A5021258620- Alkaloids: synthesis and pharmacology
- Bioactive Compounds and Antitumor Agents
- Reproductive System and Pregnancy
- Bone Metabolism and Diseases
- Estrogen and related hormone effects
- DNA and Nucleic Acid Chemistry
- Phytochemistry and Bioactivity Studies
- Chemical synthesis and alkaloids
- Click Chemistry and Applications
University of Karachi
2018-2020
International Center for Chemical and Biological Sciences
2018-2020
Abstract Role of heterocyclic compounds with nitrogen substitution in therapeutic frontiers is well established. The efforts made this study are directed to dissect the biological significance benzimidazole‐substituted zinc phthalocyanine derivative. Its capacity act as an anticancer agent against 2 B‐lymphoma cell lines (low‐grade and high‐grade malignancy) was found out by recording florescence using Alamar blue dye. Further cytotoxic effect at DNA level analyzed performing agarose gel...
Biological significance of Amaryllidaceae is well advocated from the literature. In Cameroon, plants this family are routinely used for cure liver, cancer and cardiovascular diseases. To date, no scientific investigation corresponding to anti-cancer activity extracts isolated compounds Scadoxus pseudocaulus available.Current study focused elaborate anti-proliferative effects natural isolates (compounds 1-6, 9) hemi-synthetic analogs 7-8) extracted S. pseudocaulu.Column chromatography ethyl...
Background: Bone remodeling is a complex process that includes continuous resorption by osteoclast cells and bone formation osteoblast cells. fragility common health issue of the elderly population, particularly in postmenopausal women. It has been established steroidal hormones have an important role homeostasis. Therefore hormone replacement therapy could beneficial effects on as compared to other treatments. Objectives: An imbalance between rate leads bones. During current study, we aimed...