A5100762792- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Studies
- Cancer-related molecular mechanisms research
- Neuroendocrine regulation and behavior
- Viral-associated cancers and disorders
- Neuroscience and Neuropharmacology Research
- Cancer Mechanisms and Therapy
- Phytochemicals and Antioxidant Activities
- Medical Research and Treatments
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Tea Polyphenols and Effects
- Immune cells in cancer
- Metabolomics and Mass Spectrometry Studies
- Molecular Sensors and Ion Detection
- Stress Responses and Cortisol
- Advanced Nanomaterials in Catalysis
- Healthcare and Venom Research
- Melamine detection and toxicity
- Phytochemical compounds biological activities
- Fluoride Effects and Removal
- Bladder and Urothelial Cancer Treatments
Affiliated Hospital of Guizhou Medical University
2019-2025
Guizhou University
2019-2025
Chronic fluorosis is often accompanied by neurological symptoms, leading to attention, memory and learning ability decline causing tension, anxiety, depression, other mental symptoms. In the present study, we analyzed molecular mechanisms of SIRT1-BDNF regulation PI3K-AKT, MAPK, FOXO1A in F-treated BV2 cells. The cytotoxic effect sodium fluoride (NaF) on cells was assessed using Cell Counting Kit-8 (CCK-8), crystal violet, 5-ethynyl-2'-deoxyuridine (EdU) staining. cycle progression apoptosis...
Camellia oleifera is a medicine food homology plant widely cultivated in the Yangtze River Basin and southern China due to its camellia oil. bud fruit exist simultaneously, largely discarded as waste. However, C. has been used traditional Chinese treat variety of ailments. Thus, purpose this study was identify chemical components ethanol extract (EE) first evaluate anticancer effects non-small cell lung cancer A549 cells. Based on UHPLC-Q-Orbitrap-MS analysis, seventy were identified. For...
Mature brain-derived neurotrophic factor (BDNF) and its downstream signaling pathways have been implicated in regulating postnatal development functioning of rodent brain. However, the biological role precursor pro-brain-derived (proBDNF) brain remains unknown. The expression hippocampal proBDNF was blocked weeks, multiple behavioral tests, Western blot morphological techniques, neural recordings were employed to investigate how played a spatial cognition adults. peak crucial effects found...
Abstract Studies suggest a possible association between Epstein-Barr virus (EBV) infection and bladder cancer (BCa) risk, though this remains unclear. Secreted frizzled-related protein (sFRP) is also linked to BCa, with some DNA viruses potentially regulating its expression. This study used Mendelian randomization (MR) colocalization analysis explore the causal relationship EBV infection, BCa mediating role of sFRP. We first performed two-sample MR assess 5 EBV-related antibodies (AEB-IgG,...
This study seeks to investigate the key research hotspots and evolving trends in chemotherapy-induced bone marrow suppression over past two decades by employing bibliometric visualization analysis, thereby providing a robust theoretical empirical foundation for advancements both scientific understanding clinical practice. Utilizing Web of Science Core Database, total 6,110 documents were retrieved analyzed using CiteSpace VOSviewer software. analysis traces evaluates current status,...
Gehua Jiecheng Decoction (GHJCD), a famous traditional Chinese medicine, has been used in the prevention and treatment of precancerous lesion liver cancer, but its active mechanism not reported. This study aimed to evaluate therapeutic effect GHJCD on diethylnitrosamine-induced hepatocellular carcinoma (HCC) mice this effect. We found that effectively inhibited occurrence cancer reduced tumor area. The ratio regulatory cells (Tregs), associated macrophage(TAMs), myeloid-derived suppressor...
Lung adenocarcinoma associated transcript 1 (LUADT1) has been reported as an oncogenic long non-coding RNA (lncRNA) in lung adenocarcinoma, while its roles small cell cancer (SCLC) are unknown. Our interaction bioinformatics prediction showed that LUADT1 could form strong base pairing with miR-15a-3p, which is a tumor-suppressive miRNA can target Twist1. We found and Twist1 were upregulated SCLC, miR-15a-3p was downregulated SCLC. However, posively correlated but not significnatly...
Although melamine exposure induces cognitive deficits and dysfunctional neurotransmission in hippocampal Cornus Ammonis (CA) 1 region of rats, it is unclear whether the neural function, such as oscillations between CA3–CA1 pathway postsynaptic receptors involves these effects. The levels alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit glutamate (GluR) GluR2/3 CA1 melamine-treated which were intragastric treated with 300 mg/kg/day for 4 weeks, detected....
BACKGROUND:Successful chemotherapy of lung cancer relies largely on the use a good drug delivery system (DDS). We successfully constructed hybrid DDS comprised hydroxyapatite (HAP) nanoparticles and bovine serum albumin (BSA). MATERIAL AND METHODS:The HAP were selected as core to encapsulate anticancer doxorubicin (DOX), followed by surface modification BSA stabilizer shielding corona finally prepare (BSA/HAP/DOX). RESULTS:The following characterizations revealed that BSA/HAP have high...
Background: Establishing the causal links between biomarkers and cancer enhances understanding of risk factors facilitates discovery therapeutic targets.To this end, we used Mendelian randomization (MR) colocalization analysis to explore relationship blood urinary (BUBs) with urological cancers (UCs).Methods: First, a two-sample MR study 33 BUBs 4 UCs, while performed reverse randomization.After Bonferroni correction, for BUB UC significant causality confirmed direct by multivariate...
Colon adenocarcinoma (COAD) is a common malignant tumor of the digestive tract that threatens human health seriously. Thus, it urgent to explore biomarkers can be used evaluate patient's survival prognosis overall as supplementary treatment. RNA-seq expression profiles were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus, Lasso multivariate Cox regression analyses for developing prognostic model. Finally, nomogram comprising model was established overall. A risk comprised...
Abstract Background Numerous studies have shown that cell cycle-associated protein B1 (Cyclin B1, CCNB1) is overexpressed in many cancers and involved cancer growth, differentiation, apoptosis, metastasis. However, the biological functions molecular mechanisms of CCNB1 colorectal (CRC) still remain unclear. Methods Herein, HPA database UCSC genomic were used to analyze mRNA expression levels different tissues humans or vertebrates. The TIMER was evaluate various tissue samples adjacent...
Background The high heterogeneity of Hepatocellular carcinoma (HCC) has led to poor clinical outcomes. critical role amino acid metabolic reprogramming in tumor growth is gradually emerging. However, metabolism HCC less studied, and the mechanisms still need be clarified. Methods We acquired transcriptome information on patients from public databases. Amino metabolism-related genes (ACRGs) were used as prognostic markers. built prognosis-related ACRG_score model using Univariate/Multivariate...
Abstract Background The hepatocellular carcinoma (HCC) is a malignant tumor of the hepatic domain that one most prevalent malignancies digestive system worldwide. Hepatocellular carcinoma, ferroptosis, and autophagy are closely related. understanding these relationships enables researchers to uncover pathogenesis liver cancer develop new treatment strategies. Methods Four genes related prognosis LIHC were screened, risk score model was established. classifies HCC patients from different...