A5072966421- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Antibiotic Resistance in Bacteria
- Cardiac electrophysiology and arrhythmias
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Pharmaceutical studies and practices
- Antifungal resistance and susceptibility
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Pesticide Residue Analysis and Safety
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Drug-Induced Adverse Reactions
- Pharmacy and Medical Practices
- Renal Transplantation Outcomes and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Ion channel regulation and function
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects of Natural Compounds
- Liver Disease and Transplantation
- Pregnancy and Medication Impact
- Analytical Methods in Pharmaceuticals
Nihon University
2019-2025
Matsudo City Hospital
2014-2023
Pharmac
2021-2022
University of Toyama
2013-2019
Kyushu University
2015-2018
Graduate School USA
2018
University of Auckland
2017
Osaka University
1986-2016
Sasebo City General Hospital
2007-2012
Waseda University
2011
ABSTRACT Autophagy is an intracellular degradation pathway conserved in eukaryotes. Among core autophagy-related (Atg) proteins, mammalian Atg9A the sole multi-spanning transmembrane protein, and both of its N- C-terminal domains are exposed to cytoplasm. It known that travels through trans-Golgi network (TGN) endosomal system under nutrient-rich conditions, transiently localizes autophagosome upon autophagy induction. However, significance trafficking for formation remains elusive. Here, we...
Aims Thrombocytopenia is among the most important adverse effects of linezolid treatment. Linezolid‐induced thrombocytopenia incidence varies considerably but has been associated with impaired renal function. We investigated pharmacodynamic mechanism (myelosuppression or enhanced platelet destruction) and role function (RF) in development thrombocytopenia. Methods The pharmacokinetics were described a two‐compartment distribution model first‐order absorption elimination. RF was calculated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopic evidence for the generation of singlet oxygen in self-reaction sec-peroxy radicalsMinoru Nakano, Kiyoshige Takayama, Yoshiaki Shimizu, Yasuhiro Tsuji, Humio Inaba, and Toshihiko MigitaCite this: J. Am. Chem. Soc. 1976, 98, 7, 1974–1975Publication Date (Print):March 1, 1976Publication History Published online1 May 2002Published inissue 1 March...
We developed a method to apply artificial neural networks (ANNs) for predicting time-series pharmacokinetics (PKs), and an interpretable the ANN-PK model, which can explain evidence of prediction by applying Shapley additive explanations (SHAP). A previous population PK (PopPK) model cyclosporin was used as comparison model. The patients' data were input, output ANN clearance (CL). estimated CL value from substituted into one-compartment with one-order absorption concentrations calculated,...
Abstract— The systematic study of the method for measuring spectral distribution extra‐weak light signals, such as from biochemical systems and living tissues involving chemi‐ bio‐energized processes, led to design construction a new type spectrometer, called filter analyzer system, incorporated with high‐sensitivity photon counting technique. Experimental tests examine operational characteristics this system comparisons signal‐to‐noise ratio conventional grating spectrometer were made by...
Methotrexate (MTX) is the most important drug for treating rheumatoid arthritis (RA). It has been stated that cytokines play an role in pathogenesis of RA, and cytokine levels increase show 24-h rhythms RA patients. Previously, we found was relieved after administration MTX at specific times synchronization with rhythm tumor necrosis factor (TNF)-α collagen-induced (CIA) animals. Based on our findings earlier study dosing time-dependent effects MRL/lpr mice, which develop autoimmune...
Yoichi Hiraki*a, Yasuhiro Tsujib, Mikako Hiraikea, Nobuhiro Misumia, Kana Matsumotoc, Kunihiko Moritac, Hidetoshi Kamimurad & Yoshiharu Karubeda Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto, Kumamotob Sasebo Chuo Hospital, Sasebo, Nagasakic Clinical Pharmaceutics, Faculty Pharmaceutical Sciences, Doshisha Women's College Liberal Arts, Kodo, Kyotanabe, Kyotod Fukuoka University, Johnan-ku, Fukuoka, Japan
Abstract Background Linezolid is administered as a fixed dose to all patients despite evidence of overexposure and thrombocytopenia in renal impairment. The aims this study were evaluate the risk utility therapeutic drug monitoring (TDM), propose alternate dosing regimens with Methods We retrospectively reviewed ≥13 years old for whom serum linezolid trough concentration ( C min ) was measured during treatment. Patients episodes infection divided into groups by presence impairment (RI group)...
Linezolid has antibacterial activity against aerobic Gram-positive cocci, including methicillin-resistant Staphylococcus aureus (MRSA). Adjustment of the dose linezolid been proposed to be unnecessary in patients with reduced renal function. However, platelet counts and hemoglobin levels were shown significantly lower such than normal The population pharmacokinetic (PPK) was investigated MRSA infected dysfunction. concentrations serum measured by high-performance liquid chromatography. PPK...
Objectives: Antibody-drug conjugates (ADCs) are a rapidly emerging class of agents for therapeutic areas such as oncology, immunology, etc. The ADCs consist mixtures antibodies with different number drug molecules attached (DAR, to antibody ratio). For some purposes, fully mechanistic PK model including each component DARs will be useful, while measurements all the components rarely available. Instead, other types total (tAB) and unconjugated (T) often measured, but it is not so clear what...
Cisplatin (cis-diamminedichloro-platinum; CDDP) is a chemotherapeutic agent that frequently induces peripheral neuropathy characterized by mechanical allodynia. Herein, we aimed to determine the effects of valproic acid (VPA) on cisplatin-induced allodynia in rats and elucidate underlying mechanisms. A single administration VPA (150 mg/kg) transiently suppressed CDDP-induced allodynia, correlating with serum concentrations. Repeated before or after onset significantly attenuated even...
Clock genes encoding transcription factors that regulate circadian rhythms may inform chronomodulated chemotherapy, where time-dependent dose alterations might affect drug efficacy and reduce side effects. For example, inhibiting the essential cystine transporter xCT with sulfasalazine induces growth arrest in cancer cells. Although anticancer effects of have been studied extensively, its on transcriptional control expression not studied. Here, we show administration during period increased...
We evaluated the pharmacokinetics of linezolid in case an obese Japanese patient (body weight 116 kg; body mass index 37 kg/m2). Linezolid was administered at a dose 600 mg by intravenous drip infusion for 60–90 min 12-h intervals. The results showed increased clearance and reduced serum concentration compared to population pharmacokinetic parameters, with trough levels below 90% minimum inhibitory concentration. However, effective improving lung infection inflammation our patient, which may...
In recent years, carbapenem-resistant Acinetobacter baumannii infections have been responsible for outbreaks in medical facilities. A 35-year-old Japanese woman developed a skin and soft tissue infection due to A. baumannii. The isolate was resistant antibiotics other than ampicillin–sulbactam colistin, suggesting drug resistance carbapenemase production by OXA-23. We selected combination therapy consisting of intravenous meropenem. No changes were observed aspartate aminotransferase,...
Linezolid is an oxazolidinone antibiotic that effectively treats methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Since rifampicin induces other effects, it combined with linezolid in therapeutic regimes. However, blood concentrations are reduced by this combination, which increases the risk of emergence antibiotic-resistant bacteria. We herein demonstrated combination inhibited its absorption promoted elimination, but not through microsomal...