A5046114460- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Click Chemistry and Applications
- Electrochemical Analysis and Applications
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Trace Elements in Health
- Spectroscopy and Chemometric Analyses
- Polydiacetylene-based materials and applications
- DNA and Nucleic Acid Chemistry
- Amino Acid Enzymes and Metabolism
- Metabolomics and Mass Spectrometry Studies
- SARS-CoV-2 and COVID-19 Research
- Ferrocene Chemistry and Applications
- Infectious Encephalopathies and Encephalitis
- Luminescence and Fluorescent Materials
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Monoclonal and Polyclonal Antibodies Research
- Supramolecular Chemistry and Complexes
- Biotin and Related Studies
- Medical Imaging Techniques and Applications
The University of Sydney
2017-2024
Australian Research Council
2021
Copper participates in a range of critical functions the nervous system and human brain. Disturbances brain copper content is strongly associated with neurological diseases. For example, changes level distribution are reported neuroblastoma, Alzheimer's disease, Lewy body disorders, such as Parkinson disease dementia bodies (DLB). There need for more sensitive techniques to measure intracellular levels have better understanding role homeostasis neuronal disorders. Here, we report...
Synthetic anion transporters that mediate electroneutral (H+/Cl–) transport have demonstrated anti-cancer activity due to their ability disrupt subcellular homeostatic environments. Elucidation of the cell death mechanism revealed transporters’ neutralize lysosomal pH gradients and inhibit autophagy. However, effect on other compartments is unknown. Herein, we disclose first targeted anionophores accumulate in various membrane bound organelles bias natural propensity depolarize lysosomes....
Abstract The COVID‐19 pandemic has had a devastating impact on global health, highlighting the need to understand how SARS‐CoV‐2 virus damages lungs in order develop effective treatments. Recent research shown that patients with experience severe oxidative damage various biomolecules. We propose overproduction of reactive oxygen species (ROS) infection involves an interaction between copper ions and virus‘s spike protein. tested two peptide fragments, Ac‐ELDKYFKNH‐NH 2 (L1) Ac‐WSHPQFEK‐NH...
Fluorescent probes for biological imaging have revealed much about the functions of biomolecules in health and disease. Fluorogenic probes, which are fluorescent only upon a bioorthogonal reaction with specific partner, particularly advantageous as they ensure that signals observed arise solely from intended target. In this work, we report first series naphthalimide tetrazines fluorogenic labelling. We establish all these compounds can be used through photophysical, analytical studies. The...
Biochemical changes in specific organelles underpin cellular function, and studying these is crucial to understand health disease. Fluorescent probes have become important biosensing imaging tools as they can be targeted detect their chemical environment. However, the sensing capacity of fluorescent highly often limited a single analyte interest. A novel approach combine sensors with vibrational spectroscopic techniques; latter provides comprehensive map relative biochemical distributions...
Synthetic anion transporters that mediate electroneutral (H+/Cl-) transport have demonstrated anti-cancer activity due to their ability disrupt subcellular homeostasis. Elucidation of the cell death mechanism revealed transporters’ neutralise lysosomal pH gradients and inhibit autophagy. However, effect on other compartments is unknown. Herein, we disclose first targeted anionophores accumulate in various membrane bound organelles bias natural propensity depolarise lysosomes. The series...
Imaging with multiple modalities can maximise the information gained from analysis of a single sample. probes for optical fluorescence and X-ray microscopy based on brominated 4-amino-1,8-naphthalimide BODIPY scaffolds have been successfully designed synthesised. Herein we show that these prototype probes, each scaffolds, be imaged in two different cancer cell lines, respective signals are well correlated images.
Copper participates in a range of critical functions the nervous system human brain. Disturbances brain copper content is strongly associated with neurological disease. For example, changes level and distribution are reported neuroblastoma, Alzheimer's disease Lewy body disorders. There need for more sensitive techniques to measure intracellular levels have better understanding role homeostasis neuronal Here we report reaction-based near-infrared (NIR) ratiometric fluorescent probe CyCu1...