A5104305527- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Asymmetric Hydrogenation and Catalysis
- Molecular Sensors and Ion Detection
- DNA and Nucleic Acid Chemistry
- Asymmetric Synthesis and Catalysis
- Luminescence and Fluorescent Materials
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Natural product bioactivities and synthesis
- Synthesis of Organic Compounds
- Advanced Chemical Sensor Technologies
- Carbon and Quantum Dots Applications
- Multicomponent Synthesis of Heterocycles
- Microwave-Assisted Synthesis and Applications
- Chemical Synthesis and Analysis
- Phytochemistry and Biological Activities
- Microfluidic and Capillary Electrophoresis Applications
- E-commerce and Technology Innovations
- Chemical Reaction Mechanisms
- Synthesis and Reactions of Organic Compounds
Guizhou Minzu University
2015-2025
Southern Medical University
2022-2025
Qingdao University
2023-2024
Qingdao Municipal Hospital
2023-2024
Shaanxi University of Science and Technology
2020-2023
Geely (China)
2023
Central South University
2023
Fuzhou Maternity and Child Health Care Hospital
2023
Shenzhen University
2018
Fujian Agriculture and Forestry University
2017
Surface-attached peptide nucleic acids (PNA) are shown to retain their unique and efficient hybridization properties, reported in solution studies. PNA recognition layers thus offer significant advantages for sequence-specific DNA biosensors, compared counterparts. These include significantly higher sensitivity specificity (including greater discrimination against single-base mismatches), faster at room elevated temperatures, minimal dependence on ionic strength, use of shorter (10−15-mer)...
An electrochemical biosensor for the detection of short DNA sequences related to human immunodeficiency virus type 1 (HIV-1) is described. The sensor relies on immobilization and hybridization 21- or 42-mer single-stranded oligonucleotide from HIV-1 U5 long terminal repeat (LTR) sequence at carbon paste strip electrodes. extent between complementary determined by enhancement chronopotentiometric peak Co(phen)3(3+) indicator. Numerous factors affecting probe immobilization, target...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrace Measurements of RNA by Potentiometric Stripping Analysis at Carbon Paste ElectrodesJoseph. Wang, Xiaohua. Cai, Jianyan. Colleen. Jonsson, and Emil. PalecekCite this: Anal. Chem. 1995, 67, 22, 4065–4070Publication Date (Print):November 15, 1995Publication History Published online1 May 2002Published inissue 15 November 1995https://pubs.acs.org/doi/10.1021/ac00118a006https://doi.org/10.1021/ac00118a006research-articleACS PublicationsRequest...
A quartz crystal microbalance DNA hybridization biosensor, based on thiol-derivatized peptide nucleic acid (PNA) probes, offers unusual in situ differentiation of single-base mismatches. large excess a mismatch oligonucleotide has no effect the frequency response target. Such remarkable distinction between perfect matches and mismatches is illustrated by detection common mutation p53 gene. The greater specificity new mass-sensitive indicatorless device over those analogous PNA-based carbon...
A double-stranded (ds) DNA-coated carbon paste electrode is employed as a remarkably sensitive biosensor for the detection of hydrazine compounds. The sensor relies on monitoring changes in intrinsic anodic response surface-confined DNA resulting from its interaction with compounds and requires no label or indicator. Short reaction times (1−10 min) are sufficient part-per-billion levels different hydrazines. Applicability to untreated natural water samples illustrated. mechanism discussed,...
A new electrochemical biosensing strategy has been developed for trace measurements of toxic aromatic amine compounds. The device relies on the intercalative collection amines onto immobilized dsDNA layer followed by potentiometric stripping quantitation accumulated species. enhanced sensitivity, accrued from DNA process, is coupled to selectivity dimensions provided structural requirements such binding. extent and rate accumulation are strongly dependent upon structure Having amino...
Carbon dioxide is the ideal one-carbon source for organic synthesis because of its abundance, lack toxicity, and potential as a renewable resource, but limited by high stability low reactivity. The carboxylation carbon nucleophiles with to form new carbon–carbon bonds therefore an attractive method carboxylic acids derivatives, which are in turn valuable products. Thus, designing mild methods catalytically activate challenge that both academic practical importance. This review focused on...
Selective partial C–Cl bond reduction represents an important strategy for the construction of valuable chlorine-containing skeletons.
Abstract Potentiometric stripping analysis is employed for highly sensitive measurements of single‐stranded DNA at carbon paste electrodes. Electrochemical (oxidative) pretreatment used to condition the surface prior accumulation process. The low background response potentiometric mode offers convenient quantitation nanogram quantities DNA. Experimental variables and measurement procedures are explored optimized. Results also reported levels long terminal repeat (LTR) from human leukemia...
The asymmetric Mannich reaction is one of the most useful carbon-carbon bond forming reactions for synthesis chiral molecules containing nitrogen.The resulting β-amino carbonyl compounds are valuable synthons in preparation many natural products with biological properties.This review provides an overview recent years under different organocatalytic systems, including: amines, bifunctional thiourea, Brønsted acids and other systems.
The direct C-H bond functionalization has been one of the most active research fields in organic chemistry not only due to significance basic studies inert but also step economy feature potential synthetic application.In past decades, transition-metalcatalyzed and selective bonds emerged as a straightforward environmentally friendly tool, which is long-standing goal that continues drive discovery synthesis.The precious late transition metals have proved play key roles facilitate highly...
The Strecker reaction is one of the most attractive methods for synthesis α-amino acids and other bioactive compounds including natural products.The asymmetric represents a simple efficient method optically pure acid derivatives, nucleic acids, various nitrogen sulfur containing heterocycles pharmaceuticals.Over past several decades, considerable effort has been devoted towards development reactions.This review provides an overview recent reactions, from diastereoselective reactions...