A5101973261- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Fluoride Effects and Removal
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Phytochemical Studies and Bioactivities
- Mercury impact and mitigation studies
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Phytochemistry and Bioactive Compounds
- Microbial Inactivation Methods
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Osteoarthritis Treatment and Mechanisms
- NF-κB Signaling Pathways
- Advancements in Semiconductor Devices and Circuit Design
- Chromatin Remodeling and Cancer
- Solidification and crystal growth phenomena
- Eosinophilic Disorders and Syndromes
- Cancer Mechanisms and Therapy
- COVID-19 and healthcare impacts
- Botanical Studies and Applications
- Porphyrin Metabolism and Disorders
Guiyang Medical University
2018-2025
Affiliated Hospital of Guizhou Medical University
2018-2025
Yan'an University
2025
Yanan University Affiliated Hospital
2025
Renmin University of China
2022
Jilin University
2020
Fujian Medical University
2015
Guangxi University
2015
Jiamusi University
2014
Tianjin University
2006-2012
Anti-CD19 chimeric antigen receptor (CAR) T cell therapy is a common, yet highly efficient, cellular immunotherapy for lymphoma. However, many recent studies have reported on its cardiovascular (CV) toxicity. This study analyzes the cardiotoxicity of CD19 CAR in treatment lymphoma providing more valuable reference clinicians. The PubMed, Embase, Cochrane library, and Web Science databases were comprehensively searched from time their establishment to May 2024. ClinicalTrials.gov English...
Abstract This study aimed to evaluate the efficacy and safety of venetoclax plus azacitidine donor lymphocyte infusion (DLI) in treating patients with relapsed acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twenty-six AML who allo-HSCT were enrolled treated DLI. Complete remission incomplete recovery (CRi), partial (PR), objective rate (ORR) assessed, then event-free survival (EFS) overall (OS) evaluated. Besides, adverse events documented....
Fluoride is considered an environmental pollutant that seriously affects organisms and ecosystems, its harmfulness a perpetual public health concern. The toxic effects of fluoride include organelle damage, oxidative stress, cell cycle destruction, inflammatory factor secretion, apoptosis induction, synaptic nerve transmission destruction. To reveal the mechanism fluorosis-induced brain we analyzed molecular learning memory function SIRT1-mediated BDNF-TrkB signaling pathway cascade reaction...
Abstract Background Colorectal adenocarcinoma (CRA) is one of the leading causes cancer-related deaths in world. Long non-coding RNAs (lncRNAs) have been implicated to be effective regulators disease course human cancers, including CRA. Small nucleolar RNA host gene 17 (SNHG17) belongs lncRNAs, and it has reported breast cancer gastric cancer. However, function SNHG17 its mechanism CRA progression remain largely unknown. In this study, we attended shedding some light on role Methods RT-qPCR...
The therapeutic benefits of mesenchymal stromal cells (MSCs) are largely dependent on paracrine factors, but the supernatants different MSCs may have effects multiple myeloma (MM) cells. Therefore, this study compared bone marrow-derived (BM-MSCs) with umbilical cord wharton's jelly's stem (UC-WJ MSCs) in states (non-senescent and replicative senescence) MM We extracted human BM-MSCs UC-WJ vitro used H2O2 to induce senescence. Concentrated from senescent (SMSCs) were added Cell...
Body composition has been associated with various health outcomes, but its specific relationship arthritis risk remains unclear. The study aimed to examine the associations between lean body mass (LBM) and fat (FM) in men women identify their threshold values. data were obtained from CHARLS, a prospective cohort 2011 2018. Multivariate Cox regression models evaluated LBM FM risk. Smoothing curves two-piece linear applied inflection points of A total 6,761 participants included this study....
This study assessed the efficacy of proteasome inhibitors (PIs) in both maintenance and consolidation therapies for MM patients. A comprehensive search across multiple databases was conducted, including PubMed, Science Direct, Google Scholar, CNKI, EMBASE, Web Science, MEDLINE, Cochrane Library, others, to identify randomized controlled trials published Chinese English languages that examined use PIs either or therapy myeloma. The effectiveness outcomes included complete response (CR), very...
Ultrasound (US) has gained popularity in the evaluation of haemophilic joint diseases because it enables imaging soft-tissue lesions joints and bone-cartilage lesions. We aimed to determine correlation between US evaluations clinical assessments performed using HJHS 2.1 evaluate their respective characteristics assessing early arthropathy. A total 178 (32 knees, 85 elbows, 61 ankles) 45 haemophilia patients (median age, 10 years; range, 6-15) were assessed 2.1. Ultrasonographic scoring was...
Abstract Despite advancements in chemotherapy and the availability of novel therapies, outcome adult patients with B-cell acute lymphoblastic leukemia (B-ALL) remains unsatisfactory. Therefore, it is necessary to understand molecular mechanisms underlying progression B-ALL. Brahma-related gene 1 (BRG1) a poor prognostic factor for multiple cancers. Here, expression BRG1 was found be higher B-ALL, irrespective subtype, than healthy individuals, its overexpression associated prognosis....
Introduction: Asparagus (Asparagus officinalis) is a perennial flowering plant species. Its main components have tumor-prevention, immune system-enhancement, and anti-inflammation effects. Network pharmacology powerful approach that being applied increasingly to research of herbal medicines. Herb identification, study compound targets, network construction, analysis been used elucidate how medicines work. However, the interaction bioactive substances from asparagus with targets involved in...
Objective: This study mainly determined the effect of beta-amyloid peptides (Abeta1–42) on ATP-sensitive potassium (KATP) channels cultured cortical and hippocampal cholinergic neurons, further confirmed protective Diazoxide, which was specific opener KATP channels, to neurons.Methods: The primary rat neurons were cultured. Membrane currents measured using whole-cell patch-clamp technique.Results: data showed that outward current significantly decreased after Abeta1–42 (P<0·05), did not...
Abstract Background The combination of rituximab and chemotherapy is a first-line treatment for patients with B-cell non-Hodgkin lymphoma. Lenalidomide an immunomodulatory drug that has shown promising properties activity in variety hematological malignancies. This study evaluated the efficacy safety lenalidomide-based regimens Methods PubMed, Science Direct, ClinicalTrials.gov, Web databases were searched relevant studies published up to May 2022. Studies diagnosed lymphoma, who randomly...
ABSTRACT Asparagus officinalis (ASP) has antioxidation, anti‐inflammatory, antiaging, and immune system‐enhancing effects. We explored the preventive therapeutic consequences of ASP on brain damage elicited by fluorosis through network pharmacology in vivo experimental validation. ascertained pharmaceutically active ingredients drug targets from Traditional Chinese Medicine Systems Pharmacology database, predicted disease fluorosis‐induced injury using GeneCards Online Mendelian Inheritance...
Asparagus (ASP) is a well-known traditional Chinese medicine with nourishing, moistening, fire-clearing, cough-suppressing, and intestinal effects. In addition, it exerts anti-inflammatory, antioxidant, anti-aging, immunity-enhancing, anti-tumor pharmacological effect. The effect of ASP has been studied in hepatocellular carcinoma. However, its action mechanism colorectal cancer (CRC) are unclear. present study aimed to identify the potential targets for CRC treatment using network...
Background/Aims: Nasopharyngeal carcinoma is a common head and neck cancer in South China Southeast Asia. Radiotherapy the standard treatment for nasopharyngeal carcinoma. Accumulating evidence showed that expression of miR-34a was abnormal Here, this study investigates effect on radiosensitivity cells explored underlying mechanisms. Methods: Reverse transcription quantitative polymerase chain reaction used to analyze cell lines NP69 cells. The (CNE-1 cells) evaluated by Cell Counting Kit-8,...