A5030695415- Inflammatory Bowel Disease
- Autoimmune and Inflammatory Disorders
- Microscopic Colitis
- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Gastrointestinal disorders and treatments
- Congenital gastrointestinal and neural anomalies
- Intestinal Malrotation and Obstruction Disorders
- Human Health and Disease
- Congenital Diaphragmatic Hernia Studies
- Protein Kinase Regulation and GTPase Signaling
- Phenothiazines and Benzothiazines Synthesis and Activities
- Digestive system and related health
- Colorectal and Anal Carcinomas
- Cellular Mechanics and Interactions
- Neuroscience and Neuropharmacology Research
- Diabetes and associated disorders
- Nuclear Structure and Function
- Enhanced Recovery After Surgery
- Multiple and Secondary Primary Cancers
- Pregnancy-related medical research
- Therapeutic Uses of Natural Elements
- Intestinal and Peritoneal Adhesions
- Synthesis and Biological Evaluation
- Neuroendocrine Tumor Research Advances
Pirogov Russian National Research Medical University
2019-2025
Ministry of Health of the Russian Federation
2019-2025
National Medical and Surgical Center named after N.I. Pirogov
2025
Center for Children
2024
Russian Children's Clinical Hospital
2010-2024
City Clinical Hospital
2017-2019
Moscow State University of Medicine and Dentistry
2018
City Children's Hospital No. 22
2018
Institute of Experimental Cardiology
2006-2010
Russian Academy of Sciences
2002
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Inflammatory myofibroblastic tumor is a rare type of mesenchymal tumor, predominantly benign but with intermediate malignant potential. This article presents clinical case successful surgical treatment child an extremely localization inflammatory in the rectum (the fourth reported worldwide), initially misdiagnosed as Crohn disease. A 4-year-old girl presented diarrhea, blood, and mucus stool. Examination revealed ulcerative pancolitis rectal mass, presumed to be origin. Treatment mesalazine...
The final version of the draft protocol for diagnosis and treatment Crohn’s disease in children, developed by experts Russian Society Pediatric Gastroenterology, Hepatology Nutrition, is presented article. This project has been repeatedly discussed pediatric gastroenterologists - specialists study IBD children during round tables at XXV-th XXVI-th Congres Gastroenterologists Russia and, after approval, will be form clinical recommendations.
From the beginning of 2000s, there has been a significant increase in incidence inflammatory bowel diseases (IBD) and primary immunodeficiency disorders (PIDs) adults children many countries around world. The aim review is to summarize state-of-the-art on diverse clinical types PIDs with gastrointestinal manifestations their differential diagnostic algorithms.
 Atypical “blunted” are challenging for timely diagnosis. Some involvement also difficult differentiate classical IBDs....
KRP (kinase-related protein), also known as telokin, has been proposed to inhibit smooth muscle contractility by inhibiting the phosphorylation of rMLC (regulatory myosin light chain) Ca2+-activated MLCK (myosin chain kinase). Using phosphatase inhibitor microcystin, we show in present study that inhibits Ca2+-independent and contraction mediated novel kinases. Incubating KRP-depleted Triton-skinned taenia coli with microcystin at pCa>8 induced a slow reaching 90% maximal force (Fmax) pCa...
AIM: to establish the consensus on controversial issues of surgery for Сrohn’s disease by Delphi method. METHODS: a cross-sectional study was conducted 62 experts voted intramural and anonymous (31.03.23). 5 statements from current edition clinical guidelines were selected correction working group further voting [2]. Based practical experience literature data, 3 new created also. Statements that do not reach required level agreement (80% or more) will be subjected Round 2 RESULTS: all took...
The article presents the features of Crohn’s disease in childhood and adolescence, modern classification disease, indications for surgical treatment algorithm therapeutic tactics complicated course disease. variants chronic complications are demonstrated. Surgery severe can be regarded not only as an aid but also a good alternative to conservative treatment.
Ulcerative colitis is recurrent inflammatory disorder of the large intestine characterized by continuous expansion bowel involvement, from rectum to proximal parts. Despite certain similar sign with adults, ulcerative in children has a number special features and distinctions disease course therapy response, therefore such peculiarities should be considered while choosing management strategy. In 2012 European Crohn’s Colitis Organisation Society for Pediatric Gastroenterology, Hepatology...
There is presented the clinical report of diagnosis and surgical treatment such rare malformation as tubular duplication small intestine in an 11-years girl. Clinical manifestations were intense abdominal pain intestinal bleeding unknown origin. Video capsule enteroscopy (VCE) made it possible to identify pathological area determine its location. The article presents modern ideas about intestine. are indicated diagnostic methods signs allow suspecting this malformation. possibilities...
AIM: to identify the genotype-phenotype correlation in children with familial adenomatous polyposis (FAP) and assess risk of surgery. PATIENTS AND METODS: a retrospective study included FAP from January 2000 December 2023. For analysis they were divided two groups (“severe” “non-severe” genotype) according results genetics. RESULTS: forty-two patients 36 families study. Statistical revealed that mean age at time surgery was significantly different 13 ± 4 years “severe” genotype group vs. 16...
Currently, laparoscopic operations are widely used in pediatric surgical practice (both emergency and elective surgery). Separately, it is worth noting the difficulty of performing reconstructive interventions using endovideosurgical technologies coloproctology surgery inflammatory bowel diseases (Crohn's disease, ulcerative colitis, etc.). Objective. Present experience patients with Crohn's disease. Patients methods. For period from 2005 to 2023, 64 children various forms disease on basis...
BACKGROUND: Crohns disease is an incurable progressive condition of the gastrointestinal tract in which up to 90% patients undergo one or more surgical interventions during their lifetime. Despite active development and implementation new techniques for treatment disease, incidence postoperative complications remains high, i.e., 25%30%. Until now, influence various factors on outcomes choice differentiated children with remain highly debatable.
 AIMS: To study identify possible risk...
Gastrointestinal tract (GIT) duplication is a rare congenital anomaly with an incidence of about 1 in 4,500 newborns. Duplication the intestine, as rule, diagnosed at 2–3 years, however, cases this pathology being detected patients any age are described. GIT can be asymptomatic or when massive intestinal bleeding, perforation, obstruction due to intussusception volvulus, and even malignancy doubled section occur. The characteristic signs intestine well-developed muscular membrane, general...
This review aims to summarize the existing literature on irritable bowel syndrome (IBS) in children and discuss evolution of definitions diagnostic criteria according Rome IV Criteria issued 2016. The article also covers main theories IBS pathogenesis, including role surgical interventions changes intestinal microbiota. There is an overview current therapeutic approaches used for treatment accordance with variety etiopathogenetic factors. It has been shown that use probiotics,...