A5058136322- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Occupational and environmental lung diseases
- Inhalation and Respiratory Drug Delivery
- Eosinophilic Disorders and Syndromes
- Occupational exposure and asthma
- Medical Imaging and Pathology Studies
- Immune Cell Function and Interaction
- Inflammatory Myopathies and Dermatomyositis
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Lung Cancer Research Studies
- Pulmonary Hypertension Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Dysphagia Assessment and Management
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
Hamamatsu University School of Medicine
2016-2025
Hamamatsu University Hospital
2019-2024
Keio University
2024
Hamamatsu University
2018-2024
Soka Municipal Hospital
2018-2022
Chung Shan Medical University Hospital
2021
Center for Rheumatology
2021
Tottori University
2021
Mie prefectural Matsusaka Technical High School
2019
National University of Singapore
2017-2018
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Tuberculosis (TB) continues to be a major health problem, and there are few biomarkers for predicting prognosis. Indoleamine 2,3-dioxygenase (IDO), potent immunoregulatory molecule, catalyzes the rate-limiting step of tryptophan (Trp) degradation in kynurenine (Kyn) pathway. An increase IDO activity determined by serum Trp/Kyn ratio has been shown associated with poor prognosis cancers bacteremia. In TB, however, no studies measuring determine its clinical significance. We evaluated 174...
Change in body composition with skeletal muscle wasting, a major component of pulmonary cachexia, is associated mortality chronic obstructive disease and cancer. However, its relevance interstitial lung diseases (ILDs) remains unclear. We hypothesized changes would be ILDs. measured the cross-sectional-area (ESMCSA) attenuation (ESMMA) erector-spinae muscles, as determined by CT-imaging, patients idiopathic fibrosis (IPF; n = 131) pleuroparenchymal fibroelastosis (iPPFE; 43) controls....
Macrophage-mannose receptor, CD206, is a marker of alternatively activated macrophages. Activated macrophages play key roles in DM. Interstitial lung disease (ILD) leading cause mortality patients with DM/clinically amyopathic DM (CADM). In particular, the anti-melanoma differential gene 5 antibody (MDA5) frequently develop fatal rapid progressive ILD. This study aimed to evaluate clinical implications CADM/DM-ILD anti-MDA5 (MDA5-CADM/DM-ILD).We measured serum concentrations soluble CD206...
Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations macrophages are found in infected sites; thus, we hypothesized that marker activated may be related to prognosis pulmonary TB (PTB). This study investigated serum soluble macrophage mannose receptor, sCD206, PTB and examined its clinical significance. First, the concentration sCD206 was measured sera 96 patients with (Tenryu cohort), pleural effusions from 29 pleurisy. These were verified another independent...
The coronavirus disease 2019 (COVID-19) pandemic has dramatically changed because of virus mutations, vaccine dissemination, treatment development and policies, among other factors. These factors have a dynamic complex effect on the characteristics outcomes patients. Therefore, there is an urgent need to understand those changes update evidence. We used large-scale real-world data set 937,758 patients with COVID-19 from nationwide claims database that included outpatients inpatients in Japan...
Abstract Background and Objective Idiopathic pulmonary fibrosis (IPF) is characterized by progressive lung of unknown aetiology. Epidemiological studies have suggested that IPF progression may negatively affect nutritional status. Weight loss during antifibrotic therapy also frequently encountered. The association status outcome has not been fully evaluated in patients. Methods This retrospective multicohort study assessed 301 patients receiving (Hamamatsu cohort, n = 151; Seirei 150)....
Although a possible association among myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA), microscopic polyangiitis (MPA), and idiopathic pulmonary fibrosis (IPF) has been suggested, the clinical significance of MPO-ANCA in interstitial pneumonias (IIPs), including IPF non-IPF, remains unclear. We aimed to investigate frequency positivity, as well MPA incidence risk factors for development patients initially diagnosed with IIP.We retrospectively analysed 305 consecutive who were...
Macrophage activation is involved in the pathogenesis of polymyositis (PM)/dermatomyositis (DM). CD163, a scavenger receptor expressed on surface activated macrophages, mediates anti-inflammatory functions. This study aimed to evaluate clinical significance soluble CD163 (sCD163) PM/DM-related interstitial lung disease (ILD).The main subjects were 48 patients with ILD. As controls, 10 PM/DM without ILD and 20 healthy volunteers enrolled. In ILD, baseline characteristics course obtained...
Abstract Purpose Tryptophan metabolites have immunomodulatory functions, suggesting possible roles in cancer immunity. Methods Plasma tryptophan were measured using liquid chromatography/mass spectrometry before immune checkpoint inhibitors (ICIs) patients with non-small cell lung (NSCLC). Results The 19 NSCLC had significantly lower levels of ( p = 0.002) and xanthurenic acid 0.032), a higher level 3-hydroxyanthranilic (3-HAA) 0.028) compared the 10 healthy volunteers. achieving objective...
Abstract Background Lipids have immunomodulatory functions and the potential to affect cancer immunity. Methods The associations of pretreatment serum cholesterol long-chain fatty acids with objective response rate (ORR), progression-free survival (PFS), overall (OS) were evaluated in 148 patients non-small cell lung who received nivolumab. Results When each lipid was separately evaluated, increased low-density lipoprotein (LDL)-cholesterol ( P < 0.001), high-density (HDL)-cholesterol =...
Abstract Background Patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD), like those idiopathic pulmonary fibrosis (IPF), might develop an unexpected acute exacerbation (AE)—a rapidly progressing and deadly respiratory decline. Although AE incidence risk factors in RA-ILD patients are known, their post-AE clinical course remains unknown owing to the rarity of AE-RA-ILD. This multicentre retrospective study evaluated mortality prognostic variables AE-RA-ILD created...
The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is great concern. We clarified the risk factors underlying CRE infection mortality in Japan.We conducted a retrospective, multicentre, observational cohort study patients with infections at 28 university hospitals from September 2014 to December 2016, using Japanese National Surveillance criteria. Clinical information, including patient background, type infection, antibiotic treatment, and treatment outcome,...
Obesity is a common comorbidity in patients with asthma, and obese asthma present the most refractory phenotype among severe asthma. Similar to observations non-obese patients, clinical studies have revealed heterogeneity including occurrences of T helper (Th)2-high Th2-low phenotypes. However, mechanisms underlying obesity-related are not completely understood. Though macroautophagy/autophagy involved obesity, its role obesity-associated unknown. We hypothesized that autophagy pathogenesis...
Objective. Interstitial lung disease (ILD) is involved in polymyositis/dermatomyositis (PM/DM), a associated with poor prognoses. Chitinase-3-like-1 protein (YKL-40) has pleiotropic biological activities inflammation, cell proliferation, and tissue remodeling; however, the clinical application of YKL-40 remains limited. We investigated significance PM/DM–ILD. Methods. Sixty-nine consecutive patients PM/DM–ILD 34 healthy controls were analyzed. measured baseline followup serum using an ELISA,...
Abstract CD206, a mannose receptor, is mainly expressed on the surface of alternatively activated macrophages where it acts as pattern recognition receptor and plays role in innate adaptive immunity. This study investigated serum soluble CD206 (sCD206) levels community-acquired pneumonia (CAP) examined their clinical significance. sCD206 concentrations were measured sera two independent cohorts with CAP (127 125 patients, respectively) 42 controls. The expression lung from autopsied cases...
Recent research has highlighted the fundamental role of sarcopenia, characterized by loss skeletal muscle mass and strength, with a risk poor outcomes. AFT preserves lung function preventing annual decline in FVC is associated improved outcomes patients IPF. However, altered cause death prognostic implications sarcopenia IPF receiving remain unknown.This study comprised two cohorts AFT, historical cohort without controls. The mortality was compared cohort. Sarcopenia assessed measuring...
ABSTRACT Background and objective The efficacy of combination therapy with corticosteroids CNI, TAC CsA, for PM/DM‐ILD has been described retrospectively. However, it remains unknown which CNI treatment regimens, or CsA are more effective as initial treatments patients PM/DM‐ILD. Methods We conducted a prospective multicentre, open‐label, randomized, 52‐week phase 2 trial. Patients were randomly allocated to receive PSL plus (TAC group) (CsA group). primary endpoint was PFS rate in the...