A5013743861- Sleep and related disorders
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Sleep and Work-Related Fatigue
- Children's Physical and Motor Development
- Circadian rhythm and melatonin
- COVID-19 and Mental Health
- Neuroscience and Neuropharmacology Research
- Child Nutrition and Feeding Issues
- Infant Development and Preterm Care
- EEG and Brain-Computer Interfaces
- Mental Health Research Topics
- Family and Disability Support Research
- Early Childhood Education and Development
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Maternal Mental Health During Pregnancy and Postpartum
- Congenital heart defects research
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Suicide and Self-Harm Studies
Brown University
2016-2025
Bradley Hospital
2016-2025
Providence College
2016-2025
John Brown University
2022
Erasmus MC
2020
Miriam Hospital
2019
University of California, Berkeley
2011-2017
Science Research Laboratory
2016
Cognitive Neuroimaging Lab
2011-2013
Ample evidence supports a role for sleep in the offline consolidation of memory. However, circumstances exist where forgetting can be as critical remembering, both daily life and clinically. Using directed paradigm, here, we investigate impact explicit cue instruction during learning, prior to sleep, on subsequent remembering memory, after sleep. We demonstrate that relative time awake, selectively ignore facilitation items previously cued forgotten, yet preferentially enhance recall...
A hallmark feature of cognitive aging is a decline in the ability to form new memories. Parallel these impairments are marked disruptions sleep physiology. Despite recent evidence young adults establishing role for spindles restoring hippocampal-dependent memory formation, possibility that disrupted physiology contributes age-related learning remains unknown. Here, we demonstrate reduced prefrontal by over 40% older statistically mediates effects old age on next day episodic learning, such...
Facial expressions represent one of the most salient cues in our environment. They communicate affective state and intent an individual and, if interpreted correctly, adaptively influence behavior others return. Processing such stimuli is known to require reciprocal signaling between central viscerosensory brain regions peripheral-autonomic body systems, culminating accurate emotion discrimination. Despite emerging links sleep regulation, impact loss on discrimination complex social emotions...
Anticipation is an adaptive process, aiding preparatory responses to potentially threatening events. However, excessive anticipatory responding and associated hyper-reactivity in the amygdala insula are integral anxiety disorders. Despite co-occurrence of sleep disruption disorders, impact loss on affective brain mechanisms, interaction with anxiety, remains unknown. Here, we demonstrate that amplifies preemptive anterior during anticipation humans, especially for cues high predictive...
As critical as waking brain function is to learning and memory, an established literature now describes equally important yet complementary role for sleep in information processing. This overview examines the specific contribution of human hippocampal memory processing; both detriments caused by a lack sleep, conversely, proactive benefits that develop following presence sleep. First, before discussed, preparing hippocampus initial encoding. Second, after considered, modulating post-encoding...
Sleep deprivation impairs the formation of new memories. However, marked interindividual variability exists in degree to which sleep loss compromises learning, mechanistic reasons for are unclear. Furthermore, physiological processes restore learning ability following similarly unknown. Here, we demonstrate that structural morphology human hippocampal subfields represents one factor determining vulnerability (and conversely, resilience) impact on memory formation. Moreover, this same measure...
Sleep spindles promote the consolidation of motor skill memory in young adults. Older adults, however, exhibit impoverished sleep-dependent consolidation. The underlying pathophysiological mechanism(s) explaining why older adults fails to benefit from sleep remains unclear. Here, we demonstrate that male and female show overnight relative with extent impairment being associated degree reduced frontal fast spindle density. magnitude loss was predicted by white matter integrity throughout...
Insufficient sleep is a known trigger of anxiety. Nevertheless, not everyone experiences these effects to the same extent. One determining factor sex, wherein women experience greater anxiogenic impact in response loss than men. However, underlying brain mechanism(s) governing this sleep-loss-induced anxiety increase, including markedly different reaction and men, unclear. Here, we tested hypothesis that structural morphology discrete network emotion-relevant regions represents one such...
Abstract Study Objectives To examine associations among instructional approaches, school start times, and sleep during the COVID-19 pandemic in a large, nationwide sample of U.S. adolescents. Methods Cross-sectional, anonymous self-report survey study community-dwelling adolescents (grades 6–12), recruited through social media outlets October/November 2020. Participants reported on approach (in-person, online/synchronous, online/asynchronous) for each weekday (past week), times (in-person or...
Alcohol consumption before sleep decreases latency, explaining the common use of alcohol as a aid. The full impact on architecture is not well understood, particularly potential cumulative effects presleep across consecutive nights. Here, we describe three Thirty adult participants took part in crossover, within-participants study consisting two sets nights in-lab polysomnography. For each series nights, drank one beverages: mixer only or plus (targeting BrAC 0.08 mg/L), ending 1 hour lights...
Attention deficit hyperactivity disorder (ADHD) is associated with deficits in motor learning and sleep. In healthy adults, overnight improvements skills are sleep spindle activity the electroencephalogram (EEG). This association poorly characterized children, particularly pediatric ADHD. Polysomnographic was monitored 7 children ADHD 14 typically developing controls. All were trained on a validated sequence task (MST) evening retesting following morning. Analyses focused MST precision...
Abstract Introduction Depression and insomnia are bidirectionally related. It is hypothesized that fronto-limbic brain function, specifically the amygdala medial prefrontal cortex (mPFC), links sleep mood disturbances represents targets of insomnia-related emotional dysfunction. A primary aim this first-phase a two-phase mechanistic clinical trial was to test whether treatment engages these affective circuits. Secondarily, we examined treatment-related changes in emotion outcomes their...
Abstract Introduction Sleep problems are prevalent in pediatric anxiety and related disorders (ARD), affecting nearly 90% of patients. Nevertheless, subjective sleep complaints routinely demonstrate poor agreement with objective patterns derived from either actigraphy or polysomnography non-psychiatric samples. The aim this submission is to examine the relationship between metrics quality youth moderate-to-severe ARD. Methods We conducted a multi-method study involving clinical sample...
Abstract Introduction Estimating sleep from actigraphy is a challenge in psychiatric populations where criteria may be susceptible to altered physical activity. Expert-consensus procedures introduce bias. Alternative scoring protocols resolve ambiguities, avoid the need for consensus, and increase reproducibility. This study compared two treatment-seeking sample of adolescents with ARD. Methods Thirty-six (24 F; ages 13-17yrs [m±sd: 15±1.7yrs]) diagnosed ARD wore patch activity monitor on...
Abstract Introduction Sleep disturbances are common among cancer survivors. While increased physical activity (PA) is known to improve sleep in the general population, it unclear whether exercise can The purpose of this study was examine self-reported problems survivors and explore parameters change following a 12-week PA program. Methods 23 adults (82.6% female; Age: 54.4 ± 7.9 years; BMI: 33.0 9.4; duration since end treatment: 665.0 728.5 days) who reported being physically inactive were...