A5080905365- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Neurotransmitter Receptor Influence on Behavior
- Inflammatory mediators and NSAID effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Retinal Diseases and Treatments
- Pharmacogenetics and Drug Metabolism
- Sperm and Testicular Function
- Effects and risks of endocrine disrupting chemicals
- Glaucoma and retinal disorders
- Regulation of Appetite and Obesity
- Complementary and Alternative Medicine Studies
- Carcinogens and Genotoxicity Assessment
- Intestinal and Peritoneal Adhesions
- Peripheral Nerve Disorders
- Hernia repair and management
- Reproductive Biology and Fertility
- Eicosanoids and Hypertension Pharmacology
- Cancer Treatment and Pharmacology
- Nerve injury and regeneration
- Synthesis and pharmacology of benzodiazepine derivatives
- Signaling Pathways in Disease
Brown University
2014-2025
Corteva (United States)
2020-2024
Sapienza University of Rome
2011-2023
Denver School of Nursing
2022
Triangle
2022
Indianapolis Zoo
2022
Gainesville Obstetrics & Gynecology
2022
Committee on Publication Ethics
2022
Rhode Island Hospital
2017-2021
Providence College
2017-2021
Glaucoma occurs when there are imbalances between the production and drainage of eye liquid. The vast majority aqueous humor leaves through trabecular meshwork (TM). cause hypertonicity may be due to an alteration in thickness TM. In cases molecular changes that determine primary open‑angle glaucoma (POAG) unclear. However, it has been hypothesized significant increase extracellular matrix (ECM) fibrillary bands TM is associated with possible inflammatory conditions. this study tissue...
With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant phase out animal testing, interpretation of vitro assay readouts for quantitative hazard characterisation becomes more important. Physiologically based kinetic (PBK) models, which simulate fate chemicals tissues body, play essential role extrapolating effect concentrations vivo bioequivalent exposures. As PBK-based testing approaches evolve, it will become standardise PBK...
Systemic administration of morphine induced a hyperalgesic response in the hot plate test, at an extremely low dose (1–10 μg/kg). We have examined vivo whether morphine, dose, induces acute central hypernociception following activation opioid receptor-mediated PLC/PKC inositol-lipid signaling pathway. The PLC inhibitor U73122 and PKC blocker, calphostin C, dependently prevented thermal by morphine. This effect was also pretreatment with aODN against PLCβ3 2 nmol/mouse PKCγ 2–3 nmol/mouse....
Vestibular schwannomas, also known as acoustic neuromas, are benign tumors, which originate from myelin‑forming Schwann cells. They develop in the vestibular branch of eighth cranial nerve internal auditory canal or cerebellopontine angle. The clinical progression condition involves slow and progressive growth, eventually resulting brainstem compression. objective present study was to investigate expression level localization pro‑inflammatory cytokines, transforming growth factor‑β1 (TGF‑β1)...
Normal human aging and diabetes are associated with a gradual decrease of cerebral flow in the brain changes vascular architecture. Thickening capillary basement membrane microvascular fibrosis evident central nervous system elderly diabetic patients. Current findings assign primary role to endothelial dysfunction as cause (BM) thickening, while retinal alterations considered be secondary either ischemia or exudation. The aim this study was reveal any initial variations BM capillaries during...
The human population will be approximately 9.7 billion by 2050, and food security has been identified as one of the key issues facing global population. Agrochemicals are an important tool available to farmers that enable high crop yields continued access healthy foods, but average new agrochemical active ingredient takes more than ten years, 350 million dollars, 20,000 animals develop register. time, monetary, animal costs incentivize use New Approach Methodologies (NAMs) in early-stage...
Abstract Introduction Congenital diaphragmatic hernia is a major malformation occasionally found in newborns and babies. defined by the presence of an orifice diaphragm, more often to left posterolateral, that permits herniation abdominal contents into thorax. The aim this case series provide information on presentation, diagnosis outcome three patients with late-presenting congenital hernias. based clinical investigation confirmed plain X-ray films computed tomography scans. Case...
Summary Sperm RNA is a sensitive monitoring endpoint for male reproductive toxicants, and potential biomarker to assess infertility sperm quality. However, isolation of challenging procedure due the heterogeneous population cells present in ejaculate, low yield per spermatozoon, absence 18S 28S ribosomal subunits. The unique biology spermatozoa has created some uncertainty field about methods, indicating need rigorous quality control checks ensure reproducibility data generated from ....
Although alterations in micro-opioid receptor (microOR) signaling mediate excitatory effects of opiates opioid tolerance, the molecular mechanism for effect acute low dose morphine, as it relates to microOR coupling, is presently unknown. A pronounced coupling alpha subunit G inhibitory protein emerged periaqueductal gray (PAG) from mice systemically administered with morphine at a producing thermal hyperalgesia. This was abolished presence selective antagonist...
Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in aging population. The aims our studies were to identify qualitative quantitative alterations mitochondria human retinal pigment epithelium (RPE) from AMD patients controls test protective effects epithelium-derived factor (PEDF), a known neurotrophic antiangiogenic substance, against keratouveitis. Histopathological studied by means morphometry, light electron microscopy. Unexpectedly,...
Post-operative adhesions are a critical problem in pelvic and abdominal surgery despite multitude of studies dedicated to finding modalities prevent their occurrence. Ghrelin administration promotes an anti-fibrotic response surgical mouse model adhesion-induction, but the mechanisms mediating this effect have not been established. In current study, molecular that underlie anti-adhesion ghrelin were investigated. Post-surgical experimentally created C57BL/6 wild-type mice via combination...
Dupuytren's contracture (DC) is a benign fibro-proliferative disease of the hand causing fibrotic nodules and fascial cords which determine debilitating deformities fingers hands. The present study was designed to characterize pro-inflammatory cytokines growth factors involved in pathogenesis, progression recurrence this disease, order find novel targets for alternative therapies strategies controlling DC. expression detected by immunohistochemistry normal palmar fascia resected respectively...
Abstract Background Approximately half of male factor infertility cases are idiopathic, indicating a need for new methods to supplement fertility assessment. Objectives The objective this study was identify differences in the sperm transcriptomes men with different clinical status. We hypothesized that mRNA profiling could distinguish presenting assessment from proven fertile men. Materials and compared two groups participants: who presented ( n = 53, “infertility”), without history had...