Wound infection is considered a significant challenge in skin injuries. Sprayable antibacterial wound dressings are interesting alternatives to their traditional counterparts because of facile preparation, ease-of-use, and the possibility topical delivery materials. Herein, novel sprayable formulated reported. The were developed by in-situ formation Ag-nanoparticles (Ag-NPs) using Persian gum (PG) as carbohydrate polymer. Several tests conducted investigate effect polymer concentration on...

Abstract Background Various methods were introduced to overcome the autograft shortage in burn wound care, including cell transplantation and tissue engineering. Aims To evaluate healing effect of allogenic human Wharton's jelly stem cells (hWJSCs) seeded onto acellular dermal matrix (ADM) rat injuries. Patients Methods Human provided from umbilical cord characterized before transplantation, growth kinetic was determined. Skin samples cosmetic surgeries used for preparation ADM. Forty male...

Abstract Background This study aimed to determine the therapeutic efficacy of curcumin nanoemulsion (CUR-NE) in mice infected with Echinococcus granulosus sensu stricto protoscoleces. Methods Forty-two inbred BALB/c were divided into seven groups six animals each. Six inoculated intra-peritoneally 1500 viable E. protoscoleces, followed for months and used as groups. The named as: CEI1 CEI6 accordingly. 7th group was not cystic echinococcosis noninfected (CENI7). CEI2 received 40 mg/kg/day 20...

Abstract AIM: To evaluate the adverse effects of flunixin, ketoprofen and phenylbutazone when administered I/V to clinically normal miniature donkeys. METHODS: Twenty adult (2.0–2.5 years old) male donkeys weighing 113–136 kg 0.81–0.86 m tall were randomly assigned one four groups, either saline (n=5), 1.0 mg/kg flunixin 2.2 or 4.4 (n=5) at 0800 hours on Day 1, then every 12 h, for days. The animals observed 8 examined physically daily. Blood, faeces urine samples collected daily from all...

Leishmaniasis is one of the diverse and neglected tropical diseases. Embryo-toxicity drugs has always been a major concern. Chick embryo preclinical model relevant in assessment adverse effects drugs. The current study aimed to assess embryonic histopathological disorders amniotic fluid biochemical changes following meglumine antimoniate treatment. alteration vascular branching pattern chick's extra-embryonic membrane exploration molecular cues early vasculogenesis angiogenesis were also...

Background: Developing chicken embryo culture techniques provides methods for manipulating embryos. In this study, the cell-based approach investigated human Wharton’s jelly stem cells (HWJSCs) proliferation and migration into internal embryonic chick tissue. Methods: were cultured on an acellular dermal matrix (ADM) seeded chorioallantoic membrane (CAM) of a 4-day-old embryo. Using RT-PCR assay with COLA-I gene, molecular analysis was performed liver tissue after hatching to confirm...

Introduction Wound dressings often fall short of providing the multifunctional capabilities required for optimal wound healing, such as promoting cell migration, proliferation, and tissue regeneration. Decellularization plant tissues has gained attention a potential source biomaterials engineering applications due to their favorable characteristics, including pre-existing vascular networks, interconnected porous structure, efficient water transport retention, high surface area, diverse range...

The objective of this study was to investigate the effects dopamine as vasodilator, vitamin C an antioxidant and combined administration them on ischaemia-reperfusion (I-R) injury following testicular torsion (TT). Thirty adult male rats were divided into six groups each containing five rats. Testicular ischaemia achieved by twisting left testis for 4 h. Group 1 determination basal values. 2 had h TT. 3 TT then treated with dopamine. C. 5 6 designed a sham operated group. caused significant...

Summary The clinical uses of gentamicin have so far been restricted due to nephrotoxicity and ototoxicity. exact mechanism is still unknown; however, it appears that free radicals may be involved. Methionine has previously shown alleviate oxidative stress involved in ototoxicity its antioxidant properties. Therefore, the effect methionine supplementation on induced was examined this study. Twenty eight male Wistar rats were randomly divided into 4 equal groups receive a daily corresponding...

One of the essential problems in burn therapy is performing permanent replacement skin full and deep thickness injuries. Human Wharton's Jelly mesenchymal stem cells (HWJMSCs) have a unique combination prenatal postnatal properties. Decellularized human amniotic membrane (DHAM) can be used as scaffold for HWJMSCs-therapy. We aimed to evaluate quantity quality healing early excision wound dressing with 3-dimensional 2- dimensional cell cultures.Amniotic umbilical cords were isolated from...

We report a 5-year-old gelding with rare benign tumour of 2-month duration in the subcutis hind limb that presented lameness. Physical examination revealed normal vital signs. Laboratory findings were within ranges. No bone abnormalities detected on radiographic affected area. Bloody fluid was obtained by aspiration. Through an I-shape skin incision excised en-block. Microscopic study showed vascular hamartoma characterized cavernous haemangiomatous tissue and proliferation multiple vessels...

Kidney injury is a deleterious side effect accompanied by therapeutic uses of cisplatin as an antineoplastic agent. However, no option available against this complication. This study was designed to evaluate the protective role glycoprotein extract obtained from Eisenia foetida cisplatin-induced nephrotoxicity. Rats were treated with (7.5 mg/kg, intraperitoneally, i.p.) and (300 500 i.p. and/or oral). Serum creatinine (Cr) blood urea nitrogen (BUN) significantly elevated in cisplatin-treated...