A5089930052- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Cultural and Sociopolitical Studies
- Epigenetics and DNA Methylation
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Fractures and Fixation Techniques
- Neurological disorders and treatments
- Neurosurgical Procedures and Complications
- Spinal Hematomas and Complications
- RNA modifications and cancer
- Fetal and Pediatric Neurological Disorders
- Cancer Cells and Metastasis
- Turkish Literature and Culture
- Parkinson's Disease Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Cancer-related Molecular Pathways
- Ottoman and Turkish Studies
- Teratomas and Epidermoid Cysts
- TGF-β signaling in diseases
- Mechanisms of cancer metastasis
- Neonatal and fetal brain pathology
- Cerebral Venous Sinus Thrombosis
- Medical Imaging and Analysis
- Linguistics and Cultural Studies
Fırat University
2015-2025
Icahn School of Medicine at Mount Sinai
2017-2023
Altınbaş University
2021
Boston University
2010-2020
Inonu University
2018
Antalya Eğitim ve Araştırma Hastanesi
2018
May Institute
2018
Creative Commons
2018
Konya Numune Hastanesi
2018
Neurology, Inc
2017
Abstract SMAD4 is localized to chromosome 18q21, a frequent site for loss of heterozygosity in advanced stage colon cancers. Although Smad4 regarded as signaling mediator the TGFβ pathway, its role major suppressor colorectal cancer progression and molecular events underlying this phenomenon remain elusive. Here, we describe establishment use cell line model systems dissect functional roles inactivation manifestation malignant phenotype. We found that function retention intact receptors...
Breast cancer progression is associated with aberrant DNA methylation and expression of genes that control the epithelial-mesenchymal transition (EMT), a critical step in malignant conversion. Although affected have been studied, there little understanding how activation machinery itself occurs. Using breast cell-based model system, we found cells underwent EMT exhibited overactive transforming growth factor beta (TGFbeta) signaling loss CDH1, CGN, CLDN4, KLK10 as result hypermethylation...
Abstract Metabolic changes induced by oncogenic drivers of cancer contribute to tumor growth and are attractive targets for treatment. Here, we found that increased PTEN-mutant cells was dependent on glutamine flux through the de novo pyrimidine synthesis pathway, which created sensitivity inhibition dihydroorotate dehydrogenase, a rate-limiting enzyme ring synthesis. S-phase showed numbers replication forks, inhibitors dehydrogenase led chromosome breaks cell death due inadequate ATR...
Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to restrain its metastatic potential urgently needed. In this study, we aimed identify novel genes that drive metastasis BLBC elucidate underlying mechanisms action.An unbiased approach using gene expression profiling a progression model in silico leveraging pre-existing tumor transcriptomes...
Metastatic dissemination of breast cancer cells represents a significant clinical obstacle to curative therapy. The loss function metastasis suppressor genes is major rate-limiting step in progression that prevents the formation new colonies at distal sites. However, discovery using genomic efforts has been slow, potentially due their primary regulation by epigenetic mechanisms. Here, we report use model cell lines with same genetic lineage for identification novel gene, serum deprivation...
TP53 is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in absence of acute cell stress, we found that wild-type but not mutant binds activates numerous genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, TNFRSF10B through consensus binding sites enhancers promoters. Depletion reduced expression these target analysis across 18 types showed associated with many genes. Regarding activated a luciferase reporter...
Tumors exhibit enhancer reprogramming compared to normal tissue. The etiology is largely attributed cell-intrinsic genomic alterations. Here, using freshly resected primary CRC tumors and patient-matched adjacent colon, we find divergent epigenetic landscapes between cell lines. Intriguingly, this phenomenon extends highly recurrent aberrant super-enhancers gained in over normal. We one such super-enhancer activated epithelial cancer cells due surrounding inflammation the tumor...
Basal-like breast cancer (BLBC) is an aggressive subtype of which often enriched with stem cells (CSC), but the underlying molecular basis for this connection remains elusive. We hypothesized that BLBC are able to establish a niche permissive maintenance CSCs and found tumor cell-derived periostin (POSTN), component extracellular matrix, as well corresponding cognate receptor, integrin α(v)β(3), highly expressed in subset cell lines CSC-enriched populations. Furthermore, we demonstrated...
Metastatic dissemination of cancer cells to distal organs is the major cause death for patients suffering from aggressive basal-like breast (BLBC) subtype. Recently, we have shown that interleukin 13 receptor alpha 2 (IL13Rα2) a critical gene overexpressed in subset BLBC primary tumors associated with poor distant metastasis-free survival (DMFS) and can promote extravasation metastasis lungs. However, upstream signaling mechanisms aberrant IL13Rα2 expression during tumor progression remain...
Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion intracellular signaling. Advances in understanding mammary epithelial hierarchy are converging with new developments that reveal how integrins regulate normal gland. But breast cancer, signaling contributes development progression tumors. This paper highlights recent studies examine role cells their malignant counterparts.
Triple-negative breast cancer (TNBC) is the most aggressive form of with poor prognosis due to lack druggable targets such as hormone and growth factor receptors. Therefore, identification targetable regulators miRNAs could provide new avenues for therapeutic applications. Here, we report that expression miR-4417 suppressed during progression TNBC cells from non-malignant malignant stage. MiR-4417 localized chromosome 1p36, a region high frequency loss heterozygosity in multiple cancers, its...
Beyin içerisinde hedeflenen noktaya güvenli bir şekilde ulaşmak önemli konudur. Trajeksiyon (giriş-hedef) boyunca kritik beyin yapılarına girilmemesi hedeflenir. Klasik planlamada yapıları (AC, PC, MC), giriş ve hedef noktaları cerrah tarafından manuel işaretlenir. Zaman alıcı yüksek risk barındıran bu sürecin bilgisayar destekli yazılımlarla desteklenmesine ihtiyaç duyulmaktadır. Bu alanda yapılan çalışmalar incelendiğinde, yapılarının (beyin, tümör, vasküler ağ) tespit edilerek haritasının...
Deciphering molecular targets to enhance sensitivity chemotherapy is becoming a priority for effectively treating cancers. Loss of function mutations
Our previous studies showed that the depletion of outer kinetochore protein hBub1 upon activation spindle assembly checkpoint (SAC) primarily triggers early cell death mediated by p53 rather than aneuploidy. Here, we report phosphorylation at Ser37 is critical for proapoptotic activity SAC activation. Furthermore, show physically interacts with kinetochores in response to mitotic damage suggesting a direct role suppression death. This observation further substantiated inhibition...
Aim of this paper is to recall the surgical technique used in recurrent lumbar disc herniations (LDHs) and share our experiences.Out series 1115 patients who underwent operations for LDH between 2006 2013, 70 re-operations, which were included study. During surgery, lateral decompression performed over medial facet joint superior border was seen after widening laminectomy defect, microdiscectomy performed. The demographic findings patients, their complaints admission hospital, level...
To show causes of dural tear in isolated lumbar disc surgery, and to investigate the risk factors.We retrospectively reviewed 1159 cases (532 females 627 males) involving patients who underwent a surgery for treatment herniation between 2006 2013. We have analysed side level operation, first or revision type anesthesia surgical procedure tear. examine differences levels, we used Chi-square testing categorical variables student's t test continuous variables. analyze our data, STATA version...
It has been universally believed that spindle assembly checkpoint (SAC) proteins which include the kinetochore are involved in monitoring faithful segregation of sister chromatids during cell division and hence defects these result anueploidy. Furthermore, there multiple sources experimental data to suggest a defect p53 could also promote genomic instability leading Despite observations, molecular basis for prevention aneuploidy maintain integrity upon activation SAC largely remained...
To investigate the possible role of ELABELA (ELA) in histopathological grading gliomas.We retrospectively assessed pathological specimens patients who underwent surgery for intracranial space-occupying lesions. Only primary glioma were included this study. We enrolled 11 histologically diagnosed with low-grade and 22 high-grade glioma. The ELA antibody was applied to 4?6-?m-thick sections obtained from paraffin blocks. Histoscores calculated using distribution intensity staining...
Inhibition of fatty acid synthase leads to apoptosis in cancers, which high levels synthesis. This indicates that cancer cells depend on order survive. In this study, we investigated whether or not there was a relationship between the glial tumor grade and free level tissue.Twenty patients who had tumors 20 low tumors, were included study. Tumors samples obtained intraoperatively measure levels. The acids studied three groups: saturated acids, monounsaturated polyunsaturated acids. They...