A5035227963- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Lipid Membrane Structure and Behavior
- Neuroscience and Neuropharmacology Research
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
- Chemical Reaction Mechanisms
- Drug Transport and Resistance Mechanisms
- Supramolecular Self-Assembly in Materials
- Amino Acid Enzymes and Metabolism
- Ion channel regulation and function
- DNA and Nucleic Acid Chemistry
The University of Sydney
2021-2025
University of Technology Sydney
2023-2024
A five-membered central scaffold was used to develop a series of anion receptors. The library perturbed liposomal pH gradients through H + /Cl − transmembrane transport and elicited variety cytotoxicities against normal cancerous cell lines.
Synthetic anion transporters that mediate electroneutral (H+/Cl–) transport have demonstrated anti-cancer activity due to their ability disrupt subcellular homeostatic environments. Elucidation of the cell death mechanism revealed transporters’ neutralize lysosomal pH gradients and inhibit autophagy. However, effect on other compartments is unknown. Herein, we disclose first targeted anionophores accumulate in various membrane bound organelles bias natural propensity depolarize lysosomes....
Designing molecular receptors that bind anions in water is a significant challenge, and an even greater difficulty lies using these to remove from without resorting the hazardous liquid–liquid extraction approach. We here demonstrate effective synthetically simple strategy toward goals by exploiting ion-pair assembly of macrocycles. Our anion binding ensemble consists octa-chloro tetra-urea macrocyclic receptor (ClTU), which forms water-dispersible aggregates, tetra-cationic fluorescent dye...
A potent squaramide-based anion transporter was used to evaluate how vesicles prepared with tailored lipid compositions, which mimic organelle membranes, can impact transmembrane transport.
Synthetic anion transporters that mediate electroneutral (H+/Cl-) transport have demonstrated anti-cancer activity due to their ability disrupt subcellular homeostasis. Elucidation of the cell death mechanism revealed transporters’ neutralise lysosomal pH gradients and inhibit autophagy. However, effect on other compartments is unknown. Herein, we disclose first targeted anionophores accumulate in various membrane bound organelles bias natural propensity depolarise lysosomes. The series...
Abstract Using the chemical versatility of benzo[ b ]thiophene motif, an extensive library 24 (thio)urea receptors, with different binding properties and lipophilicities, was prepared included α,α‐, α,β‐, β,β‐, β,γ‐, α,γ‐, γ,γ‐benzo[ positional isomers, as well β‐ or γ‐benzo[ ]thiophene‐based molecules decorated aliphatic chains aryl moieties fluorination degrees. 1 H NMR titrations, X‐ray crystallographic studies, DFT calculations were used to study chloride affinities between receptors...