A5021138452- Zebrafish Biomedical Research Applications
- Aquaculture disease management and microbiota
- Reproductive System and Pregnancy
- Aquaculture Nutrition and Growth
- Reproductive biology and impacts on aquatic species
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Identification and Quantification in Food
- Liver Disease Diagnosis and Treatment
- Fish Ecology and Management Studies
- Liver Disease and Transplantation
- Ichthyology and Marine Biology
- Immune responses and vaccinations
- Physiological and biochemical adaptations
- Erythrocyte Function and Pathophysiology
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Isotope Analysis in Ecology
- Aquatic Invertebrate Ecology and Behavior
- Genetics, Aging, and Longevity in Model Organisms
- Fatty Acid Research and Health
- Orthopedic Infections and Treatments
- Hemoglobinopathies and Related Disorders
- Phagocytosis and Immune Regulation
Southwest University
2019-2024
Affiliated Hospital of Guizhou Medical University
2020-2023
Guizhou University
2023
Hepatic steatosis caused by starvation, resulting in non-alcoholic fatty liver disease (NAFLD), has been a research topic of human clinical and animal experiments. To understand the molecular mechanisms underlying triggering abnormal metabolism thus inducing hepatic lipid accumulation, we used zebrafish larvae to establish starvation-induced model conducted comparative transcriptome analysis RNA-seq. We demonstrated that incidence is positively correlated with starvation time. Under...
Abstract High-dose perfluorooctanoic acid (PFOA) impairs oocyte maturation and offspring quality. However, the physiological concentrations of PFOA in follicular fluids patients with premature ovarian insufficiency (POI) were detected at lower levels, thus relationship between reproductive disorders remains elusive. Here, we investigated whether exposure affects gonad function adult zebrafish. Physiological resulted POI-like phenotypes females, which exhibited decreased spawning frequency,...
Oxidation resistance gene 1 (OXR1) is essential for protection against oxidative stress in mammals, but its functions non-mammalian vertebrates, especially fish, remain uncertain. Here, we created a homozygous oxr1a-knockout zebrafish via the CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9) system. Compared with wild-type (WT) zebrafish, oxr1a-/- mutants exhibited higher mortality and more apoptotic cells under stress, multiple antioxidant...
Abstract We conducted a comprehensive analysis to evaluate the benefits of negative pressure wound therapy (NPWT) versus traditional dressings in preventing surgical site infections patients undergoing cardiac surgery. thoroughly examined several databases, including PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, Chinese Biomedical Literature Database (CBM) and Wanfang, from inception until July 2023. Two independent researchers were responsible for...
To investigate the effects of different raising environments on flesh quality, study set up three groups silver carp (Hypophthalmichthys molitrix), that is, pond-farmed; short-term stocked; and ranched, grown in a natural water ranch. This compared differences muscle proximate composition amino acid among groups. The results showed there was no difference between ranched stocked content crude protein, ash, total acids (TAA), essential (EAA), umami-flavored (UAA), with both being...
Temperature variation affects the growth performance of fish species due to growing constraints and trade-off on physiological functions. Here we experimentally investigated several metabolic parameters in Sinilabeo rendahli , an endemic found Yangtze River China. After a 14-day acclimation period, measured routine rate (RMR), individual ( MO 2 ), temperature quotient (Q 10 loss equilibrium (LOE), critical oxygen tension P crit ) at three different temperatures (15, 20, 25°C). Moreover,...
The liver is essential for nutritional balance in fish, and damage farmed fish often arises from factors like overfeeding, causing various health issues. Clinical observations indicate that diseases frequently involve spleen dysfunction, there evidence to suggest the has a significant impact on function. However, been no discussion role of maintaining fish. To understand metabolism, this study selected Nile tilapia ( Oreochromis niloticus ) as experimental material first established...
Splenectomy or congenital asplenia in humans increases susceptibility to infections. We have previously reported that zebrafish reduces resistance Aeromonas hydrophila infection. However, the molecular mechanism of systemic immune response congenitally asplenic individuals is largely unexplored. In this study, we found pro-inflammatory cytokines were more highly induced than wild-type after pathogenic A. infection and lipopolysaccharide exposure. addition, a higher aggregation apoptotic...
Background/Aims: Nasopharyngeal carcinoma is a common head and neck cancer in South China Southeast Asia. Radiotherapy the standard treatment for nasopharyngeal carcinoma. Accumulating evidence showed that expression of miR-34a was abnormal Here, this study investigates effect on radiosensitivity cells explored underlying mechanisms. Methods: Reverse transcription quantitative polymerase chain reaction used to analyze cell lines NP69 cells. The (CNE-1 cells) evaluated by Cell Counting Kit-8,...
Food chain length (FCL) is a critical measure of food web complexity that influences the community structure and ecosystem function. The FCL large subtropical rivers affected by dams decisive factors are far beyond clear. In this study, we used stable isotope technology to estimate fish in different reaches main stream Yangtze River explored key determined FCL. results showed varied widely among studied areas with mean 4.09 (ranging from 3.69 4.31). variation river sections upstream dam was...
The Yangtze grenadier anchovy, Coilia brachygnathus, is a commercial fishery species in the middle and lower River of China. Here, we describe complete mitochondrial genome from newly found population C. brachygnahus upper River. It was 16,857 bp size encodes for 2 rRNAs, 22 tRNAs, 13 protein-coding genes as well D-loop control region. Phylogenetic analysis confirmed evolutionary relationship brachygnathus to other five genus Coillia. would help elucidate origin new brachygnathus.
The Odontobutis potamophila is endemic commercial fishery species to China and distributed mainly in middle lower Yangtze River of China. Here, we describe a complete mitochondrial genome from the newly found population O. Three Gorges Reservoir where located upper River. It was 16,939 bp size encodes for two rRNAs, 22 tRNAs, 13 protein-coding genes, D-loop control region. Phylogenetic analysis confirmed evolutionary relationship other five genus Odontobutis. would help elucidate origin new...