A5091022615- Rheumatoid Arthritis Research and Therapies
- Orthopedic Surgery and Rehabilitation
- Musculoskeletal synovial abnormalities and treatments
- Elbow and Forearm Trauma Treatment
- Advanced Machining and Optimization Techniques
- Non-Destructive Testing Techniques
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Lower Extremity Biomechanics and Pathologies
- Viral Infections and Immunology Research
- Medical and Biological Sciences
- Hip and Femur Fractures
- Foot and Ankle Surgery
- Bone and Joint Diseases
- Advanced Surface Polishing Techniques
- Muscle activation and electromyography studies
- Diabetic Foot Ulcer Assessment and Management
- Total Knee Arthroplasty Outcomes
- Welding Techniques and Residual Stresses
- Cerebral Palsy and Movement Disorders
- Muscle Physiology and Disorders
- Spinal Cord Injury Research
- Cardiovascular Function and Risk Factors
- Inflammatory Myopathies and Dermatomyositis
- Prosthetics and Rehabilitation Robotics
Kyoto Prefectural University of Medicine
2016-2025
Institute for Rheumatic Diseases (Japan)
2024
University Hospital Kyoto Prefectural University of Medicine
2018-2020
Kogakuin University
2016-2020
Foundation for Physical Medicine and Rehabilitation
2017-2019
International University of Health and Welfare
2017-2019
Kishokai Medical Corporation
2017-2019
Kobe Central Hospital
2010-2011
Loma Linda University
1994
We investigated the effects of belt electrode-skeletal muscle electrical stimulation (B-SES) on atrophy in collagen-induced arthritis (CIA) rats. Twenty-eight 8-week-old male Dark Agouti rats were immunized with type II collagen and Freund's incomplete adjuvant (day 0). From days 14 to 28, 18 received B-SES (50 Hz) four times only right hindlimb (STIM), while contralateral left remained unstimulated. Both hindlimbs 10 untreated CIA defined as controls (CONT). Paw volume was measured every...
Treatments for rheumatoid arthritis (RA) have improved since methotrexate and biological agents were approved; however, few longitudinal analyses tracked joint destruction, deformity progression, or functional impairments that directly affect the activities of daily living. Due to consequences impairments, we conducted this study glean more information regarding progression over time.This enrolled 134 hands in 67 RA patients with hand deformities 2004. After 5 years, 100 52 eligible final...
Exercise therapy inhibits joint destruction by suppressing pro-inflammatory cytokines. The efficacy of pharmacotherapy for rheumatoid arthritis differs depending on the phase disease, but that exercise each is unknown. We assessed differences in treadmill running at various phases, using rat models. Rats with collagen-induced were used as models, and after immunization was divided pre-arthritis established phases. Histologically, groups forced had significantly inhibited compared other...
Spontaneous flexor tendon rupture is usually caused by trauma, systemic diseases, or carpal bone and joint disorders. Here we report a case of spontaneous occurring in lupus erythematosus (SLE) patient following nonunion the hamate hook after an insufficiency fracture, which was also associated with degeneration SLE. A 57-year-old woman diagnosed SLE 22 years ago being treated oral prednisolone. She became unable to flex her left little finger without any history trauma sporting activity. CT...
The effects of treadmill running under hypoxic conditions on joints and muscles collagen-induced arthritis (CIA) rats were investigated. CIA divided into normoxia no-exercise, hypoxia no-exercise (Hypo-no), exercise (Hypo-ex) groups. Changes examined days 2 44 with or without exercises. In the early stage hypoxia, expression hypoxia-inducible factor (HIF)-1α increased in Hypo-no Hypo-ex egl-9 family 1 (EGLN1) vascular endothelial growth (VEGF) group also increased. Under sustained groups did...
Foot impairment in rheumatoid arthritis (RA) may exacerbate sarcopenia from physical inactivity because of foot pain while walking. The present study aimed to investigate the prevalence patients with RA-associated impairment, and whether treatment a orthosis improved activity muscle quantity.Thirty-two RA were diagnosed as sarcopenic or nonsarcopenic, was determined. Eleven treated orthosis. following parameters compared between baseline after 6 months treatment: (walking, moderate-intensity...
Abstract Background Although drug therapy for rheumatoid arthritis (RA) has recently improved, treating patients with established disease, whose hands have three major deformities (thumb deformity, finger deformities, and ulnar drift), remains a challenge. The underlying complex pathophysiology makes understanding these difficult, comprehensive assessment methods require accumulated skill long learning curves. We aimed to establish simpler composite method understand the of alterations in...
The aim of this study was to examine the correlation between basic movement ability and activities daily living (ADL) in elderly patients after hip fracture surgery predict ADL outcomes from changes ability.Fifty-four receiving rehabilitation were collected prospectively. Ambulatory evaluated using a Basic Movement Scale (BMS), motor subscale Functional Independence Measure (motor-FIM). From results evaluating BMS motor-FIM weekly, important postoperative period regain investigated.There...
Objectives: To assess the effectiveness and safety of interferon-free direct-acting antiviral (DAA) therapy for patients with concomitant hepatitis C virus (HCV) infection rheumatic diseases (RDs), including rheumatoid arthritis (RA).Methods: This was a single-center observational case-series study conducted in Japan from 2014 to 2018. The primary endpoint sustained virological response (SVR) rate 24 weeks after end (EoT24). We also evaluated hepatological rheumatological outcomes adverse...
To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis (RA).We established an observational cohort of 67 patients (134 hands) beginning 2004. Fifty-two (100 had follow-up 2009 and 37 (63 completed 2015. UD was evaluated with the Fearnley classification our scoring method, which assesses four parameters metacarpophalangeal joint. Cluster analysis using divided hands into groups. Changes over time, correlation stage cluster functional assessment, reliability were...
The Sauvé–Kapandji (S–K) procedure is a common treatment for rheumatoid wrists, but in some cases severe bone destruction makes this operative modality difficult to perform, while also resulting poor outcome. A modified S–K these wrists has been reported, the clinical outcomes of are unclear. This study evaluated 24 20 patients who underwent procedure. mean follow-up period was 34.5 months. assessments were range motion, carpal translation and bony shelf size. motion similar those produced...
Ample evidence on etiological and pathological differences between femoral neck trochanteric fracture cases suggests the possibility of individualized treatment. There are many issues related to areal bone mineral density other quantitative computed tomography parameters proximal femur. Although osteoporosis is a systemic problem, little has been reported regarding in structural parameters, including density, them regions than femur.Participants were consecutive female patients >50 years age...
To examine the recurrence of deformity after silicone implant arthroplasty combined with resection for severe forefoot in patients rheumatoid arthritis.We reviewed long-term results this procedure 27 feet 15 patients. Their average age and disease duration at time operation were 58.6 years 17.5 years, respectively, follow-up period was 10.3 years.An improved hallux valgus angle (45.3° preoperatively, 23.6° 6 months operation) maintained. By contrast, dislocation lesser toe had recurred final...
The Sauvé-Kapandji (S-K) procedure is a common treatment for rheumatoid wrists, but in some cases severe bone destruction makes this operative modality difficult to perform, while also resulting poor outcome. A modified S-K these wrists has been reported, the clinical outcomes of are unclear. This study evaluated 24 20 patients who underwent procedure. mean follow-up period was 34.5 months. assessments were range motion, carpal translation and bony shelf size. motion similar those produced...
Objective: Nalebuff’s type I deformity of the rheumatoid thumb, which is most common thumb with arthritis, can be classified into three stages according to range motion thumb. However, a functional assessment for each stage has never been undertaken. Methods: The ranges metacarpophalangeal and interphalangeal joints were evaluated determine clinical stage, both Modified Kapandji Index (MKI) simple test evaluating hand function (STEF) used evaluate in 32 arthritis patients deformity. We...
ABSTRACT Patients with established rheumatoid arthritis (RA) are at risk of developing secondary sarcopenia. Both pharmacological and exercise interventions essential for treatment. However, such patients, loads may lead to the progression joint destruction worsening pain. The purpose this report was assess feasibility a home-based, low-intensity resistance programme. case 70-year-old female patient sarcopenia RA. She diagnosed RA 57 years age began medication, maintaining remission disease...
Abstract Background Even with pharmacotherapy according to current treatment guidelines, the remaining 3–8% of patients difficult-to-treat rheumatoid arthritis (D2T RA) do not achieve goals. While it is important accumulate further evidence on pharmacotherapy, also essential non-pharmacological therapies as potential alternatives. This study aims investigate therapeutic effect orthopedic surgical intervention (OSI) in D2T RA a modality by comparing non-D2T RA. Methods A total 534 recent...
To elucidate the therapeutic effect of orthopedic surgical intervention (OSI) in difficult-to-treat rheumatoid arthritis (D2T RA) compared with non-D2T RA.