A5008301054- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Selenium in Biological Systems
- Trace Elements in Health
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heavy Metal Exposure and Toxicity
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
Luton and Dunstable Hospital
2023
University of Edinburgh
2007
Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in its pathogenesis is unknown. To identify risk variants, we conducted a GWAS 3,212 patients with psoriasis, whom 88 developed Two lead SNPs reached genome-wide significance (P ≤ 5 × 10−8) association eczema: rs192705221 (near UNC5B, P = 9.52 10−10) and rs72925168 (within SLC1A2, 1.66 10−9). Genome-wide significant from published were used to generate polygenic scores (PRSs) atopic eczema, general...
The identification of robust endotypes-disease subgroups clinical relevance-is fundamental to stratified medicine. We hypothesized that HLA-C∗06:02 status, the major genetic determinant psoriasis, defines a psoriasis endotype relevance. Using two United Kingdom-based cross-sectional datasets-an observational severe-psoriasis study (Biomarkers Systemic Treatment Outcomes in Psoriasis; n = 3,767) and large population-based bioresource (UK Biobank, including 5,519 individuals with psoriasis)-we...
The mechanisms whereby narrowband ultraviolet B (UVB) (311-313 nm, TL01) phototherapy are effective in psoriasis may differ from those occurring broadband UVB phototherapy. In the present study, changes epidermal cells as a result of TL01 therapy were assessed skin patients with psoriasis. non-lesional five subjects plaque was biopsied before and after series 12 whole-body treatments. Following appropriate staining sections, numbers p53-positive keratinocytes, sunburn Langerhans epidermis...
Selenium (Se) has protective properties against ultraviolet (UV)‐induced changes in skin cells vitro but little is known about such activity human subjects. In the present study, seven patients with psoriasis ingested 400 μg of sodium selenite daily during a 4 week course whole‐body narrow‐band UVB (TL01) therapy while six more patients, similarly irradiated, placebo. Skin biopsies, collected at start and end phototherapy were analysed for phosphorylated p53, Fas, Bcl‐2, Bax oxidized...
Abstract A 69-year-old woman was referred to the dermatology department for evaluation of multiple widespread subcutaneous lesions involving neck, torso and limbs. These lesions, initially diagnosed in community as lipomas, had been slowly progressing size number 3 years. She remained systemically well. Her only medical history essential thrombocythaemia. took no regular medication. On examination, there were appreciated on palpation with overlying epidermal change. The patient experiencing...