A5090116921- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotic Resistance in Bacteria
- Lung Cancer Treatments and Mutations
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Antimicrobial Resistance in Staphylococcus
- Eosinophilic Disorders and Syndromes
- Antibiotics Pharmacokinetics and Efficacy
- Renal Transplantation Outcomes and Treatments
- Sphingolipid Metabolism and Signaling
- Pulmonary Hypertension Research and Treatments
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Blood disorders and treatments
- Lung Cancer Diagnosis and Treatment
- Bacterial biofilms and quorum sensing
- Pleural and Pulmonary Diseases
- Lipid Membrane Structure and Behavior
- Neutropenia and Cancer Infections
- Viral Infections and Vectors
- Inhalation and Respiratory Drug Delivery
- Angiogenesis and VEGF in Cancer
- Listeria monocytogenes in Food Safety
- Pneumonia and Respiratory Infections
- Chronic Myeloid Leukemia Treatments
Tokushima University Hospital
2013-2024
Tokushima University
2007-2022
Ibero American University
2021
Institute of Biomedical Science
2019-2020
Center for Rheumatology
2010-2014
Institute of Medicinal Molecular Design
2006
Circulating fibrocytes have been reported to migrate into the injured lungs, and contribute fibrogenesis via CXCL12-CXCR4 axis. In contrast, we report that imatinib mesylate prevented bleomycin (BLM)-induced pulmonary fibrosis in mice by inhibiting platelet-derived growth factor receptor (PDGFR), even when it was administered only early phase. The goal of this study test hypothesis (PDGF) might directly migration lungs. PDGFR expression examined flow cytometry RT-PCR. evaluated using a...
Circulating fibrocytes had been reported to migrate into the injured lungs, and contribute fibrogenesis via chemokine-chemokine receptor systems including CXCL12-CXCR4 axis. Here we hypothesized that blockade of CXCR4 might inhibit migration lungs subsequent pulmonary fibrosis. To explore antifibrotic effects CXCR4, used a specific antagonist for AMD3100, in bleomycin-induced fibrosis model mice. Administration AMD3100 significantly improved loss body weight mice treated with bleomycin,...
Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of pulmonary fibrosis. Nintedanib, a multi-kinase inhibitor that targets several tyrosine kinases, including PDGF receptor (PDGFR), was recently approved as an anti-fibrotic agent to reduce deterioration FVC patients with idiopathic fibrosis (IPF). However, effects PDGFR-α or -β on remain unclear. In attempt clarify their effects, we herein used blocking antibodies specific for (APA5) and (APB5) bleomycin...
The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is great concern. We clarified the risk factors underlying CRE infection mortality in Japan.We conducted a retrospective, multicentre, observational cohort study patients with infections at 28 university hospitals from September 2014 to December 2016, using Japanese National Surveillance criteria. Clinical information, including patient background, type infection, antibiotic treatment, and treatment outcome,...
IkappaB kinase-beta is a critical regulator in the activation of nuclear factor-kappaB (NF-kappaB), transcription factor related to expression and regulation proinflammatory cytokines.To evaluate if inhibition ameliorates pneumonitis pulmonary fibrosis.We examined whether novel inhibitor, IMD-0354, attenuates bleomycin-induced fibrosis mice.Administration IMD-0354 significantly improved loss body weight survival mice treated with bleomycin, whereas alone did not cause any morphologic change...
Focal adhesion kinase (FAK) is a nonreceptor tyrosine involved in various biological functions, including cell survival, proliferation, migration, and adhesion. FAK an essential factor for transforming growth β to induce myofibroblast differentiation. In the present study, we investigated whether targeted inhibition of by using specific inhibitor, TAE226, has potential regulate pulmonary fibrosis. TAE226 showed inhibitory activity autophosphorylation at 397 lung fibroblasts. The addition...
Rationale: Imatinib is an inhibitor of platelet-derived growth factor receptors. We have reported that treatment with imatinib inhibited bleomycin-induced pulmonary fibrosis in mice. However, late had no effect.Objectives: To clarify why antifibrotic effect when its administration was delayed, we focused on α1-acid glycoprotein (AGP), because it to bind and mediate drug resistance.Methods: The concentration AGP serum mice patients idiopathic measured by radial immunodiffusion testing....
Purpose/Aim of the Study: Wnt/β-catenin signaling was reported to be activated in pulmonary fibrosis, and focused on as a target for antifibrotic therapy. However, mechanism how inhibition ameliorate fibrosis has not been fully elucidated. The purpose this study is explore cells examine effect novel inhibitor PRI-724 specifically disrupting interaction β-catenin CBP. Materials Methods: C-82, an active metabolite PRI-724, expression TGF-β1 α-smooth muscle actin (SMA) examined fibroblasts...
The soluble form of vascular endothelial growth factor receptor-1 (sVEGFR-1) is produced from cells by alternative splicing VEGFR-1 mRNA, and can inhibit angiogenesis blocking the biological effects VEGF. In this study, we show expression a large amount sVEGFR-1 in human monocyte-derived mature dendritic (mDCs). As compared with monocytes immature DCs, mDCs generated TNF-alpha or CD40L IFN-gamma, but not LPS other stimuli, preferentially produce sVEGFR-1. We also detected mRNA induced...
The therapeutic effects of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents, vancomycin (VCM), teicoplanin (TEIC), and arbekacin (ABK), depend on their concentrations in blood. Therefore, drug monitoring (TDM) is important when these antibiotics are used. In the hematological ward at Tokushima University Hospital, pharmacists have ordered measurement blood VCM, TEIC, ABK to promote use TDM accordance with an agreed protocol since 2013. Moreover, infection control team includes...
Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that characterized by proliferation fibroblasts increased deposition extracellular matrix. The CCN6/WISP-3 member CCN family matricellular proteins, which consists six members are involved in many vital biological functions. However, regulation mediated CCN6 protein has not been fully elucidated. Here, we demonstrated induced binding to integrin β1, leading phosphorylation FAKY397. Furthermore, showed weak, but...
Lung cancer is the leading cause of malignancy-related death worldwide. In present study, we reviewed epidemiologic and clinical features lung in Tokushima Prefecture, Japan. Between January 1999 December 2009, 2,183 patients with were enrolled this study. One thousand five hundred ninety-one (73%) male 592 (27%) female. Median age was 70 years, a range 15-93 years. Seventy-six percent had smoking history. nine (87%) non-small cell predominant histological type adenocarcinoma (51%). Among...
Fibrocytes, which are bone marrow-derived collagen-producing cells, were reported to play a role in the pathogenesis of pulmonary fibrosis.However, their function fibrosis is unclear.We analyzed compared with that monocytes and localization fibrotic tissues patients idiopathic (IPF).We gene expression profile monocyte-derived fibrocytes by microarray analysis.Proliferation differentiation into myofibroblasts examined 3 H-thymidine incorporation assay Western blotting.We measured level growth...