A5040059735- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Plant chemical constituents analysis
- Synthesis of Indole Derivatives
- Burn Injury Management and Outcomes
- Virology and Viral Diseases
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Peptidase Inhibition and Analysis
- Cyclization and Aryne Chemistry
- Human-Animal Interaction Studies
- Injury Epidemiology and Prevention
- Cardiac Arrest and Resuscitation
- Chemical Synthesis and Analysis
- Rabies epidemiology and control
- Chemical synthesis and alkaloids
Pennsylvania State University
2024
William & Mary
2019-2024
Williams (United States)
2019-2024
Colonial Williamsburg Foundation
2019
The Glaser–Hay bioconjugation has emerged as an efficient method to generate bioconjugates with therapeutic applications.
Antibiotic resistance is a growing problem facing global societies today. Many new antibiotics are derivatized versions of already existing antibiotics, which allows for antibiotic to arise. To combat this issue, with different core structures need be elucidated. Asymmetrical polyacetylenes have been isolated from natural products and they previously demonstrated exhibit antimicrobial antibacterial activity; however, their synthetic preparation has not made them easily amenable rapid...
The development of new antibiotics with unique mechanisms action is paramount to combating the growing threat antibiotic resistance. Recently, based on inspiration from natural products, an asymmetrical polyacetylene core structure was examined for its bioactivity and found have differential specificity different bacterial species substituents around conjugated alkyne. This research further probes structural requirements through a systematic synthesis investigation compounds variable carbon...