A5057268200- Parathyroid Disorders and Treatments
- Bone and Dental Protein Studies
- Acute Kidney Injury Research
- Heterotopic Ossification and Related Conditions
- Organ Transplantation Techniques and Outcomes
- Dermatological and Skeletal Disorders
- Cardiac Ischemia and Reperfusion
- Magnesium in Health and Disease
- Urological Disorders and Treatments
- Digestive system and related health
- Mercury impact and mitigation studies
- Bone health and osteoporosis research
- Complement system in diseases
- Renal Transplantation Outcomes and Treatments
- Helicobacter pylori-related gastroenterology studies
- Kidney Stones and Urolithiasis Treatments
- Dialysis and Renal Disease Management
- Clinical Nutrition and Gastroenterology
- Eosinophilic Esophagitis
- Bone health and treatments
- Gastroesophageal reflux and treatments
- Vitamin D Research Studies
- Biomedical Research and Pathophysiology
- Selenium in Biological Systems
- Medical Imaging and Pathology Studies
University of Antwerp
1999-2010
University Medical Center Utrecht
2004
ABSTRACT. Nephrolithiasis requires formation of crystals followed by their retention and accumulation in the kidney. Crystal can be caused association with epithelial cells lining renal tubules. The present study investigated interaction between calcium oxalate monohydrate (COM) primary cultures human proximal (PTC) distal tubular/collecting duct (DTC). Both PTC DTC were susceptible to crystal binding during first days post-seeding (4.9 ± 0.8 μg COM/cm2), but lost this affinity when...
Background. Hyperphosphataemia is a risk factor for arterial calcification contributing to the high cardiovascular mortality in patients with chronic kidney disease. Calcium-based phosphate binders can induce hypercalcaemia and are associated progression of vascular calcification. Therefore, effect lanthanum carbonate, non-calcium binder, on development was investigated uraemic rats. Methods. Chronic renal failure (CRF) induced by feeding rats an adenine-enriched diet 4 weeks. After 2 weeks,...
Objective— To investigate cell biological changes in calcified aortas of rats that experienced chronic renal failure. Methods and Results— Vascular smooth muscle cells have the potential to transdifferentiate either chondrocytes or osteoblasts, depending on molecular pathways are stimulated. Uremia-related medial calcification was induced by feeding an adenine low-protein diet for 4 weeks. Aortic evaluated biochemically histochemically with vivo micro–computed tomographic scanning....
Background. The effect of segment‐specific proximal tubular injury on spatio‐temporal osteopontin (OPN) distribution was determined in two different nephrotoxic rat models to evaluate its conceivability with a possible role for OPN acute renal failure (ARF). gene expression further and distal cells investigate the origin increased OPN.
Abstract Introduction Beside lung transplantation, cardiopulmonary bypass, isolated perfusion and sleeve resection result in serious pulmonary ischemia–reperfusion injury, clinically known as acute respiratory distress syndrome. Very little is about cells infiltrating the during ischemia–reperfusion. Therefore, a model of warm injury was applied to differentiate cellular infiltrates quantify tissue damage. Methods Fifty rats were randomized into eight groups. Five groups underwent ischemia...
Chronic renal failure (CRF) is associated with a 10- to 20-fold increase in cardiovascular risk. Vascular calcification prominent feature of disease patients end-stage and contributes the excess mortality this population. In study, we explored vivo X-ray microtomography (micro-CT) as tool detect follow-up vascular calcifications aorta living rats adenine-induced CRF.With micro-CT, uremic was clearly discernible on transversal virtual cross-sections. Micro-CT findings correlated well tissue...
<i>Background:</i> Increased bone loss has been associated with the development of vascular calcification in patients chronic renal failure (CRF). In this study, effect impaired metabolism on aortic calcifications was investigated uremic rats or without ovariectomy. <i>Methods:</i> CRF induced by administration a 0.75% adenine/2.5% protein diet for 4 weeks. one group, osteoporosis ovariectomy (CRF-OVX), while other group underwent sham-operation instead A third...
ABSTRACT. In normal human and rat kidneys, osteopontin (OPN) is present at the apical surface of cells in distal nephron. After ischemic or toxic renal damage rats, OPN upregulated tubular (DTC) expressed de novo perinuclear vesicles proximal (PTC). first phase this study, localization biopsies was compared with that kidneys. second phase, cultures PTC DTC were used to investigate synthesis, secretion, localization. after ischemia comparable Microscopic flow cytometric detection...
Experts from all continents discussed the present and future of nephrology transplantation medicine in emerging countries during a 3-day conference, supported by World Health Organization, International Society Nephrology, Transplantation Society-Global Alliance for Ministry Republic Mali. This conference was held Bamako, Mali on December 4-6, 2008, focused prevention treatment chronic kidney disease countries. Apart delivering high-quality medical scientific knowledge, meeting mainly call...
Adoption of the EU Medical Devices Regulations and In Vitro Diagnostics has led to increased demand for systematic literature reviews. This article reports on a survey investigating current use software platforms tools by regulatory medical writers others involved in conducting The was completed 125 respondents from 31 countries, evenly spread across different levels experience. Most partially automated (35%) or fully manual process (59%). Familiarity with specific conduct reviews low, most...