A5024658667- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Orthopaedic implants and arthroplasty
- Coffee research and impacts
- Hepatitis C virus research
- Hip disorders and treatments
- Liver Disease and Transplantation
- Pelvic and Acetabular Injuries
- Tea Polyphenols and Effects
- Genetic Associations and Epidemiology
- Food Chemistry and Fat Analysis
- Orthopedic Infections and Treatments
- Genomics and Rare Diseases
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Atrial Fibrillation Management and Outcomes
- Elbow and Forearm Trauma Treatment
- Vagus Nerve Stimulation Research
- Telomeres, Telomerase, and Senescence
- Influenza Virus Research Studies
- Alzheimer's disease research and treatments
- Congenital gastrointestinal and neural anomalies
- Galectins and Cancer Biology
- Genomic variations and chromosomal abnormalities
- Bone Tissue Engineering Materials
Jilin University
2019-2025
University of Hong Kong
2022-2025
Hebei Academy of Agriculture and Forestry Sciences
2025
Boston University
2020-2025
Yunnan Institute of Tropical Crops
2021-2024
Kunming University of Science and Technology
2024
Southern Medical University
2023-2024
Nanfang Hospital
2024
Guangxi University
2021-2024
Kunming Institute of Botany
2021-2024
α-Klotho is a potential biological marker of aging with satisfactory clinical applicability. However, its prognostic significance in age-related diseases has largely been undermined. Therefore, we aimed to report the value serum α-klotho levels diseases.
BackgroundPrior studies examined variants within presenilin-2 (PSEN2), presenilin-1 (PSEN1), and amyloid precursor protein (APP) genes. However, previously-reported clinically-relevant other predicted damaging missense (DM) have not been characterized in a newer release of the Alzheimer's Disease Sequencing Project (ADSP).ObjectiveTo characterize DM PSEN2, PSEN1, APP participants from ADSP.MethodsWe identified rare (MAF < 1%) 14,641 individuals with whole genome sequencing 16,849 exome...
This study attempted to improve commercial Arabica coffee quality by integrating flavor precursors with anaerobic germination. Using raw beans as materials, germination was conducted 5 g/100 g of (sucrose, glucose, fructose). The chemical composition and sensory roasted were analyzed. Results showed that adding facilitated the harmonization water-soluble components altered aroma characteristics. Specifically, inclusion significantly increased levels 5-Hydroxymethylfurfural volatile...
Bone nonunion has become one of the most severe sequelae fractures, infections, bone tumors, or revision arthroplasty owing to its high morbidity and disability rate. Recently, received considerable attention from plastic surgeons. There are different treatment methods for depending on classification according etiology pathological types. tissue engineering provides advanced platforms via use material scaffolds with sufficient mechanical strength. Meanwhile, it promotes regeneration...
BACKGROUND:Ropivacaine is commonly used as an intercostal nerve block, but its effects on postoperative cognitive dysfunction (POCD) have not previously been investigated. This study aimed to examine the of use ropivacaine block early POCD, analgesia, and inflammation in patients following thoracotomy for esophageal cancer. MATERIAL AND METHODS:One hundred with cancer undergoing were randomly divided into a group (group A) (n=50) control B) (n=50). The function score visual analog scale...
Objective: We aimed to investigate whether a novel noninvasive index, i.e., the international normalized ratio-to-platelet ratio (INPR), was variable in determining liver fibrosis stage patients with chronic hepatitis B (CHB). Methods: A total of 543 treatment-naïve CHB were retrospectively enrolled. Liver histology assessed according Metavir scoring scheme. All common demographic and clinical parameters analyzed. Results: Based on routine (age, sex, HBeAg status, HBV DNA, hematological...
This study aimed to improve the brewing quality of commercial Arabica coffee through anaerobic germination. Changes in important compounds and cupping scores germination roasting with different degrees were investigated by 1H NMR, HS-SPME-GC-MS sensory analysis. Statistical analysis multivariate results indicated that 6 water-soluble chemical components 8 volatile have potential be markers germinated coffee. In addition, significantly reduced caffeine content acrylamide formation roasted...
Background: It had been shown that selective cardiac vagal activation holds great potential for heart regeneration.Optogenetics has clinical translation as a novel means of modulating targeted neurons.This study aimed to investigate whether via optogenetics could improve regenerative repair after myocardial infarction (MI) and identify the underlying mechanism.Methods: We used an adeno-associated virus (AAV) vector deliver ChR2, light-sensitive protein, left nodose ganglion (LNG).To assess...
Treatment of large bone defects resulting from acute injury or infection remains challenging. The Masquelet technique is a two-stage procedure for treating caused by tumor resection, infection, trauma. There are currently no reports successful repair ≥28 cm using the technique. We describe case 55-year-old man with postoperative femoral fracture and 28-cm infected defect formed after multiple debridement procedures. technique, when coupled Lantern-Mimicking Frame System (LMFS), achieved...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disorder and lacks effective treatments because of unclear mechanisms. Aberrant function alveolar macrophages directly linked to fibrosis. Here, we show TIM-3 (T-cell immunoglobulin domain mucin domain-3), key regulator macrophage function, aggravates mRNA patients with IPF was analyzed based on the Gene Expression Omnibus Array Express databases. Lung pathology profibrotic molecules were assessed in bleomycin (BLM)-induced...
Introduction Winter wheat is a crucial crop extensively cultivated in northern China, where its grain yield influenced by genetic factors (G), environmental conditions (E), and their interactions (GEI). Accurate estimation depends on understanding the patterns of GEI multi-environment trials (METs). Methods From 2014 to 2018, continuous experiments were conducted Heilonggang region North China Plain (NCP), evaluating 71 winter genotypes across 16 locations over five years. Leveraging 30...
This study aimed to investigate the effects of maturity on changes in major lipid metabolites coffee and their associated pathways. UPLC-ESI-MS/MS was used compare lipidomic profiles beans at five different stages. A total 516 across 26 subclasses were identified, with 111 showing significant differences. Glycerolipids (GL) fatty acyls (FA) most abundant, followed by glycerophospholipids (GP), sphingolipids (SP) prenol lipids (PR). PCA OPLS-DA analyses demonstrated during maturation....
Objective: This study aimed to identify the predictive value of simple markers in routine blood and coagulation tests for severity coronavirus disease 2019 (COVID-19).Methods: A total 311 consecutive COVID-19 patients, including 281 patients with mild/moderate 30 severe/life-threatening COVID-19, were retrospectively enrolled.Logistic modeling ROC curve analyses used assess indexes identifying severity.Results: Lymphocyte eosinophil counts group significantly lower than those (P <...
Abstract A novel strain of influenza A(H7N9) virus has emerged in China and is causing mild to severe clinical symptoms infected humans. Some case-patients have died. To further knowledge this virus, we report the characteristics histories 4 early case-patients.
The current clinical practice on chronic hepatitis B (CHB) requires better on-treatment monitoring of viral persistence. Quantified assays for surface antigen (HBsAg) and core-related (HBcrAg) hold promise further optimization therapy. Here, we aimed to characterize HBcrAg during the natural course CHB.Four-hundred forty four treatment naïve CHB patients, who all underwent liver histology examination, were enrolled in this cross-sectional study. Their HBV DNA, HBsAg, HBeAg titres quantified...
Abstract Background We aimed to formulate a novel predictive nomogram discriminate liver fibrosis stage in patients with chronic disease. Methods Nomograms were established based on the results of multivariate analysis. The accuracy nomograms was assessed by ROC analysis and calibration. Decision curve (DCA) used determine clinical benefit nomograms. Results INR, platelets, N-terminal propeptide type III collagen (PIIINP) independent predictors for advanced (≥ S3) cirrhosis (S4) disease...
Clinical importance of commercially available quantitative HBV markers has not been fully investigated. To choice and to evaluate clinically valuable for predicting phases natural history with chronic infection. 472 naïve patients infection were enrolled, in which 21 220 confirmed as HBeAg-positive inactive active hepatitis (EPIH EPAH), respectively, 106 125 HBeAg-negative (ENIH ENAH), respectively. HBsAg, HBcrAg anti- HBc measured using chemiluminescent immunoassay, DNA was PCR-fluorescence...