A5009908396- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Ion channel regulation and function
- Frailty in Older Adults
- Blood Pressure and Hypertension Studies
- Healthcare Technology and Patient Monitoring
- Infective Endocarditis Diagnosis and Management
- Cardiovascular and Diving-Related Complications
- Quality and Safety in Healthcare
- Cardiac Arrest and Resuscitation
- Connexins and lens biology
Brown University
2016-2025
Rhode Island Hospital
2018-2025
Institute for Clinical Evaluative Sciences
2023-2024
Brigham and Women's Hospital
2023
Lifespan
2018-2021
John Brown University
2020
Providence College
2018-2020
SUNY Upstate Medical University
2019
Upstate University Hospital
2019
University of Michigan
2018
The remodeling of ventricular gap junctions, as defined by changes in size, distribution, or function, is a prominent feature diseased myocardium. However, the regulation assembly and maintenance junctions remains poorly understood. To investigate N-cadherin function adult myocardium, we used floxed gene conjunction with cardiac-specific tamoxifen-inducible Cre transgene. mutant animals appeared active healthy until their sudden death approximately 2 months after deleting from heart....
Abstract Background Variance in QTc intervals can clinically lead to arrhythmias and sudden cardiac death. Pharmacotherapy including antiarrhythmic drugs (AAD) are known prolong QT interval. An insertable monitor (ICM) capable of continuously monitoring interval over a long period be useful tool for evaluating managing patients taking prolonging drugs. Purpose To analyze changes observed from real-world male female with ICM undergoing AAD loading the hospital. Methods The detection algorithm...
ABSTRACT Background Leadless pacemakers are considered a low‐risk alternative to single‐lead (SL‐PPMs). In 2021, the FDA issued warning regarding leadless because of increased morbidity and mortality from perforation. Clinical outcome data is limited. The National Readmissions Database (NRD) nationally representative annualized sample US hospitalizations that may shed insight on patient selection procedural risks pacemaker implantation. Objective Determine selection, adverse events rates...
Background: The mechanisms underlying spontaneous atrial fibrillation (AF) associated with ischemia/infarction are incompletely elucidated. Here, we investigate the AF in an ovine model of left myocardial infarction (LAMI). Methods and Results: LAMI was created by ligating branch anterior descending coronary artery. ECG loop recorders were implanted to monitor episodes. In 7 sheep, dantrolene—a ryanodine receptor blocker—was administered vivo during 8-day observation period (LAMI-D, 2.5...
Atrioventricular block requiring permanent pacemaker (PPM) implantation is a common complication of transcatheter aortic valve replacement (TAVR). The mechanism atrioventricular (AV) during TAVR not fully understood, but it may be due to the mechanical stress deployment, resulting in possible injury nearby compact AV node. Aortic calcification (AVC) worsen this condition and has been associated with an increased risk for post-TAVR PPM implantation. We performed retrospective analysis...
Abstract Background QT interval prolongation is associated with the development of potentially lethal cardiac arrhythmias. An implantable monitor (ICM) capable longitudinal monitoring may allow for mobile assessment dynamic changes in and assist predicting long term cardiotoxicity. Objective Determine feasibility continuous QTc patients ICM hospitalized antiarrhythmic drug loading. Methods The previously described detection algorithm an determines every beat thus providing long-term trends....
Abstract Background Randomized clinical trial data have demonstrated catheter ablation (CA) as a viable treatment modality for atrial fibrillation (AF). Patients with heart failure (HF) undergoing AF CA appear to derive improvements in quality of life and mortality compared those treated medical therapy (MT). Contemporary national on 30‐day readmissions after MT among patients HF are lacking. Methods From the 2016 Nationwide Readmissions Databases, 749 776 (weighted estimate: 1 421 673) were...
Abstract Patients with epilepsy suffer from a higher mortality rate than the general population, portion of which is not due to itself or comorbid conditions. Sudden unexpected death in (SUDEP) common but poorly understood cause patients intractable and often afflicts younger patients. The pathophysiology SUDEP defined does appear be related prolonged seizure activity resultant injury. Interestingly, subset confirmed long QT syndrome (LQTS) present phenotype may have concurrent epilepsy. In...
Abstract Background Cardiac implantable electronic devices (CIED) are sometimes required after alcohol septal ablation (ASA) for hypertrophic cardiomyopathy (HCM). The primary objectives of this study were to characterize the incidence, timing, and predictors CIED placement ASA HCM. Methods Patients identified from 2010–2015 Nationwide Readmissions Databases. Incidence, timing independent placement, as well 30‐day readmission rates examined. Results There 1296 patients (national estimate =...
The overall incidence of Out-of-hospital Cardiac Arrest (OHCA) is decreasing worldwide due to emergency responses, but there are gender and racial differences in the OHCA, which remain under investigation. Our aim was identify incidence, gender, disparities patients admitted with OHCA. National Inpatient Sample Database one largest all-payer inpatient database. It queried 18 years or older who were hospitalized principal diagnosis There a total 85,988 discharged classified as OHCA using...
The QT interval is of high clinical value as prolongation can lead to Torsades de Pointes (TdP) and sudden cardiac death. Insertable monitors (ICMs) have the capability detecting both absolute relative changes in interval. In order determine feasibility for long-term ICM based detection, we developed validated an algorithm continuous monitoring patients with ICM.The detection algorithm, intended use ICMs, designed detect T-waves beat-to-beat QTc intervals. was using real-world data....