A5085176505- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Treatments and Mutations
- Systemic Sclerosis and Related Diseases
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Pleural and Pulmonary Diseases
- Kawasaki Disease and Coronary Complications
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Salivary Gland Disorders and Functions
- Occupational exposure and asthma
- Oral and Maxillofacial Pathology
- Gastric Cancer Management and Outcomes
- Inflammatory Myopathies and Dermatomyositis
- Soft tissue tumor case studies
- Genetic factors in colorectal cancer
- Neonatal Respiratory Health Research
- Lymphoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Eosinophilic Disorders and Syndromes
- Pancreatic and Hepatic Oncology Research
Hamamatsu University School of Medicine
2016-2025
Hamamatsu University
2024
Hamamatsu University Hospital
2024
Toyohashi Municipal Hospital
2024
RIKEN Center for Biosystems Dynamics Research
2021-2023
Toho University Ohashi Medical Center
2015-2019
Toho University
2015-2019
Tokyo University of Pharmacy and Life Sciences
2019
Nara Medical University
2005-2018
Kanagawa Cardiovascular and Respiratory Center
2013-2016
The molecular etiology of idiopathic pulmonary fibrosis (IPF) has been extensively investigated to identify new therapeutic targets. Although anti-inflammatory treatments are not effective for patients with IPF, damaged alveolar epithelial cells play a critical role in lung fibrogenesis. Here, we establish an organoid-based model using mouse and human tissues assess the direct communication between type II (AT2)-lineage fibroblasts by excluding immune cells. Using this vitro genetics,...
Introduction Interstitial lung disease associated with primary Sjögren’s syndrome (pSS–ILD) shows several patterns such as nonspecific interstitial pneumonia (NSIP) and usual (UIP). Although UIP is a well–recognized prognostic determinant in idiopathic pneumonias, whether this also the case pSS–ILD unclear. The objectives of study were to evaluate effect UIP, identify factors pSS–ILD. Methods A retrospective review medical records identified 33 consecutive patients pathologically–proven Each...
Change in body composition with skeletal muscle wasting, a major component of pulmonary cachexia, is associated mortality chronic obstructive disease and cancer. However, its relevance interstitial lung diseases (ILDs) remains unclear. We hypothesized changes would be ILDs. measured the cross-sectional-area (ESMCSA) attenuation (ESMMA) erector-spinae muscles, as determined by CT-imaging, patients idiopathic fibrosis (IPF; n = 131) pleuroparenchymal fibroelastosis (iPPFE; 43) controls....
Radiologic pleuroparenchymal fibroelastosis (PPFE)-like lesion including pulmonary apical cap can be occasionally observed in clinical settings. However, the significance of radiologic PPFE-like is unclear connective tissue disease (CTD)-related interstitial lung (ILD).A total 113 patients with CTD-related ILD were enrolled and assessed for lesion, which was defined as bilateral, upper lobe, subpleural dense consolidations or without pleural thickening on chest high-resolution computed...
Multidisciplinary discussion (MDD) requiring close communication between specialists (clinicians, radiologists and pathologists) is the gold standard for diagnosis of idiopathic interstitial pneumonias (IIPs). However, MDD by not always feasible because they are often separated time location. An online database would facilitate data sharing MDD. Our aims were to develop a nationwide cloud-based integrated containing clinical, radiological pathological patients with IIPs along web-based...
Homozygous deletion of 9p21, the locus harboring p16 gene, has been reported as one most common genetic alterations in malignant mesotheliomas (MMs). Previous studies showed that this alteration might be useful for differentiating benign from mesothelial tumors cytology and surgical specimens. Although diagnostic utility 9p21 homozygous by fluorescence situ hybridization (FISH) analysis only recently, it not well demonstrated. The purpose study is to evaluate assessed FISH neoplasm...
This study investigated the clinical characteristics and predictive factors for developing acute extended radiation pneumonitis with a focus on presence radiological of preexisting interstitial lung disease.Of 1429 irradiations cancer from May 2006 to August 2013, we reviewed 651 involving field. The presence, compatibility usual pneumonia, occupying area disease were retrospectively evaluated by pretreatment computed tomography. Cases non-infectious, non-cardiogenic, respiratory failure an...
Macrophage activation is involved in the pathogenesis of polymyositis (PM)/dermatomyositis (DM). CD163, a scavenger receptor expressed on surface activated macrophages, mediates anti-inflammatory functions. This study aimed to evaluate clinical significance soluble CD163 (sCD163) PM/DM-related interstitial lung disease (ILD).The main subjects were 48 patients with ILD. As controls, 10 PM/DM without ILD and 20 healthy volunteers enrolled. In ILD, baseline characteristics course obtained...
Although differentiation of lung fibroblasts into α-smooth muscle actin (αSMA)-positive myofibroblasts is important in the progression idiopathic pulmonary fibrosis (IPF), few biomarkers reflecting fibrotic process have been discovered. We performed microarray analyses between FACS-sorted steady-state (lineage (CD45, TER-119, CD324, CD31, LYVE-1, and CD146)-negative PDGFRα-positive cells) from untreated mouse lungs (lineage-negative, Sca-1-negative, CD49e-positive bleomycin-treated lungs....
Deep learning technology has been used in the medical field to produce devices for clinical practice. methods cytology offer potential enhance cancer screening while also providing quantitative, objective, and highly reproducible testing. However, constructing high-accuracy deep models necessitates a significant amount of manually labeled data, which takes time. To address this issue, we Noisy Student Training technique create binary classification model cervical screening, reduces quantity...
The aim of this study was to characterize and delineate the broad histological spectrum hepatic angiomyolipoma (AML) obtain a better understanding its clinicopathological diagnosis by reviewing large series AMLs.According proportions three components, AML could be classified into 10 types; 36 55 tumours (65%) were as myomatous, eight myoangiomatous, six mixed (conventional), two lipomatous, myolipomatous, one lipomyomatous. morphology smooth muscle cells (SMCs) in quite variable, giving wide...
Objective. Interstitial lung disease (ILD) is involved in polymyositis/dermatomyositis (PM/DM), a associated with poor prognoses. Chitinase-3-like-1 protein (YKL-40) has pleiotropic biological activities inflammation, cell proliferation, and tissue remodeling; however, the clinical application of YKL-40 remains limited. We investigated significance PM/DM–ILD. Methods. Sixty-nine consecutive patients PM/DM–ILD 34 healthy controls were analyzed. measured baseline followup serum using an ELISA,...
Pneumothorax is a co-morbidity in patients with idiopathic pulmonary fibrosis (IPF). However, its incidence, risk factors and prognostic significance IPF remain unclear. The aim of this study was to clarify the incidence pneumothorax IPF, further investigate for onset.Eighty-four consecutive based on consensus guideline were included study. We retrospectively reviewed medical records, function tests chest high-resolution computed tomography images, determined pneumothorax. evaluated using...
The different characteristics of usual interstitial pneumonia in patients with primary Sjögren׳s syndrome (UIP/pSS) compared idiopathic pulmonary fibrosis (UIP/IPF) are not fully understood. This study aimed to compare characteristics, prognosis, and treatment responses these patients. Among 129 consecutive who underwent surgical lung biopsy diagnose diffuse diseases at Kanagawa Cardiovascular Respiratory Center between 1998 2002, we identified 10 19 UIP/pSS UIP/IPF, respectively. Baseline...
Anti-glycyl-tRNA synthetase (anti-EJ) antibody is occasionally positive in patients with interstitial lung disease (ILD). We aimed to define the clinical, radiological and pathological features of anti-EJ antibody-positive ILD (EJ-ILD). retrospectively analyzed medical records 12 consecutive EJ-ILD who underwent surgical biopsy. The median follow-up time was 74 months (range, 17–115 months). age 62 years 47–75 years). Seven were female. Eight presented acute onset. Six eventually developed...
<b><i>Background:</i></b> Idiopathic pleuroparenchymal fibroelastosis (PPFE) is a rare form of idiopathic interstitial pneumonia that characterized by predominantly upper lobe pleural and subpleural lung parenchymal fibrosis. Pneumothorax one the major respiratory complications in PPFE patients; however, its clinical features are poorly understood. <b><i>Objective:</i></b> We aimed to investigate complication pneumothorax patients with PPFE....