A5059564095- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Fibroblast Growth Factor Research
- Proteoglycans and glycosaminoglycans research
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Plant-based Medicinal Research
- Ion Transport and Channel Regulation
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- T-cell and B-cell Immunology
- Nutrition, Genetics, and Disease
- Synthesis and Biological Evaluation
- Free Radicals and Antioxidants
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Estrogen and related hormone effects
- Chemical Reactions and Isotopes
- PARP inhibition in cancer therapy
- Cancer Research and Treatments
- Effects of Radiation Exposure
- Digestive system and related health
- Glioma Diagnosis and Treatment
Sir Run Run Shaw Hospital
2024
Yale University
1996-2023
Abstract Tumor stroma plays a critical role in fostering tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) are major component of the stroma. Identifying key molecular determinants for pro-tumor properties CAFs could enable development more effective treatment strategies. Herein, through analyses single-cell sequencing data, we identified population expressing high levels sulfatase 1 (SULF1), which was associated with poor prognosis colorectal cancer (CRC) patients. CRC...
<div>Abstract<p>Tumor stroma plays a critical role in fostering tumor progression and metastasis. Cancer-associated fibroblasts (CAF) are major component of the stroma. Identifying key molecular determinants for protumor properties CAFs could enable development more effective treatment strategies. In this study, through analyses single-cell sequencing data, we identified population expressing high levels sulfatase 1 (<i>SULF1</i>), which was associated with poor...
We recently cloned a novel rabbit gene that encodes 725-amino acid protein (Kcn1) (Y. Yao, A. S. Segal, P. Welling, X. Zhang, C. M. McNicholas, D. Engel, E. L. Boulpaep, and G. Desir. Proc. Natl. Acad. Sci. USA 92: 11711-11715, 1995). Kcn1 RNA injected in Xenopus oocytes leads to the expression of potassium channels are specifically activated by guanosine 3',5'-cyclic monophosphate (cGMP). Northern blot ribonuclease (RNase) protection analysis show is differentially expressed kidney, aorta,...
<p>Supplementary Data.</p>
<p>Figure S9.</p>
<p>supplementary materials 1.</p>
<p>Figure S8.</p>
<p>supplementary materials 2.</p>
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<p>Figure S2.</p>
<p>Figure S3.</p>
<p>Figure S1.</p>