A5008059577- Pharmacological Effects of Natural Compounds
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Natural product bioactivities and synthesis
- Bacterial Identification and Susceptibility Testing
- Surgical site infection prevention
- Nuclear and radioactivity studies
- Phytochemistry and biological activity of medicinal plants
- Metastasis and carcinoma case studies
- Graphite, nuclear technology, radiation studies
- Gastric Cancer Management and Outcomes
- Orthopedic Infections and Treatments
- Phytochemistry and Bioactive Compounds
- Polysaccharides and Plant Cell Walls
- Antibiotic Resistance in Bacteria
- Gastrointestinal Tumor Research and Treatment
- Surgical Simulation and Training
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Respiratory viral infections research
- Infection Control and Ventilation
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
Kagoshima University Hospital
2016-2025
Kagoshima University
2011-2025
National Hospital Organization Hokkaido Medical Center
2022-2024
Iwate Medical University
2017-2023
Hokkaido University
2013-2016
Obayashi (Japan)
1999-2015
Shizuoka Children's Hospital
2014
Sapporo Kosei General Hospital
2000-2012
University of Toyama
2010
Yokohama City University
2007
By the selective breeding of obese male mice ddY strain and using indices heavy body weight appearance urinary glucose, we established two inbred strains in 1992: one with obesity glucose (Tsumura, Suzuki, Obese Diabetes: TSOD) other without them Non Obesity: TSNO). The TSOD constantly showed signs increases food water intake, some fat weight. mass index (BMI) clearly moderate obesity. Increases levels diabetic blood parameters (glucose, insulin lipids) were also found males, which high to...
Rat genomic regions covering c-myc were cloned from the DNA of both normal liver and two lines Morris hepatomas, one which had amplification. The three restriction maps showed perfect agreement within overlapping regions. 7 kb regions, included entire rat region 2.2 upstream, sequenced found to be identical. coding exons 2 3 highly conserved between rat, mouse man, but some differences in amino acids noted. Exon 1 non-coding exon limited homology species. contained several nonsense codons...
The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is great concern. We clarified the risk factors underlying CRE infection mortality in Japan.We conducted a retrospective, multicentre, observational cohort study patients with infections at 28 university hospitals from September 2014 to December 2016, using Japanese National Surveillance criteria. Clinical information, including patient background, type infection, antibiotic treatment, and treatment outcome,...
Background The incidence of ocular candidiasis (OC) in patients with candidemia varies across different reports, and the issue whether routine ophthalmoscopy improves outcomes has been raised. This study investigated OC evaluate extent impacts clinical outcomes. Methods retrospective included non-neutropenic who underwent treatment at one 15 medical centers between 2010 2016. Chorioretinitis without other possible causes for lesions endophthalmitis was classified as a probable OC. If signs...
Summary Background Hepatotoxicity and visual symptoms are common adverse effects (AEs) of voriconazole therapy. Objective To retrospectively evaluate the treatment modification based on therapeutic drug monitoring AEs in patients undergoing Methods The target trough concentration ( C min ) was 1‐5 µg/mL. Receiver operating characteristic curves were used to determine cut‐offs for AEs. Results A total 401 included. Among 108 with high initial , discontinued 32 dose reduced 71. 44 low 4...
This study was conducted to obtain effective cancer chemopreventive agents with low toxicity from medicinal herbs. The effect of aqueous extracts 9 herbs antiinflammatory were examined on the formation azoxymethane (AOM)-induced aberrant crypt foci (ACF), putative preneoplastic lesions colon. Male F344 rats treated 15 mg/kg body weight AOM once a week for two weeks. Herbal extract consisting 2% diet administered 1 d prior first carcinogen treatment. number AOM-induced ACF per colon counted...
Biofilms play a pivotal role in medical device-related infections. However, epidemiological analysis of biofilm formation and genotyping among clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with orthopaedic infections has rarely been reported. A total 168 MRSA strains were examined: 23 infection (the device group); 55 device-non-related nondevice 90 asymptomatic nasal carriers colonization group). Pulsed-field gel electrophoresis five methods including agr...
Surgical site infection (SSI) has not been extensively studied in musculoskeletal tumors (MST) owing to the rarity of disease. We analyzed incidence and risk factors SSI MST. was evaluated consecutive 457 MST cases (benign, 310 malignant, 147 cases) treated at our institution. A detailed analysis clinical background patients, pre- postoperative hematological data, other that might be associated with performed for malignant cases. occurred 0.32% 12.2% benign cases, respectively. The duration...
: Compared with vancomycin trough concentration (Cmin)-guided dosing, area under the concentration–time curve (AUC)-guided dosing is associated decreased acute kidney injury (AKI). However, whether Cmin-guided or AUC-guided should be used in patients other than those serious MRSA infections remains uncertain. The purposes of this multicentre study were to identify risk factors for early- and late-phase vancomycin-induced AKI candidates rather who require a more accurate dose titration reduce...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral infectious disease high mortality. It causes multiple organ dysfunction; however, myocarditis has never been reported as a complication SFTS. A 62-year-old previously healthy woman developed fever, fatigue, diarrhea, and mild consciousness disorder. She visited local clinic, laboratory data showed leukocytopenia, thrombocytopenia, elevation of the aspartate aminotransferase level. was transferred to Kagoshima University...
Abstract Background Underlying immunodeficiencies are a concern due to the risk of persistent infections SARS-CoV-2. The Delta Substrain AY.29 with casirivimab/imdevimab escape mutations was detected from patients who diagnosed as COVID-19 while hospitalized in hematology ward. This study aims investigate factors leading and propose measures strengthen control nosocomial infections.Figure 1.Epidemic curve based on day positive SARS-CoV-2 PCR test (A) symptom onset (B) outbreak.Epidemic...
Abstract Background In recent years, community-acquired (CA) MRSA has become a problem, but there have been few reports of genotypes in the ICU. our ICU, we reinforced countermeasures such as screening for carriers using nasal specimens at admission and every week thereafter decolonizing those who test positive mupirocin. This study aimed to investigate prevalent strains intensive care setting their risk based on genotyping from patients admitted ICU.Figure 1.Comparison number detections by...
Abstract Background In a field where few reports have been made on the efficacy of SARS-CoV-2 vaccines in healthcare settings. We experienced an outbreak alpha variant medical institution cluster after workers were vaccinated, providing novel perspective topic.Figure 1.Epidemic curve based day positive PCR test (A) or symptom onset (B) during this COVID-19 The index case was patient admitted to hospital 24 May. last detected ten days first detection, but 42 patients, including five...
Abstract Introduction The survival benefits of treatment at high-volume hospitals (HVHs) are well-documented for several critical pediatric conditions. However, their impact on sepsis, a leading cause mortality among children, remains understudied. Aim the study To investigate association between hospital case volume and rates in sepsis. Material Methods We conducted retrospective cohort using data from Diagnosis Procedure Combination database. included patients who met following criteria:...
A bedside scoring system to assess the severity of disease is lacking for candidaemia. The Pitt candidaemia score (PCS) was evaluated its association with mortality. PCS consists five components, namely dialysis, hypotension, mechanical ventilation, cardiac arrest and mental status. Patients were classified into four categories according their PCS. correlation between category at blood culture collection 30 day mortality studied individually Candida species. Leading rates observed in...
"Juzen-Taiho-To" (TJ-48), which is a kampo (Japanese herbal) medicine prepared by decocting prescription of ten kinds herbs, has several immunostimulating activities. In order to characterize the active substances for anti-complementary and mitogenic activities, TJ-48 was fractionated. Anti-complementary activity observed in water- methanol-insoluble fraction (F-2) crude polysaccharide (F-5), whereas only found F-5. However, other low molecular mass fractions did not show both Methylation...
Cervical cancer is one of the most common cancers in women. The development new therapies with immune checkpoint inhibitors (ICIs) being investigated for cervical cancer; however, their efficacy not currently sufficient. Oncolytic virus therapy can increase tumor immunogenicity and enhance antitumor effect ICIs. In this report, therapeutic potential a triple-mutated oncolytic herpes (T-01) an ICI human papillomavirus (HPV)-related was evaluated using bilateral syngeneic murine model....
ABSTRACT Enteroaggregative Escherichia coli (EAEC) causes acute or persistent diarrhea. The aggR gene is widely used as a marker for typical EAEC. heterogeneity of EAEC well known; however, there are few reports on the phylogenetic relationships Recently, CTX-M extended-spectrum β-lactamase (ESBL)-producing strains have been reported worldwide. To characterize in Japan, we investigated population structure A total 167 -positive isolated from stool specimens diarrheal patients Kagoshima (139...