A5026703720- Protease and Inhibitor Mechanisms
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Plant Toxicity and Pharmacological Properties
- Aortic aneurysm repair treatments
- Human Health and Disease
- Sirtuins and Resveratrol in Medicine
- Bone and Dental Protein Studies
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Muscle Physiology and Disorders
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Bee Products Chemical Analysis
- Dental materials and restorations
- Medical and Biological Ozone Research
- Bone Tissue Engineering Materials
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Business and Management Studies
- RNA Research and Splicing
Universidade Estadual Paulista (Unesp)
2017-2025
Abstract Epigenetic changes, particularly histone compaction modifications, have emerged as critical regulators in the epigenetic pathway driving endothelial cell phenotype under constant exposure to laminar forces induced by blood flow. However, underlying mechanisms governing behavior this context remain poorly understood. To address knowledge gap, we conducted vitro experiments using human umbilical vein cells subjected various tensional simulating pathophysiological flow shear stress...
Abstract Whereas endothelial responses to shear stress are well‐characterized, the cell physiological effects of in smooth muscle cells (SMCs) remain largely obscure. As SMCs directly challenged by after denuding injury following procedures such as angioplasty or endarterectomy, characterization these represents an important scientific question. Hence we decided contrast cytoskeletal reorganization, epigenetic reprogramming, signaling transduction, and changes miRNA (miRs) profiles primary...
Abstract During the morphological changes occurring in osteoblast differentiation, Sonic hedgehog (Shh) plays a crucial role. While some progress has been made understanding this process, epigenetic mechanisms governing expression of Hh signaling members response to bone morphogenetic protein 7 (BMP7) osteoblasts remain poorly understood. To delve deeper into issue, we treated pre‐osteoblasts (pObs) with 100 ng/mL BMP7 for up 21 days. Initially, validated osteogenic phenotype by confirming...
Abstract Introduction: The thyroid hormone 3,3 ‘, 5 - triiodothyronine (T3) has an important role in bone physiology and metabolism, stimulating osteodifferentiation homeostasis. Although there is this evidence, little known about the synergistic events of T3 together with endocrine other players that interfere osteoblast such as Lipocalin 2 (LCN2) its hypothalamic-located MCR4 receptor. It also LCN2 interferes at a physiological level parameters food intake. Objective: To evaluate...