Peritoneal dissemination of tumor has high mortality and is associated with the loss epithelial features, acquisition motile mesenchymal morphology characteristics, invasive properties by cells. Melatonin an endogenously produced molecule in all plant species that known to exert antitumor activity, but date, its underlying mechanisms antiperitoneal metastasis efficacy not well defined. This study determined potential melatonin vivo assessed association inhibition epithelial-to-mesenchymal...

Background Honokiol, a small-molecular weight natural product, has previously been reported to activate apoptosis and inhibit gastric tumorigenesis. Whether honokiol inhibits the angiogenesis metastasis of cancer cells remains unknown. Methodology/Principal Findings We tested effects on angiogenic activity peritoneal dissemination using in vivo, ex vivo vitro assay systems. The signaling responses human cells, umbilical vascular endothelial (HUVECs), isolated tumors were detected analyzed....

Honokiol is known to suppress the growth of cancer cells; however, date, its antiperitoneal dissemination effects have not been studied in an orthotopic mouse model. In present study, we evaluated potential model and assessed associations with tumor factor-β1 (TGFβ1) cells stimulated by a carcinogen, N -methyl- ′-nitro- -nitrosoguanidine (MNNG). Our results demonstrate that growth, peritoneal peritoneum or organ metastasis orthotopically implanted MKN45 were significantly decreased...

// De-Wei Lai 1 , Shing-Hwa Liu 2,* Anna Isabella Karlsson 3 Wen-Jane Lee 4,* Keh-Bin Wang 5 Yi-Ching Chen Chin-Chang Shen 6 Sheng-Mao Wu Chia-Yu Hsing-Ru Tien Yen-Chun Peng 7 Yee-Jee Jan 8 Te-Hsin Chao 9 Keng-Hsin Lan 10,11 Jack L. Arbiser and Meei-Ling Sheu 1,4,12 Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan 2 Toxicology, College Medicine, Taipei, Department Dermatology, Emory University School Winship Cancer Institute, Atlanta Veterans Administration...

In this study, we studied the therapeutic effectiveness of percutaneous drainage with antibiotics and need for an interval appendectomy treating appendiceal abscess in children a research-oriented dataset released by Bureau National Health Insurance Taiwan through Collaboration Center Information Application (CCHIA).We identified 1225 patients under 18 years age who had non-surgical treatment between 2007 2012 CCHIA dataset. The included or alone. We also analyzed data patient's baseline...

Histone deacetylase (HDAC) inhibitors (HDIs) can modulate the epithelial-mesenchymal transition (EMT) progression and inhibit migration invasion of cancer cells. Emerging as a novel class anti-cancer drugs, HDIs are attracted much attention in field drug discovery. This study aimed to discern underlying mechanisms Honokiol preventing metastatic dissemination gastric cells by inhibiting HDAC3 activity/expression.Clinical pathological analysis was performed determine relationship between tumor...

Abstract Background Hepatocellular carcinoma (HCC) is often diagnosed late because of the lack pathognomonic symptoms. This study evaluated outcomes following liver resection (LR) for patients with HCC presenting large tumor size (over 10 cm), adjacent organ invasion, or ruptured tumor, which we termed as complicated (cHCC). Materials and Methods We retrospectively reviewed 660 who underwent LR between January 2001 July 2005. The were grouped into cHCC non‐cHCC according to defined criteria....

Idiopathic pulmonary fibrosis is a devastating disease with multiple contributing factors. Insulin-like growth factor 1 receptor (IGF1R), reciprocal function to aryl hydrocarbon (AhR), involved in airway inflammation. The exact relationship between IGF1R and AhR lung fibrogenesis unclear. This study aimed investigate the cascade pathway involving idiopathic fibrosis.The expressions were determined lungs of patients rodent model. Pulmonary was evaluated bleomycin (BLM)-induced injury wild...

Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin (NHL), accounting for approximately 25% all NHL cases. Primary appendiceal lymphomas (PAL) presenting as acute appendicitis are very rare, occurring in only 0.015% cases gastrointestinal lymphoma.A 57-year-old man who was initially presented and subsequently underwent interval laparoscopic appendectomy. Pathological examination revealed diffuse B cell with cut end involvement. Whole-body positron...

Myeloid differentiation-2 (MD-2) has been associated with endotoxin and inflammatory disorders because it can recognize lipopolysaccharide (LPS) binding attenuate Toll-like receptor 4 (TLR4)-mediated signaling. However, its role in allergic inflammation yet to be clarified. We examined whether single nucleotide polymorphisms (SNPs) MD-2 promoter affect expression aimed clarify the relationship between Der p 2 allergy SNPs of promoter.The function effects cytokines immunoglobulin on secretion...

To define the benefits of different methods for diagnosis pediatric appendicitis in Taiwan, a nationwide cohort study was used analysis. We identified 44,529 patients under 18 years old who had been hospitalized with acute between 2003 and 2012. analyzed percentages cases which ultrasound (US) and/or computed tomography (CT) were performed non-perforated perforated diagnosed each year. Multivariate logistic regression analyses to evaluate risk factors appendicitis. There more (N = 32,491)...

Abstract Background This study aimed to reevaluate the learning curve of laparoscopic Roux-en Y gastric bypass (LRYGB) in modern era while considering a single surgeon’s experience. Methods From beginning our LRYGB practice, all patients who met regional criteria and underwent primary were retrospectively enrolled. Patients with body mass index (BMI) > 50 kg/m 2 excluded. Those surgery 2016–17, 2018 2019 by surgeon 10 + years experience assigned groups A, B C, respectively. The patient...

The comprehensive coverage offered by the Taiwan National Health Insurance program enabled us to effectively evaluate effect of age on postoperative morbidity. To investigate whether affected outcomes and management appendicitis in children Taiwan. We use Collaboration Center for Information Application database identify 21,827 patients ≤18 years with a diagnosis acute between 2007 2012 Study included morbidity, undergoing laparoscopic appendectomy (LA) or open (OA), length hospitalization....

Diabetic retinopathy (DR) is a pathophysiologic vasculopathic process with obscure mechanisms and limited effective therapeutic strategies. Aryl hydrocarbon receptor (AhR) an important regulator of xenobiotic metabolism environmental sensor. The aim the present study was to investigate role AhR in development DR elucidate molecular mechanism its downregulation. evaluated diabetes-induced retinal injury wild type knockout (AhR-/-) mice. Retinal expression determined human donor mice eyes by...

Diabetic retinopathy, one of retinal vasculopathy, is characterized by inflammation, vascular leakage, blood-retinal barrier breakdown, and neovascularization. However, the molecular mechanisms that contribute to diabetic retinopathy progression remain unclear. Approach Results: Tpl2 (tumor locus 2) a protein kinase implicated in inflammation pathological angiogenesis. N

Background and Objective:Earlier exposure to laparoscopic techniques is thought be beneficial for medical students. Reports have demonstrated that practice improves performance in laparoscopies. In this study, we intended evaluate whether students' interest surgery affected by the amount of on a simulator.Methods:A simulation curriculum was introduced at Taipei Medical University, Wan-Fang Center. Study participants included 36 sixth-year 14 seventh-year students who were divided according...

Abstract Background and purpose: Histone deacetylase (HDAC) inhibitors (HDIs) were shown to modulate the epithelial-mesenchymal transition ( EMT ) progression inhibit migration invasion of cancer cells. Emerging as a novel class anti-cancer drugs, HDIs have attracted much attention in field drug discovery. This study aimed underlying mechanisms Honokiol preventing metastatic dissemination gastric cells by inhibiting HDAC3 activity/expression. Experimental Approach: Clinical pathological...

Acute abdominal pain during pregnancy is challenging, both from a diagnostic and management perspective. A non-localized, persistent out of proportion to physical examination sign that advanced imaging may be necessary. Mesenteric venous thrombosis in pregnant patient extremely rare, but if diagnosis delayed, can potentially fatal the mother fetus. We present here tenth week gestation with classic clinical manifestations mesenteric vein corresponding findings on magnetic resonance (MRI)...

Abstract Background The study aim was to reevaluate the learning curve of laparoscopic Roux-en Y gastric bypass (LRYGB) in modern era considering a single surgeon’s experience. Methods Except those with body mass index (BMI) >50 kg/m 2 needs further discussion; all other patients who met regional criteria and underwent primary LRYGB were retrospectively enrolled. Those surgery 2016-17, 2018 2019 by surgeon 10+ years experience assigned groups A, B C, respectively. Patient demographics...

Abstract Bleeding is a major and potentially life-threatening complication of peptic ulcer. Despite endoscopic hemostatic therapy advance, conventional modalities remain refractory for ulcer bleeding with big size, fibrous base or in difficult-to-access anatomical locations. In this study, we attempted to evaluate the efficacy safety cyanoacrylate injection treatment (ECIT) high-risk by therapy. The patients were carried out ECIT. data retrospectively collected. A total 119 accepted 74...