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A5117576713The SOS response is among the most conserved pathways that promote acquisition of antibiotic resistance in bacteria. This study aimed to identify and characterize small-molecule inhibitors system opportunistic pathogen Pseudomonas aeruginosa . A library 318 drug-like compounds was screened for inhibition RecA-induced LexA autoproteolysis, a key step activation. One hit compound, 3-(2-sulfanylanilino)propanoic acid, showed dose-dependent with an IC50 mid-micromolar range. Differential...
10.1101/2025.05.13.651886
preprint
EN
cc-by-nc-nd
bioRxiv (Cold Spring Harbor Laboratory)
2025-05-15
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