A5100430317- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- Extracellular vesicles in disease
- RNA Research and Splicing
- Adipokines, Inflammation, and Metabolic Diseases
- interferon and immune responses
- Radiomics and Machine Learning in Medical Imaging
- Cell death mechanisms and regulation
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- RNA regulation and disease
- Cardiac Ischemia and Reperfusion
- Ocular Diseases and Behçet’s Syndrome
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- FOXO transcription factor regulation
Örebro University
2023
Jilin University
2018-2022
Union Hospital
2018-2022
Taian City Central Hospital
2022
China Medical University
2009-2021
First People's Hospital of Yunnan Province
2016-2019
National Medical Products Administration
2018
Gansu Provincial Hospital
2018
University of Massachusetts Chan Medical School
2016-2017
Harbin Medical University
2016
Abstract MicroRNAs (miRNAs) have been reported to be involved in DNA damage response induced by ionizing radiation (IR). c-Myc is reduced when cells treated with IR or other damaging agents. It unknown whether miRNAs participate downregulation IR. In the present study, we found that miR-449a enhanced radiosensitivity vitro and vivo targeting prostate cancer (LNCaP) cells. MiR-449a was upregulated downregulated LNCaP Overexpression of knockdown promoted sensitivity By establishing as a direct...
miR-126 has recently been implicated in modulating angiogenic factors vascular development. Understandings its biological significance might enable development of therapeutic interventions for diseases like age-related macular degeneration (AMD). We aimed to determine the role AMD using a laser-induced choroidal neovascularization (CNV) mouse model. CNV was induced by laser photocoagulation C57BL/6 mice. The mice were transfected with scrambled miR or mimic. expression miR-126, endothelial...
Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response hyperlipidemia and may be suitable therapeutic targets combat atherosclerosis.
Abstract Recent studies have identified microRNAs (miRNAs) as a compelling novel class of biomarker in colorectal cancer (CRC) development and metastasis. Here, we demonstrated that the level plasma exosomal miR‐140‐3p CRC patients was lower than healthy controls. The decreased also observed with liver expression tissues were significantly matched normal tissues. Functionally, overexpression suppressed proliferation, migration, invasion, β‐catenin nuclear translocation, well promoted...
Dicer is aberrantly expressed in several types of cancers. Applying real-time PCR, we detected the expression mRNA normal mucosa (n = 162), primary colorectal cancer (CRC) 162) and liver metastasis 37), analysed relationship between clinicopathological features. We also correlated to miRNA miR-141, miR-200a, miR-200b, mir-200c miR-429 metastases.RT-PCR qPCR were used analyse mucosa, tumour by using High Capacity cDNA Reverse Transcription Kit TaqMan™® Gene Expression assays for GAPDH. RT-PCR...
Altered expression of miRNA-98 (miR-98) has been reported in osteoarthritis (OA) patients, while its role and underlying mechanisms remain elusive. In the present study, a rat model OA was established using modified Hulth method, level miR-98 effect on cartilage degradation cell apoptosis rats were examined. The results showed that up-regulated observed rats, knockdown resulted an inhibitory chondrocyte apoptosis. Then potential associated genes regulated by screened examined tissues. target...
Aim of the Study: To investigate role microRNA-221 (miR-221) in airway epithelial cell injury asthma and delineate underlying mechanism that may involve with SIRT1. Materials Method: Bronchial cells from patients healthy controls were obtained by bronchoscopic brushing. The miR-221 SIRT1 mRNA level collected detected qRT-CPR. BEAS2B lines cultured vitro. In order to up-regulate SIRT1, mimic pcDNA3.1-SIRT1 vector was transfected into cells, respectively. expression changes after transfection...
Purpose: This study aimed to investigate the effects of microRNA (miR)-22 on biological behaviors colon cancer cells and explore relationship between miR-22 NLRP3. Materials Methods: First, human HCT116 were transfected with a mimic, inhibitor, control respectively. CCK8, colony formation, transwell assays performed observe cell proliferation, migration, invasion. Western blotting was used analyze expression recombinant NLRP3 (NLR family, pyrin domain-containing protein 3)...
Extensive epidemiological data have demonstrated an exponential rise in the incidence of non-Hodgkin lymphoma (NHL) that is associated with increasing age. The molecular etiology this remains largely unknown, which impacts effectiveness treatment for patients. We proposed age-dependent circulating microRNA (miRNA) signatures host influence diffuse large B cell (DLBCL) development. Our objective was to examine tumor development age-based DLBCL system using inventive systems biology approach....
Radiotherapy is a standard adjuvant therapy in patients with progressive rectal cancer, but many are resistant to radiotherapy, leading poor prognosis. Our study identified microRNA-652 (miR-652) value on radiotherapy response and outcome cancer patients.miR-652 expression was determined by qPCR primary from 48 53 without radiotherapy. The association of miR-652 biological factors the prognosis examined. function through TCGA GEPIA database searches. Two human colon cell lines (HCT116 p53+/+...
The obesity hormone, leptin, has been found to participate in the development and proliferation of normal malignant tissues. aim this study was evaluate role leptin human colorectal cancer. Serum levels were measured via ABC-ELLSA 30 cancers 24 controls. Leptin concentration cancer analyzed terms selected clinicopathological features some oncogenes. mean significantly higher for cancers(3.54±1.46 ng/ml) than controls(2.27±0.99 ng/ml), no gender difference observed study. expression poorly...
Abstract miR-30c functions as a tumor suppressor gene in the majority of tumors, including gliomas. In our study, we discovered that expression levels glioma tissues and plasma prior to surgery were lower than those normal brain tissue following injury decompression healthy volunteers. The low was closely aligned with WHO grade, size, PFS, OS. Additionally, level positively correlated preoperative plasma. cell biology experiments, inhibited EMT proliferation, migration, invasion cells....