A5029470995- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Health, Medicine and Society
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Agriculture and Rural Development Research
- Cardiovascular and exercise physiology
- Maternal and Perinatal Health Interventions
- Global Maternal and Child Health
- High Altitude and Hypoxia
- Vitamin C and Antioxidants Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Maternal and fetal healthcare
- Aging, Elder Care, and Social Issues
- Healthcare Systems and Practices
- Biochemical Acid Research Studies
- Nutrition, Health, and Society Studies
- Peroxisome Proliferator-Activated Receptors
- Microbial Metabolism and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Selenium in Biological Systems
- Neuroscience of respiration and sleep
- Consumer Attitudes and Food Labeling
Université Côte d'Azur
2011-2024
Institut de Biologie Valrose
2024
Inserm
2006-2023
Centre National de la Recherche Scientifique
2022-2023
Laboratoire Motricité Humaine Éducation Sport Santé
2022
Centre Méditerranéen de Médecine Moléculaire
2014-2021
Université de Versailles Saint-Quentin-en-Yvelines
2018-2019
Université Joseph Fourier
2004-2005
Mitochondrie, stress oxydant et protection musculaire
2003
The use of two non-consecutive 24 h recalls using EPIC-Soft for standardised dietary monitoring in European countries has previously been proposed the Food Consumption Survey Method consortium. Whether this methodology is sufficiently valid to assess nutrient intake a comparable way, among populations with different food patterns Europe, subject study Validation objective was compare validity usual protein and K estimated from between five selected centres Europe. A total 600 adults, aged...
Objective and Methods: The present controlled-training, double-blind study (supplemented, n = 7; placebo, 9) investigated whether taper training (TT) antioxidant supplementation, i.e., 150 μg of selenium, 2000 IU retinol, 120 mg ascorbic acid 30 α-tocopherol, modulates potential, redox status oxidative damage occurrence both at rest in response to exercise. Two weeks TT followed four overloaded training. Dietary intakes were recorded. Before after TT, triathletes did a duathlon consisting...
The present controlled-training double-blind study (supplemented (S) group, n 7; placebo (P) 10) was designed to investigate whether an antioxidant mixture (Se 150 μg, retinyl acetate mg, ascorbic acid 120 α-tocopheryl succinate) would allow overloaded triathletes avoid adaptation failure in the system. Dietary intakes were recorded. supplement of Se, and vitamins A E provided 100 % French RDA. Four weeks training (OT) followed 4 normal (NT). After NT OT, biological studies conducted at rest...
We conducted a cross-sectional study in 118 well-trained athletes to investigate 'high exposure' sub-deficient antioxidant status, and consequently oxidative damage, relation estimated daily energy expenditure (EE) dietary intake. Subjects completed 7 d food activity records. Blood samples were obtained on day 8. Of the 81, 60 43 % had intakes of vitamins E, C β-carotene below two-thirds French RDA respectively, which is adjusted for EE (FRDAa). The deficit vitamin E intake was positively...
Metabolism plays an important role in T cell biology and changes metabolism drive differentiation fate. Most research on the of lymphocytes focuses mature cells while only few studies have investigated development. In this study, we report that activation or overexpression transcription factor Peroxisome Proliferator-Activated Receptor β (PPARβ) increases fatty acid oxidation cells. Furthermore, using both vivo vitro models, demonstrate PPARβ activation/overexpression inhibits thymic...
The risk of oxidative stress-related metabolic diseases increases with menopause and physical inactivity. We hypothesized that an 8-week Tai Chi (TC) training program (2 sessions in class; 2 at home; 1-1:15/session) would improve antioxidant capacity reduce cardiovascular risks both pre- (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>8</mml:mn></mml:mrow></mml:math>) postmenopausal...
We hypothesized that α-lipoic acid (α-LA) might interact with the transcriptional control of peroxisome proliferator-activated receptor (PPAR)b in skeletal muscle. Molecular mechanisms were investigated using differentiated C2C12 myotubes treated α-LA and/or PPARβ agonist GW0742. In vivo studies 3-mo-old C57Bl6 mice realized: voluntary wheel running (VWR) training (7 wk), and a 6 wk diet containing (or not) (0.25% wt/wt). This last condition was combined 1 bout treadmill exercise (18 m/min...
Abstract Selenium requirements in athletes are supposed to be increased with energy expenditure (EE) preserve selenium status and an optimal antioxidant balance. The question of whether intakes related EE plasma induces up‐regulation erythrocyte endogenous defense decreases oxidative damage markers was addressed. 118 well‐trained completed 7 d food activities records a cross‐sectional study. Blood sampled on day 8. Among the athletes, 23% males 66% females had below two‐third French RDA....
Abstract The decrease in the regulatory T cells (Tregs) population is highly involved adipose tissue inflammation and insulin resistance obesity. Tregs depend on fatty acids via β‐oxidation for immunosuppressive function adapting their antioxidant systems to allow survival oxidative stress. In this study, we have hypothesized that a dietary supplementation with alpha‐lipoic acid (ALA), powerful antioxidant, would improve immunometabolism when added classical strategy of obesity treatment....
Regular aerobic exercise, independently of weight loss, improves metabolic and anti-inflammatory states, can be regarded as beneficial in counteracting obesity-induced low-grade inflammation. However, it is still unknown how exercise alters immunometabolism a context dietary changes. Agonists the Peroxisome Proliferator Activated-Receptor beta/delta (PPARβ/δ) have been studied this last decade "exercise-mimetics", which are potential therapies for diseases. In study, we address question...
De la distinction entre les vieillissements sain et pathologique est née capacité de vitalité. Sous-tendant le plan physiologique du vieillissement, elle se reflète dans fonction neuromusculaire, réponse immunitaire au stress, métabolisme. La neuromusculaire permet à l'activité physique d'être. L'activité influence, en ses modalités, autres composantes Les trois dimensions semblent dégrader avec l'âge, sauf chez individus ayant maintenu une activité tout long leur vie. Alors, orientés par...
The implication of αβ and γδ T cells in obesity-associated inflammation insulin resistance (IR) remains uncertain. Mice lacking show either no difference or a decrease high-fat diet (HFD)-induced IR, whereas partial depletion does not protect from HFD-induced IR. T-cell deficiency leads to white adipose tissue (WAT) IR without weight change, but these has been studied. We previously described mouse model overexpressing peroxisome proliferator-activated receptor β (PPAR-β) specifically...
Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4 + by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate secondary lymphoid organs involved impairment of skeletal muscle (SKM) regeneration mass maintenance. In this study, we showed that a deletion FAO modulator, peroxisome proliferator-activated receptor beta/delta (PPARβ/δ), specifically (KO-T PPARβ/δ), increased number at day 2...
Haemoglobin E (HbE), an unstable haemoglobin, is highly susceptible to oxidative damages. We examined how acute or chronic physiological challenge induced by exercise affects antioxidant response in HbE carriers. Two independent studies were conducted individuals with trait and paired normal Hb. In study 1, sedentary participants tested a graded maximal blood samples collected before, immediately after, 45 minutes after exercise. Our data showed that erythrocyte glutathione peroxidase (GPx)...
Synthetic ligands of peroxisome-proliferator-activated receptor beta/delta (PPARβ/δ) are being used as performance-enhancing drugs by athletes. Since we previously showed that PPARβ/δ activation affects T cell biology, wanted to investigate whether a specific blood signature could be employed method detect the use agonists. We analyzed in primary human cells vitro effect on fatty acid oxidation (FAO) and their differentiation into regulatory (Tregs). Furthermore, conducted studies mice...