A5012469675- Cancer Immunotherapy and Biomarkers
- Gamma-ray bursts and supernovae
- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Sensors and Ion Detection
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Stellar, planetary, and galactic studies
- Lanthanide and Transition Metal Complexes
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Lymphoma Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- PI3K/AKT/mTOR signaling in cancer
- Pulsars and Gravitational Waves Research
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Immune cells in cancer
- Advanced Fluorescence Microscopy Techniques
- Ferroptosis and cancer prognosis
- Astrophysics and Cosmic Phenomena
- Electron Spin Resonance Studies
Lanzhou University
2020-2025
First Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Sun Yat-sen University
2021-2024
Sun Yat-sen University Cancer Center
2021-2024
State Key Laboratory of Oncology in South China
2022-2024
Qilu University of Technology
2022-2024
Shandong Academy of Sciences
2022-2024
Guangxi University
2022-2024
Nanchang Hangkong University
2021
The response to immune checkpoint inhibitors (ICIs) monotherapy remains unsatisfactory in patients with NSCLC. Thus, combining ICIs other potential modalities is of great significance enhance the single drug alone. Here, we identified that HIF-1α inhibition was capable promoting anti-tumor immunity We applied NSCLC cell lines and mouse models evaluate synergy combined PD-1 blockade on tumor growth function infiltrating lymphocytes (TILs). Public datasets were utilized investigate patients'...
Long-duration gamma-ray bursts (GRBs) associated with supernovae (SNe) are believed to originate from massive star core-collapse events, whereas short-duration GRBs that related compact mergers expected be accompanied by kilonovae. GRB 211227A, which lasted about 84 s, had an initial short/hard spike followed a series of soft extended emission at redshift $z=$0.228. We performed follow-up observations the optical using BOOTES, LCOGT, and Lijiang 2.4m telescope, but we detected no supernova...
Abstract The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to immunosuppressive tumor microenvironment and lack sufficient infiltration activated CD8+ T cells. Transforming (TME) from “cold” “hot” thus more likely potentiate effects ICIs is a promising strategy for cancer treatment. We found that selective BCL-2 inhibitor APG-2575 can enhance antitumor efficacy anti-PD-1 therapy syngeneic humanized CD34+ mouse models. Using single-cell RNA sequencing, we...
Background Immune checkpoint inhibitors (ICIs) have achieved substantial advancements in clinical care. However, there is no strong evidence for identified biomarkers of ICIs NPC.
Abstract Advanced nasopharyngeal carcinoma (NPC) has a poor prognosis, with an unfavorable response to palliative chemotherapy. Unfortunately, there are few effective therapeutic regimens. Therefore, we require novel treatment strategies enhanced efficacy. The present study aimed investigate the antitumor efficacy of APG-1252-M1, dual inhibitor BCL-2/BCL-XL, as single agent and combined gemcitabine. We applied various apoptotic assays used subcutaneous transplanted NPC model assess in vitro...
ADG106, a ligand-blocking agonistic antibody targeting CD137 (4-1BB), exhibits promising results in preclinical studies, demonstrating tumor suppression various animal models and showing balanced profile between safety efficacy. This phase 1 study enrolls 62 patients with advanced malignancies, revealing favorable tolerability up to the 5.0 mg/kg dose level. Dose-limiting toxicity occurs only one patient (6.3%) at 10.0 mg/kg, resulting grade 4 neutropenia. The most frequent treatment-related...
<h3>Background:</h3> Recent studies have identified empathy deficit as a core impairment and diagnostic criterion for people with autism spectrum disorders; however, the improvement of focuses primarily on behavioural interventions without target regulation. We sought to compare brain regions associated empathy-like behaviours fear pain, explore role oxytocin–oxytocin receptor system in empathy. <h3>Methods:</h3> used C57BL mice establish 2 models pain employed immunofluorescence...
Abstract Mrk 501 is a prototypical high-synchrotron-peaked blazar and serves as one of the primary targets for Imaging X-ray Polarimetry Explorer (IXPE). In this study, we report polarization measurements based on six IXPE observations. The detection at confidence level exceeding 99% achieved in four out observations conducted across entire energy range (2–8 keV) IXPE. maximum degree (Π X ) measured to be 15.8% ± 2.8%, accompanied by angle ( ψ 98.°0 5.°1 5.6 σ . During remaining two...
Abstract Chronic social stress (CSS) is a significant public health challenge that negatively impacts behavior and immune function through brain‐spleen interactions. Oxytocin (OT), neuropeptide critical for regulation, upregulated during CSS, though its underlying mechanisms remain unclear. This study investigates the role of OT in splenic modulation using murine model CSS. Behavioral evaluations, serum oxytocin quantification, immunophenotypic analysis were performed. Splenic denervation...
Radioactive iodine therapy (RAIT) is one of the main treatment methods for patients with papillary thyroid carcinoma (PTC). Peripheral blood samples were collected from 29 PTC who underwent total thyroidectomy 1-2 days before RAIT (RAIT-0), 30 after (RAIT-30), and 90 (RAIT-90). Flow cytometry was used to detect absolute counts peripheral lymphocyte subpopulations, Proximity Extension Assay (PEA) targeted proteome quantification. We found that RAIT, subpopulations abundance...
Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC) is unknown.NSCLC undergoing radical resection subsequent from 2013 to 2017 at Sun Yat-sen University Center were retrospectively reviewed. Fasted levels measured chemotherapy. The optimal cut-off values baseline fluctuation determined using X-tile™. fluctuations disease-free (DFS)...
The sustained effectiveness of anti-programmed cell death protein-1/programmed death-ligand 1 treatment is limited to a subgroup patients with advanced nasopharyngeal carcinoma (NPC), and the specific biomarker determining response immunotherapy in NPC remains uncertain. We assessed associations between pre-immunotherapy post-immunotherapy serum lipoproteins survival training cohort (N=160) corroborated these findings validation (N=100). Animal studies were performed explore underlying...
Abstract We present optical photometry for the afterglow of GRB 221009A, in some respects most extraordinary gamma-ray burst (GRB) ever observed. Good quality R -band light curve is obtained, covering 0.32–19.57 days since Fermi-Gamma-Ray Burst Monitor trigger. find that a weak bump emerges from declining at t ≈ 11 days; supernova (SN) may be responsible. use smooth broken power-law and 56 Ni model to fit curve. The best-fitting results reveal SN ejected total mass M ej = 3.70 ⊙ , 0.23...
Abstract The power density spectrum (PDS) is a powerful tool to study light curves of gamma-ray bursts (GRBs). We show the average PDS and individual analysis with GRB data from Hard X-ray Modulation Telescope (also named Insight-HXMT). values power-law index ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:msub> <mml:mrow> <mml:mi>α</mml:mi> </mml:mrow> <mml:mover accent="true"> <mml:mi>P</mml:mi> <mml:mo>¯</mml:mo> </mml:mover> </mml:msub> </mml:math> )...
Immunotherapy has shown promising efficacy in patients with nasopharyngeal carcinoma (NPC). Lymphocyte activating 3 gene (LAG-3) represents a significant immune target, however, its relationship NPC remains unclear. This study aimed to evaluate LAG-3 expression and association CD3+ tumor-infiltrating lymphocytes (TILs), Granzyme B (GZMB), programmed death ligand 1 (PD-L1), (PD-1) expression.A total of 182 from Sun Yat-sen University Cancer Center, China, were included this retrospective...
End-stage nasopharyngeal carcinoma (NPC) has unsatisfactory survival. The limited benefit of chemotherapy and the scarcity targeted drugs are major challenges in NPC. New approaches to treat late-stage NPC urgently required. In this study, we explored whether dual PI3K/mTOR inhibitor, PQR309, exerted a favorable antineoplastic effect sensitized response gemcitabine We observed that PI3K expression was positive elevated 14 cell lines compared with normal nasopharygeal lines. Patients higher...
Abstract TP53 comutation is related to poor prognosis of non‐small cell lung cancer. However, there limited study focusing on the structural influence mutation third‐generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) treatment. We retrospectively analyzed clinical and molecular data patients treated with EGFR‐TKIs in two independent cohorts. A total 117 from Sun Yat‐sen University Cancer Center (SYSUCC) 141 American Association for Research Project GENIE...