A5046475529- Metalloenzymes and iron-sulfur proteins
- Mitochondrial Function and Pathology
- Trace Elements in Health
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Metabolism and Genetic Disorders
- Fungal and yeast genetics research
- ATP Synthase and ATPases Research
- Metal-Catalyzed Oxygenation Mechanisms
- Photosynthetic Processes and Mechanisms
- Iron Metabolism and Disorders
- Cancer-related gene regulation
- Heat shock proteins research
- Porphyrin Metabolism and Disorders
- Folate and B Vitamins Research
- Bacterial Genetics and Biotechnology
- Enzyme Structure and Function
- Redox biology and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- Microbial Fuel Cells and Bioremediation
- DNA and Nucleic Acid Chemistry
- Electrocatalysts for Energy Conversion
- Biochemical and Molecular Research
- Nutrition, Genetics, and Disease
Philipps University of Marburg
2015-2024
Loewe Center for Synthetic Microbiology
2014-2024
Institut du Cerveau
2015
Inserm
2015
Sorbonne Université
2015
Centre National de la Recherche Scientifique
2015
Ghent University Hospital
2013-2015
Hadassah Medical Center
2015
Max Planck Institute for Terrestrial Microbiology
2008-2014
Max Planck Society
2008-2013
Cu,Zn-superoxide dismutase (SOD1) is an abundant, largely cytosolic enzyme that scavenges superoxide anions. The biological role of SOD1 somewhat controversial because thought to arise from the mitochondria where a second SOD (manganese SOD) already resides. Using bakers' yeast as model, we demonstrate Cu,Zn-SOD1 helps protect oxidative damage, sod1Δ mutants show elevated protein carbonyls in this organelle. In accordance with connection mitochondria, fraction active localizes within...
Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid hormones in adrenal glands. As a member [2Fe-2S] cluster-containing ferredoxin family, Fdx1 reduces mitochondrial cytochrome P450 enzymes, which then catalyze; e.g., conversion cholesterol to pregnenolone, aldosterone, and cortisol. The high protein sequence similarity between its yeast homologue (Yah1) suggested that Fdx1, like Yah1, may be involved biosynthesis heme A Fe/S clusters, two versatile...
We report on ten individuals with a fatal infantile encephalopathy and/or pulmonary hypertension, leading to death before the age of 15 months. Hyperglycinemia and lactic acidosis were common findings. Glycine cleavage system pyruvate dehydrogenase complex (PDHC) activities low. Homozygosity mapping revealed perfectly overlapping homozygous region 1.24 Mb corresponding chromosome 2 led identification missense mutation (c.622G>T) in NFU1, which encodes conserved protein suggested participate...
MMS19 Joins the CIA Iron-sulfur (Fe-S) proteins play a critical role in cell metabolism and particularly DNA repair replication. Mutants eukaryotic gene are sensitive to damaging agents, suggesting that it is involved repair, but mutations can also have other wide-ranging effects on (see Perspective by Gottschling ). Now, Stehling et al. (p. 195 , published online 7 June) Gari 243 show both yeast humans, functions as part of cytosolic Fe-S protein assembly (CIA) machinery. The specialized...
Crossing the Membrane Adenosine triphosphate (ATP)–binding cassette (ABC) transporters couple ATP hydrolysis to translocation of a wide variety substrates across cell membranes. Srinivasan et al. (p. 1137 ) describe structure yeast mitochondrial transporter involved in Fe-S protein biogenesis. The reveals bound glutathione, which suggests that glutathione is part translocated substrate. J. Y. Lee 1133 bacterial ABC confers protection against silver and mercury. This also binds derivatives....
Iron-sulfur (Fe/S) clusters are essential protein cofactors crucial for many cellular functions including DNA maintenance, translation, and energy conversion. De novo Fe/S cluster synthesis occurs on the mitochondrial scaffold ISCU requires cysteine desulfurase NFS1, ferredoxin, frataxin, small factors ISD11 ACP (acyl carrier protein). Both mechanism of function ISD11-ACP poorly understood. Here, we present crystal structures three different NFS1-ISD11-ACP complexes with without ISCU, use...