A5101808656- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Urological Disorders and Treatments
- Sexual function and dysfunction studies
- Ovarian function and disorders
- Sexuality, Behavior, and Technology
- Male Reproductive Health Studies
- Pharmacology and Obesity Treatment
- Reproductive Health and Contraception
- Prostate Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- Regulation of Appetite and Obesity
- Adolescent Sexual and Reproductive Health
- Doping in Sports
- Urinary Tract Infections Management
- Pharmacological Effects and Assays
- Kidney Stones and Urolithiasis Treatments
- Assisted Reproductive Technology and Twin Pregnancy
University of Pennsylvania
2024-2025
University of Pittsburgh
2020-2025
University of Pittsburgh Medical Center
2011-2024
UPMC Health System
2021-2023
Magee-Womens Research Institute
2020
Brown University
2010-2019
Rhode Island Hospital
2009-2019
Providence College
2013-2018
American Society for Reproductive Medicine
2018
Baylor College of Medicine
2009-2012
This cross-sectional study of US patients initiating a vasectomy procedure examines the association decision-making with sociopolitical issues following Supreme Court’s repeal right to abortion.
Testosterone replacement therapy results in decreased serum gonadotropins and intratesticular testosterone, impairs spermatogenesis, leading to azoospermia 40% of patients. However, testosterone can be maintained during with co-administration low dose human chorionic gonadotropin, which may support continued spermatogenesis patients on therapy. We retrospectively reviewed the records hypogonadal men treated concomitant gonadotropin. consisted daily topical gel or weekly intramuscular...
Summary Sperm RNA is a sensitive monitoring endpoint for male reproductive toxicants, and potential biomarker to assess infertility sperm quality. However, isolation of challenging procedure due the heterogeneous population cells present in ejaculate, low yield per spermatozoon, absence 18S 28S ribosomal subunits. The unique biology spermatozoa has created some uncertainty field about methods, indicating need rigorous quality control checks ensure reproducibility data generated from ....
Abstract Background Azoospermia, characterized by the absence of sperm in ejaculate, impacts 1% men globally. Surgical approaches to retrieve from testis are effective some cases but can be invasive and expensive. Here we described a noninvasive ultrasound-guided rete (UGRT) approach testes or infuse stem cells into with azoospermia. Methods Ultrasound was used guide insertion 25-gauge hypodermic needle through base scrotum space that is contiguous all seminiferous tubules. Medium infused...
Post-operative adhesions are a critical problem in pelvic and abdominal surgery despite multitude of studies dedicated to finding modalities prevent their occurrence. Ghrelin administration promotes an anti-fibrotic response surgical mouse model adhesion-induction, but the mechanisms mediating this effect have not been established. In current study, molecular that underlie anti-adhesion ghrelin were investigated. Post-surgical experimentally created C57BL/6 wild-type mice via combination...
In this open label, single arm, dose blinded, 52-week registration phase study we evaluated the efficacy and safety of a subcutaneous testosterone enanthate auto-injector administered weekly to men with hypogonadism. A total 150 patients were initiated on 75 mg self-administered weekly. Dose adjustments made at week 7 50, or 100 based 6 trough concentration. If required, continued through extended treatment phase. Pharmacokinetic clinical laboratory parameters, emergent adverse events...
Male factors are implicated in up to 50% of couples being evaluated and treated for infertility with advanced assisted reproductive technologies. Genetic abnormalities, including sperm chromosome aneuploidy as well structural aberrations, one the major causes infertility. The use chromosome-specific DNA probes labeled fluorochromes, particularly combination multiple probes, has been used indirectly study by fluorescent situ hybridization (FISH). Clinically, this technique is also assess men...
In recent years, investigators have noted a trend toward declining proportion of male births in many industrialized nations. While men bear the sex-determining chromosome, role female partner as it pertains to fertilization or miscarriage may also alter gender ratio. We attempted determine man's secondary sex ratio (F1 generation) by directly examining chromosomes his sperm. examined our infertility clinic database for all who had undergone semen fluorescence situ hybridization (FISH)....