A5032279302- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Chemistry and Chemical Engineering
- Asymmetric Synthesis and Catalysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Oxidative Organic Chemistry Reactions
- Organic Chemistry Cycloaddition Reactions
- Click Chemistry and Applications
- Synthesis and Reactions of Organic Compounds
- Coordination Chemistry and Organometallics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fluorine in Organic Chemistry
- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- Conducting polymers and applications
- Crystallography and molecular interactions
- Molecular spectroscopy and chirality
Institute of Organic Synthesis
2013-2021
Ural Branch of the Russian Academy of Sciences
2018-2021
Russian Academy of Sciences
2014
The effect of the electronic nature para substituent on aromatic ring 2‐aryloxypropionyl chlorides stereochemical outcome acylation 3,4‐dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazine and its 7,8‐difluoro‐containing analogue has been studied. geometries diastereoisomeric transition states corresponding Gibbs free enthalpies activation were determined through DFT calculations at COSMO‐CH 2 Cl ‐B3LYP‐D3‐gCP/def2‐TZVP (or def2‐SVP)//B3LYP‐D3‐gCP/def2‐SVP level theory. It found that a low‐cost quantum...
Recent publications on the key preparation methods of enantiomers 2-aryloxy carboxylic acids are summarized and comparative analysis is given. The information arranged according to type starting compound, being classified into syntheses from enantiomerically pure chiral precursors prochiral precursors, which imply generation an asymmetric centre in substrate molecule. Data chemical resolution racemic mixtures title compounds addressed a separate Section. Attention focused practically...
Abstract Stereoselectivity in the mutual kinetic resolution (KR) of racemic 3,4‐dihydro‐3‐methyl‐2 H ‐[1,4]benzoxazines and 2‐aryloxy propionyl chlorides was studied. Based on results obtained, preparative methods for single enantiomers a series propionic acids via acylative KR their racemates with enantiopure ( S )‐3,4‐dihydro‐3‐methyl‐2 have been proposed.
The diastereoselective acylation of a number racemic methyl-substituted cyclic alkylamines with active esters 2-phenoxypropanoic acid was studied in detail. ester (R)-2-phenoxypropanoic and N-hydroxysuccinimide found to be the most selective agent. highest stereoselectivity observed kinetic resolution 2-methylpiperidine toluene at -40 °C (selectivity factor s = 73) predominant formation (R,R)-amide (93.7% de). To explain stereoselectivity, DFT modelling transition states reactions title...