifosfamide in first-line treatment for patients < or = 40 years age with nonmetastatic osteosarcoma extremity.From March 1997 to September 2000, 182 were evaluated. Primary consisted two blocks (15 g/m2), methotrexate (12 cisplatin (120 mg/m2), and doxorubicin (75 mg/m2). Postoperatively, received cycles (90 three each ifosfamide, methotrexate, 150 Granulocyte colony-stimulating factor support was mandatory after ifosfamide/cisplatin/doxorubicin...
When a child is ill with cancer, this affects the whole family for long periods. The aim of study was to elucidate family's lived experience when in diagnosed cancer. A descriptive inductive design hermeneutic phenomenological approach including interviews 17 families (parents, children, and siblings) chosen. families' described as 2-fold essential theme comprising "a broken life world" an immediate "striving survive." secure everyday disappeared replaced by fear, chaos, loneliness. striving...
Abstract. Nine young, healthy male volunteers were given ethanol (75 g/day) for 5 weeks. The was divided into five daily doses and taken so that blood levels never exceeded 0.04% (w/v). During the latter part of intake period, there a significant, transient increase plasma triglyceride (TG) concentrations followed by reduction to normal levels. A three‐fold lipoprotein lipase activity (LLA) occurred in biopsy specimens adipose tissue. An α‐lipoprotein concentrations, which correlated...
Abstract A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with predilection for midline head and neck thoracic structures. The clinical course invariably fatal, spite intensive chemotherapy radiotherapy. We here present successful treatment 10‐year‐old boy who presented BRD4/NUT‐positive undifferentiated iliac bone. patient was selected combined...
Evaluation of primary tumor-, treatment-, and patient-related factors predicting relapse pattern, risk, survival after with the aim to design a risk-adapted, tumor-directed surveillance program for patients localized rhabdomyosarcoma (RMS).One thousand one hundred sixty-four nonmetastatic RMS achieved complete remission at end multimodal therapy in consecutive trials Cooperative Weichteilsarkom Studiengruppe (CWS)-81, CWS-86, CWS-91, CWS-96 between 1980 2002 (median follow-up, 5 years)....
Pediatric cancer treatment may imply an increased risk of hypogonadism, leading to metabolic disorders and osteoporosis. Such complications are potentially preventable.The aim this study was assess diagnosis- treatment-dependent hypogonadism in male childhood survivors (CCS).Male CCS who were treated during the period 1970-2002 2004 18-45 yr age eligible.The conducted a university hospital clinic.A consecutive group at Lund University Hospital selected for study, whom 151 (38%) agreed...
Childhood cancer survivors (CCS) have an increased risk of impaired spermatogenesis, but data regarding the disease- and treatment-related factors azoospermia are scarce. Such information is crucial both for counselling CCS selecting patients testicular tissue cryopreservation. The proportion azoospermic men in was 18% [95% confidence interval (CI): 12-26], specifically leukaemias (19%; 95% CI: 5.5-42), Hodgkin's disease (53%; 29-76), non-Hodgkin's lymphoma (11%; 0.28-48) 0.28-48). In...
Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and mortality. The aim the pan-European PanCare Adolescent Cancer Survivor Care Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence risk factors for these effects among childhood in Europe. This paper describes methodology collection overall PanCareSurFup cohort outcome-related cohorts. In 13 providers 12 countries delivered centre Mainz. Data used single...
Abstract Thirty‐three osteosarcomas (OS) were analyzed cytogenetically. Clonal chromosome changes detected in 17 cases. Six tumors had numbers the diploid range, 6 triploid 1 tetraploid range and pentaploid while 3 multiple clones with different ploidy levels. Including present tumors, a total of 27 OS clonal aberrations have been reported. The recognizable structural rearrangements these clustered to arms 1p, 1q, 3p, 3q, 7q, 11p, 17p 22q. Chromosome bands 1q11, 1q21, 1q42 7q11 most...
Summary The translocation t(8;16) (p11;p13) was found as the sole deviation from normal karyotype in three patients with acute monocytic leukaemia. bone marrow morphology strikingly similar two cases where smears were available for re‐evaluation: leukaemic cells showed signs of differentiation, and active erythrophagocytosis a particularly conspicuous feature. We suggest that represents new consistent abnormality leukaemia, specifically associated differentiated subtype (M5b) pronounced...
We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For first time, we satisfactorily address beyond 40 years from diagnosis age among all survivors. This largest-ever assembled cohort comprises 69 460 five-year survivors diagnosed before 20 years. Standardized incidence ratios, absolute excess risks, multivariable-adjusted relative were calculated. All statistical tests two-sided. Overall, 21.65 times (95% confidence...
Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks specific STS histological subtypes unknown. We quantified after types childhood cancer. pooled data from 13 European cohorts, yielding a cohort 69 460 five-year Standardized incidence ratios (SIRs) and absolute excess (AERs) were calculated. Overall, 301 developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] 14.0 to 17.6). The highest standardized for malignant...
BJÖRK M., NORDSTRÖM B., WIEBE T. & HALLSTRÖM I. (2010) European Journal of Cancer Care20, 163–169 Returning to a changed ordinary life – families' lived experience after completing child's cancer treatment The aim the study was illuminate treatment. took place at University Hospital in southern Sweden. Interviews were carried out with 10 mothers, eight fathers, four patients and two siblings from total families. interviews analysed hermeneutical phenomenological approach. One essential theme...
The aim of this study was to investigate long-term development hearing in subjects who had received platinum-based chemotherapy childhood or adolescence. Another assess the self-reported loss handicap and compare it audiometric measurements. Medical records from individuals diagnosed with cancer treated between 1985 2000 at University Hospital Lund Sweden were reviewed retrospectively. Fifteen subjects, fulfilled eligibility criteria set for study, underwent a thorough evaluation. results...
Abstract Background Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years uncertain. We quantified these in largest ever cohort. Methods Using data from 69,460 5-year childhood (diagnosed 1940–2008), across Europe, standardized incidence ratios (SIRs) cumulative were calculated. Results In total, 279 glioma 761 meningioma identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) leukaemia 11.2, 8.8, 14.2) greatest glioma. The SIR for was...
Twenty-eight cases of hepatitis C virus (HCV) infection were identified in children a pediatric oncology ward during 2 nosocomial outbreaks. HCV spontaneously cleared 6 patients (21%). Eleven with persistent viremia who had malignant diseases remission after treatment given 48-week course combined therapy interferon-alpha (5x106 U 3 times weekly) and oral ribavirin (15 mg/kg/d). Seven (64%) the 11 sustained virological responses 12 months cessation therapy. Side effects common but generally...
Determination of D-arabinitol/L-arabinitol ratios (referred to as D/L-arabinitol ratios) in urine a tool for the diagnosis invasive candidiasis was investigated prospective study comprising 100 children with cancer. The analyses were made by gas chromatography. Positive found 10 confirmed candidiasis, 12 23 patients undergoing empiric antifungal chemotherapy, and 4 67 not receiving treatment. D/L-Arabinitol positive 3 31 days (median, days) before first culture-positive blood sample drawn or...